Caveolin-1 stabilizes ATP7A, a copper transporter for extracellular SOD, in vascular tissue to maintain endothelial function.

Animals Aorta / cytology Caveolin 1 / deficiency Copper / pharmacology Copper Transport Proteins / genetics Copper-Transporting ATPases / genetics Endothelial Cells / cytology Fibroblasts / cytology Gene Expression Regulation Male Mesenteric Arteries / cytology Mice Mice, Inbred C57BL Mice, Knockout Molecular Chaperones / genetics Oxidative Stress Primary Cell Culture Proteasome Endopeptidase Complex / metabolism Proteolysis Signal Transduction Superoxide Dismutase / genetics Superoxide Dismutase-1 / genetics Ubiquitination / drug effects Vasodilation / drug effects
ATP7A SOD3 caveolin-1 endothelial function oxidative stress

Journal

American journal of physiology. Cell physiology
ISSN: 1522-1563
Titre abrégé: Am J Physiol Cell Physiol
Pays: United States
ID NLM: 100901225

Informations de publication

Date de publication:
01 11 2020
Historique:
pubmed: 17 9 2020
medline: 17 12 2020
entrez: 16 9 2020
Statut: ppublish

Résumé

Caveolin-1 (Cav-1) is a scaffolding protein and a major component of caveolae/lipid rafts. Previous reports have shown that endothelial dysfunction in Cav-1-deficient (Cav-1

Identifiants

DOI: 10.1152/ajpcell.00151.2020 PMID: 32936699 PMC: PMC7789967
pubmed: 32936699
doi: 10.1152/ajpcell.00151.2020
pmc: PMC7789967
doi:

Substances chimiques

Atox1 protein, mouse 0
Atp7a protein, mouse 0
Cav1 protein, mouse 0
Caveolin 1 0
Copper Transport Proteins 0
Molecular Chaperones 0
Copper 789U1901C5
Sod1 protein, mouse EC 1.15.1.1
Sod3 protein, mouse EC 1.15.1.1
Superoxide Dismutase EC 1.15.1.1
Superoxide Dismutase-1 EC 1.15.1.1
Proteasome Endopeptidase Complex EC 3.4.25.1
Copper-Transporting ATPases EC 7.2.2.8
cupric chloride S2QG84156O

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

C933-C944

Subventions

Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)
ID : R01HL116976
Pays : International
Organisme : NHLBI NIH HHS
ID : R01 HL135584
Pays : United States
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)
ID : R01HL133613
Pays : International
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)
ID : R21HL112293
Pays : International
Organisme : NHLBI NIH HHS
ID : R01 HL147550
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM130457
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142636
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL083298
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133613
Pays : United States
Organisme : BLRD VA
ID : I01 BX001232
Pays : United States
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)
ID : R01HL077524-S1
Pays : International
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)
ID : R01HL077524
Pays : International
Organisme : NHLBI NIH HHS
ID : R01 HL125356
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070187
Pays : United States

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Auteurs

Varadarajan Sudhahar (V)

Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia.
Department of Pharmacology and Toxicology, Medical College of Georgia at Augusta University, Augusta, Georgia.
Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia.

Mustafa Nazir Okur (MN)

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.

John P O'Bryan (JP)

Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina.

Richard D Minshall (RD)

Departments of Anesthesiology and Pharmacology, University of Illinois at Chicago, Chicago, Illinois.

David Fulton (D)

Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia.
Department of Pharmacology and Toxicology, Medical College of Georgia at Augusta University, Augusta, Georgia.

Masuko Ushio-Fukai (M)

Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia.
Department of Medicine (Cardiology), Medical College of Georgia at Augusta University, Augusta, Georgia.

Tohru Fukai (T)

Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia.
Department of Pharmacology and Toxicology, Medical College of Georgia at Augusta University, Augusta, Georgia.
Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Aorte › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Cavéoline-1 › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Cuivre › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs de cations › Protéines de transport du cuivre › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › P-type ATPases › Copper-transporting ATPases › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Artères mésentériques › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Chaperons moléculaires › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture cellulaire › Culture de cellules primaires › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Proteasome endopeptidase complex › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Métabolisme › Protéolyse › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Superoxide dismutase › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Superoxide dismutase › Superoxide dismutase-1 › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Ubiquitination › Caveolin-1 stabilizes ATP7A, a copper...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Vasodilatation › Caveolin-1 stabilizes ATP7A, a copper...