Systemic Immunometabolism: Challenges and Opportunities.
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
15 09 2020
15 09 2020
Historique:
received:
27
05
2020
revised:
13
08
2020
accepted:
21
08
2020
entrez:
16
9
2020
pubmed:
17
9
2020
medline:
23
4
2021
Statut:
ppublish
Résumé
Over the past 10 years, the field of immunometabolism made great strides to unveil the crucial role of intracellular metabolism in regulating immune cell function. Emerging insights into how systemic inflammation and metabolism influence each other provide a critical additional dimension on the organismal level. Here, we discuss the concept of systemic immunometabolism and review the current understanding of the communication circuits that underlie the reciprocal impact of systemic inflammation and metabolism across organs in inflammatory and infectious diseases, as well as how these mechanisms apply to homeostasis. We present current challenges of systemic immunometabolic research, and in this context, highlight opportunities and put forward ideas to effectively explore organismal physiological complexity in both health and disease.
Identifiants
pubmed: 32937151
pii: S1074-7613(20)30369-1
doi: 10.1016/j.immuni.2020.08.012
pmc: PMC7491485
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
496-509Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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