Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy.
Adolescent
Adult
Anti-Retroviral Agents
/ therapeutic use
Child
Child, Preschool
Chronic Disease
HIV Infections
/ blood
Humans
Immunity, Innate
Infant
Infant, Newborn
Killer Cells, Natural
/ immunology
Lymphocyte Activation
/ immunology
Lymphocyte Depletion
Lymphocyte Subsets
/ immunology
Lymphocytes
/ immunology
Palatine Tonsil
/ immunology
Transcription, Genetic
Young Adult
HIV
ILCs
NK cells
pediatric infection
tonsil
vertical transmission
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
15 09 2020
15 09 2020
Historique:
received:
05
08
2019
revised:
14
03
2020
accepted:
25
08
2020
entrez:
16
9
2020
pubmed:
17
9
2020
medline:
5
5
2021
Statut:
ppublish
Résumé
Innate lymphoid cells (ILCs) are important for response to infection and for immune development in early life. HIV infection in adults depletes circulating ILCs, but the impact on children infected from birth remains unknown. We study vertically HIV-infected children from birth to adulthood and find severe and persistent depletion of all circulating ILCs that, unlike CD4
Identifiants
pubmed: 32937142
pii: S2211-1247(20)31142-6
doi: 10.1016/j.celrep.2020.108153
pmc: PMC7495043
pii:
doi:
Substances chimiques
Anti-Retroviral Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108153Subventions
Organisme : NIAID NIH HHS
ID : R01 AI133673
Pays : United States
Organisme : Wellcome Trust
ID : 210662/Z/18/Z
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : U24 AI118672
Pays : United States
Organisme : Wellcome Trust
ID : 107752/Z/15/Z
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL134539
Pays : United States
Organisme : Wellcome Trust
ID : WT104748MA
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : U19 AI089992
Pays : United States
Organisme : Wellcome Trust
ID : 202485/Z/16/Z
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI138546
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL095791
Pays : United States
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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