Alexander Lercher

Affiliations

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

Publications (19)

SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8

Science immunology

Avec: Benedikt Agerer , Maximilian Koblischke , Venugopal Gudipati , Luis Fernando Montaño-Gutierrez , Mark Smyth , Alexandra Popa , Jakob-Wendelin Genger , Lukas Endler , David M Florian , Vanessa Mühlgrabner , Marianne Graninger , Stephan W Aberle , Anna-Maria Husa , Lisa Ellen Shaw , Alexander Lercher , Pia Gattinger , Ricard Torralba-Gombau , Doris Trapin , Thomas Penz , Daniele Barreca , Ingrid Fae , Sabine Wenda , Marianna Traugott , Gernot Walder , Winfried F Pickl , Volker Thiel , Franz Allerberger , Hannes Stockinger , Elisabeth Puchhammer-Stöckl , Wolfgang Weninger , Gottfried Fischer , Wolfgang Hoepler , Erich Pawelka , Alexander Zoufaly , Rudolf Valenta , Christoph Bock , Wolfgang Paster , René Geyeregger , Matthias Farlik , Florian Halbritter , Johannes B Huppa , Judith H Aberle , Andreas Bergthaler

Environmental arginine controls multinuclear giant cell metabolism and formation.

Nature communications

Avec: Julia S Brunner , Loan Vulliard , Melanie Hofmann , Markus Kieler , Alexander Lercher , Andrea Vogel , Marion Russier , Johanna B Brüggenthies , Martina Kerndl , Victoria Saferding , Birgit Niederreiter , Alexandra Junza , Annika Frauenstein , Carina Scholtysek , Yohei Mikami , Kristaps Klavins , Gerhard Krönke , Andreas Bergthaler , John J O'Shea , Thomas Weichhart , Felix Meissner , Josef S Smolen , Paul Cheng , Oscar Yanes , Jörg Menche , Peter J Murray , Omar Sharif , Stephan Blüml , Gernot Schabbauer

The versatility of external quality assessment for the surveillance of laboratory and

Clinical chemistry and laboratory medicine

Avec: Christoph Buchta , Jeremy V Camp , Jovana Jovanovic , Peter Chiba , Elisabeth Puchhammer-Stöckl , Maximilian Mayerhofer , Helga Plicka , Alexander Lercher , Alexandra M Popa , Lukas Endler , Andreas Bergthaler , Wolfgang Huf , Bernhard Benka , Vincent Delatour , Mathias M Müller , Andrea Griesmacher , Stephan W Aberle , Irene Görzer

Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function.

Immunity

Avec: Alexander Lercher , Anannya Bhattacharya , Alexandra M Popa , Michael Caldera , Moritz F Schlapansky , Hatoon Baazim , Benedikt Agerer , Bettina Gürtl , Lindsay Kosack , Peter Májek , Julia S Brunner , Dijana Vitko , Theresa Pinter , Jakob-Wendelin Genger , Anna Orlova , Natalia Pikor , Daniela Reil , Maria Ozsvár-Kozma , Ulrich Kalinke , Burkhard Ludewig , Richard Moriggl , Keiryn L Bennett , Jörg Menche , Paul N Cheng , Gernot Schabbauer , Michael Trauner , Kristaps Klavins , Andreas Bergthaler

AIF-regulated oxidative phosphorylation supports lung cancer development.

Cell research

Avec: Shuan Rao , Laura Mondragón , Blanka Pranjic , Toshikatsu Hanada , Gautier Stoll , Thomas Köcher , Peng Zhang , Alexander Jais , Alexander Lercher , Andreas Bergthaler , Daniel Schramek , Katharina Haigh , Valentina Sica , Marion Leduc , Nazanine Modjtahedi , Tsung-Pin Pai , Masahiro Onji , Iris Uribesalgo , Reiko Hanada , Ivona Kozieradzki , Rubina Koglgruber , Shane J Cronin , Zhigang She , Franz Quehenberger , Helmut Popper , Lukas Kenner , Jody J Haigh , Oliver Kepp , Malgorzata Rak , Kaican Cai , Guido Kroemer , Josef M Penninger

The serine's call: Suppressing interferon responses.

Cell metabolism

Avec: Benedikt Agerer , Alexander Lercher , Andreas Bergthaler

Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection.

bioRxiv : the preprint server for biology

Avec: Alexander Lercher , Jin-Gyu Cheong , Chenyang Jiang , Hans-Heinrich Hoffmann , Alison W Ashbrook , Yue S Yin , Corrine Quirk , Emma J DeGrace , Luis Chiriboga , Brad R Rosenberg , Steven Z Josefowicz , Charles M Rice

CD8

Nature immunology

Avec: Hatoon Baazim , Martina Schweiger , Michael Moschinger , Haifeng Xu , Thomas Scherer , Alexandra Popa , Suchira Gallage , Adnan Ali , Kseniya Khamina , Lindsay Kosack , Bojan Vilagos , Mark Smyth , Alexander Lercher , Joachim Friske , Doron Merkler , Alan Aderem , Thomas H Helbich , Mathias Heikenwälder , Philipp A Lang , Rudolf Zechner , Andreas Bergthaler

Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis.

PLoS pathogens

Avec: Alexander Lercher , Alexandra M Popa , Csilla Viczenczova , Lindsay Kosack , Kristaps Klavins , Benedikt Agerer , Christiane A Opitz , Tobias V Lanz , Michael Platten , Andreas Bergthaler

Characterization of CD8 T Cell-Mediated Mutations in the Immunodominant Epitope GP33-41 of Lymphocytic Choriomeningitis Virus.

Frontiers in immunology

Avec: Mark Smyth , Kseniya Khamina , Alexandra Popa , Venugopal Gudipati , Benedikt Agerer , Alexander Lercher , Lindsay Kosack , Lukas Endler , Hatoon Baazim , Csilla Viczenczova , Johannes B Huppa , Andreas Bergthaler

24-Norursodeoxycholic acid reshapes immunometabolism in CD8

Journal of hepatology

Avec: Ci Zhu , Nicole Boucheron , André C Müller , Peter Májek , Thierry Claudel , Emina Halilbasic , Hatoon Baazim , Alexander Lercher , Csilla Viczenczova , Daniela Hainberger , Teresa Preglej , Lisa Sandner , Marlis Alteneder , Alexandra F Gülich , Matarr Khan , Patricia Hamminger , Jelena Remetic , Anna Ohradanova-Repic , Philipp Schatzlmaier , Clemens Donner , Claudia D Fuchs , Tatjana Stojakovic , Hubert Scharnagl , Shinya Sakaguchi , Thomas Weichhart , Andreas Bergthaler , Hannes Stockinger , Wilfried Ellmeier , Michael Trauner

Heteromultimeric sarbecovirus receptor binding domain immunogens primarily generate variant-specific neutralizing antibodies.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Trinity Zang , Edmund Osei Kuffour , Viren A Baharani , Marie Canis , Fabian Schmidt , Justin Da Silva , Alexander Lercher , Pooja Chaudhary , Hans-Heinrich Hoffmann , Anna Gazumyan , Ileana C Miranda , Margaret R MacDonald , Charles M Rice , Michel C Nussenzweig , Theodora Hatziioannou , Paul D Bieniasz

Epigenetic memory of coronavirus infection in innate immune cells and their progenitors.

Cell

Avec: Jin-Gyu Cheong , Arjun Ravishankar , Siddhartha Sharma , Christopher N Parkhurst , Simon A Grassmann , Claire K Wingert , Paoline Laurent , Sai Ma , Lucinda Paddock , Isabella C Miranda , Emin Onur Karakaslar , Djamel Nehar-Belaid , Asa Thibodeau , Michael J Bale , Vinay K Kartha , Jim K Yee , Minh Y Mays , Chenyang Jiang , Andrew W Daman , Alexia Martinez de Paz , Dughan Ahimovic , Victor Ramos , Alexander Lercher , Erik Nielsen , Sergio Alvarez-Mulett , Ling Zheng , Andrew Earl , Alisha Yallowitz , Lexi Robbins , Elyse LaFond , Karissa L Weidman , Sabrina Racine-Brzostek , He S Yang , David R Price , Louise Leyre , André F Rendeiro , Hiranmayi Ravichandran , Junbum Kim , Alain C Borczuk , Charles M Rice , R Brad Jones , Edward J Schenck , Robert J Kaner , Amy Chadburn , Zhen Zhao , Virginia Pascual , Olivier Elemento , Robert E Schwartz , Jason D Buenrostro , Rachel E Niec , Franck J Barrat , Lindsay Lief , Joseph C Sun , Duygu Ucar , Steven Z Josefowicz

Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection ameliorates secondary influenza A virus disease.

Immunity

Avec: Alexander Lercher , Jin-Gyu Cheong , Michael J Bale , Chenyang Jiang , Hans-Heinrich Hoffmann , Alison W Ashbrook , Tyler Lewy , Yue S Yin , Corrine Quirk , Emma J DeGrace , Luis Chiriboga , Brad R Rosenberg , Steven Z Josefowicz , Charles M Rice

Structural cells are key regulators of organ-specific immune responses.

Nature

Avec: Thomas Krausgruber , Nikolaus Fortelny , Victoria Fife-Gernedl , Martin Senekowitsch , Linda C Schuster , Alexander Lercher , Amelie Nemc , Christian Schmidl , André F Rendeiro , Andreas Bergthaler , Christoph Bock

The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages.

Nature metabolism

Avec: Julia S Brunner , Andrea Vogel , Alexander Lercher , Michael Caldera , Ana Korosec , Marlene Pühringer , Melanie Hofmann , Alexander Hajto , Markus Kieler , Lucia Quemada Garrido , Martina Kerndl , Mario Kuttke , Ildiko Mesteri , Maria W Górna , Marta Kulik , Paulina M Dominiak , Amanda E Brandon , Emma Estevez , Casey L Egan , Florian Gruber , Martina Schweiger , Jörg Menche , Andreas Bergthaler , Thomas Weichhart , Kristaps Klavins , Mark A Febbraio , Omar Sharif , Gernot Schabbauer

Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2.

Science translational medicine

Avec: Alexandra Popa , Jakob-Wendelin Genger , Michael D Nicholson , Thomas Penz , Daniela Schmid , Stephan W Aberle , Benedikt Agerer , Alexander Lercher , Lukas Endler , Henrique Colaço , Mark Smyth , Michael Schuster , Miguel L Grau , Francisco Martínez-Jiménez , Oriol Pich , Wegene Borena , Erich Pawelka , Zsofia Keszei , Martin Senekowitsch , Jan Laine , Judith H Aberle , Monika Redlberger-Fritz , Mario Karolyi , Alexander Zoufaly , Sabine Maritschnik , Martin Borkovec , Peter Hufnagl , Manfred Nairz , Günter Weiss , Michael T Wolfinger , Dorothee von Laer , Giulio Superti-Furga , Nuria Lopez-Bigas , Elisabeth Puchhammer-Stöckl , Franz Allerberger , Franziska Michor , Christoph Bock , Andreas Bergthaler

Systemic Immunometabolism: Challenges and Opportunities.

Immunity

Avec: Alexander Lercher , Hatoon Baazim , Andreas Bergthaler

Listeria monocytogenes infection rewires host metabolism with regulatory input from type I interferons.

PLoS pathogens

Avec: Duygu Demiroz , Ekaterini Platanitis , Michael Bryant , Philipp Fischer , Michaela Prchal-Murphy , Alexander Lercher , Caroline Lassnig , Manuela Baccarini , Mathias Müller , Andreas Bergthaler , Veronika Sexl , Marlies Dolezal , Thomas Decker

Réseau de co-auteurs

Andreas Bergthaler 15 collaborations

Benedikt Agerer 6 collaborations

Hatoon Baazim 5 collaborations

Mark Smyth 4 collaborations

Alexandra Popa 4 collaborations

Lukas Endler 4 collaborations

Kristaps Klavins 4 collaborations

Lindsay Kosack 4 collaborations

Charles M Rice 4 collaborations

Jakob-Wendelin Genger 3 collaborations

Stephan W Aberle 3 collaborations

Elisabeth Puchhammer-Stöckl 3 collaborations

Christoph Bock 3 collaborations

Julia S Brunner 3 collaborations

Thomas Weichhart 3 collaborations

Jörg Menche 3 collaborations

Gernot Schabbauer 3 collaborations

Alexandra M Popa 3 collaborations

Jin-Gyu Cheong 3 collaborations

Chenyang Jiang 3 collaborations

Hans-Heinrich Hoffmann 3 collaborations

Steven Z Josefowicz 3 collaborations

Csilla Viczenczova 3 collaborations

Venugopal Gudipati 2 collaborations

Thomas Penz 2 collaborations

Franz Allerberger 2 collaborations

Hannes Stockinger 2 collaborations

Erich Pawelka 2 collaborations

Alexander Zoufaly 2 collaborations

Johannes B Huppa 2 collaborations

Judith H Aberle 2 collaborations

Melanie Hofmann 2 collaborations

Markus Kieler 2 collaborations

Andrea Vogel 2 collaborations

Martina Kerndl 2 collaborations

Omar Sharif 2 collaborations

Michael Caldera 2 collaborations

Peter Májek 2 collaborations

Michael Trauner 2 collaborations

Alison W Ashbrook 2 collaborations

Yue S Yin 2 collaborations

Corrine Quirk 2 collaborations

Emma J DeGrace 2 collaborations

Luis Chiriboga 2 collaborations

Brad R Rosenberg 2 collaborations

Martina Schweiger 2 collaborations

Kseniya Khamina 2 collaborations

Michael J Bale 2 collaborations

André F Rendeiro 2 collaborations

Martin Senekowitsch 2 collaborations

Maximilian Koblischke 1 collaboration

Luis Fernando Montaño-Gutierrez 1 collaboration

David M Florian 1 collaboration

Vanessa Mühlgrabner 1 collaboration

Marianne Graninger 1 collaboration

Anna-Maria Husa 1 collaboration

Lisa Ellen Shaw 1 collaboration

Pia Gattinger 1 collaboration

Ricard Torralba-Gombau 1 collaboration

Doris Trapin 1 collaboration

Daniele Barreca 1 collaboration

Ingrid Fae 1 collaboration

Sabine Wenda 1 collaboration

Marianna Traugott 1 collaboration

Gernot Walder 1 collaboration

Winfried F Pickl 1 collaboration

Volker Thiel 1 collaboration

Wolfgang Weninger 1 collaboration

Gottfried Fischer 1 collaboration

Wolfgang Hoepler 1 collaboration

Rudolf Valenta 1 collaboration

Wolfgang Paster 1 collaboration

René Geyeregger 1 collaboration

Matthias Farlik 1 collaboration

Florian Halbritter 1 collaboration

Loan Vulliard 1 collaboration

Marion Russier 1 collaboration

Johanna B Brüggenthies 1 collaboration

Victoria Saferding 1 collaboration

Birgit Niederreiter 1 collaboration

Alexandra Junza 1 collaboration

Annika Frauenstein 1 collaboration

Carina Scholtysek 1 collaboration

Yohei Mikami 1 collaboration

Gerhard Krönke 1 collaboration

John J O'Shea 1 collaboration

Felix Meissner 1 collaboration

Josef S Smolen 1 collaboration

Paul Cheng 1 collaboration

Oscar Yanes 1 collaboration

Peter J Murray 1 collaboration

Stephan Blüml 1 collaboration

Christoph Buchta 1 collaboration

Jeremy V Camp 1 collaboration

Jovana Jovanovic 1 collaboration

Peter Chiba 1 collaboration

Maximilian Mayerhofer 1 collaboration

Helga Plicka 1 collaboration

Wolfgang Huf 1 collaboration

Bernhard Benka 1 collaboration

Vincent Delatour 1 collaboration

Mathias M Müller 1 collaboration

Andrea Griesmacher 1 collaboration

Irene Görzer 1 collaboration

Anannya Bhattacharya 1 collaboration

Moritz F Schlapansky 1 collaboration

Bettina Gürtl 1 collaboration

Dijana Vitko 1 collaboration

Theresa Pinter 1 collaboration

Anna Orlova 1 collaboration

Natalia Pikor 1 collaboration

Daniela Reil 1 collaboration

Maria Ozsvár-Kozma 1 collaboration

Ulrich Kalinke 1 collaboration

Burkhard Ludewig 1 collaboration

Richard Moriggl 1 collaboration

Keiryn L Bennett 1 collaboration

Paul N Cheng 1 collaboration

Shuan Rao 1 collaboration

Laura Mondragón 1 collaboration

Blanka Pranjic 1 collaboration

Toshikatsu Hanada 1 collaboration

Gautier Stoll 1 collaboration

Thomas Köcher 1 collaboration

Peng Zhang 1 collaboration

Alexander Jais 1 collaboration

Daniel Schramek 1 collaboration

Katharina Haigh 1 collaboration

Valentina Sica 1 collaboration

Marion Leduc 1 collaboration

Nazanine Modjtahedi 1 collaboration

Tsung-Pin Pai 1 collaboration

Masahiro Onji 1 collaboration

Iris Uribesalgo 1 collaboration

Reiko Hanada 1 collaboration

Ivona Kozieradzki 1 collaboration

Rubina Koglgruber 1 collaboration

Shane J Cronin 1 collaboration

Zhigang She 1 collaboration

Franz Quehenberger 1 collaboration

Helmut Popper 1 collaboration

Lukas Kenner 1 collaboration

Jody J Haigh 1 collaboration

Oliver Kepp 1 collaboration

Malgorzata Rak 1 collaboration

Kaican Cai 1 collaboration

Guido Kroemer 1 collaboration

Josef M Penninger 1 collaboration

Michael Moschinger 1 collaboration

Haifeng Xu 1 collaboration

Thomas Scherer 1 collaboration

Suchira Gallage 1 collaboration

Adnan Ali 1 collaboration

Bojan Vilagos 1 collaboration

Joachim Friske 1 collaboration

Doron Merkler 1 collaboration

Alan Aderem 1 collaboration

Thomas H Helbich 1 collaboration

Mathias Heikenwälder 1 collaboration

Philipp A Lang 1 collaboration

Rudolf Zechner 1 collaboration

Christiane A Opitz 1 collaboration

Tobias V Lanz 1 collaboration

Michael Platten 1 collaboration

Ci Zhu 1 collaboration

Nicole Boucheron 1 collaboration

André C Müller 1 collaboration

Thierry Claudel 1 collaboration

Emina Halilbasic 1 collaboration

Daniela Hainberger 1 collaboration

Teresa Preglej 1 collaboration

Lisa Sandner 1 collaboration

Marlis Alteneder 1 collaboration

Alexandra F Gülich 1 collaboration

Matarr Khan 1 collaboration

Patricia Hamminger 1 collaboration

Jelena Remetic 1 collaboration

Anna Ohradanova-Repic 1 collaboration

Philipp Schatzlmaier 1 collaboration

Clemens Donner 1 collaboration

Claudia D Fuchs 1 collaboration

Tatjana Stojakovic 1 collaboration

Hubert Scharnagl 1 collaboration

Shinya Sakaguchi 1 collaboration

Wilfried Ellmeier 1 collaboration

Trinity Zang 1 collaboration

Edmund Osei Kuffour 1 collaboration

Viren A Baharani 1 collaboration

Marie Canis 1 collaboration

Fabian Schmidt 1 collaboration

Justin Da Silva 1 collaboration

Pooja Chaudhary 1 collaboration

Anna Gazumyan 1 collaboration

Ileana C Miranda 1 collaboration

Margaret R MacDonald 1 collaboration

Michel C Nussenzweig 1 collaboration

Theodora Hatziioannou 1 collaboration

Paul D Bieniasz 1 collaboration

Arjun Ravishankar 1 collaboration

Siddhartha Sharma 1 collaboration

Christopher N Parkhurst 1 collaboration

Simon A Grassmann 1 collaboration

Claire K Wingert 1 collaboration

Paoline Laurent 1 collaboration

Sai Ma 1 collaboration

Lucinda Paddock 1 collaboration

Isabella C Miranda 1 collaboration

Emin Onur Karakaslar 1 collaboration

Djamel Nehar-Belaid 1 collaboration

Asa Thibodeau 1 collaboration

Vinay K Kartha 1 collaboration

Jim K Yee 1 collaboration

Minh Y Mays 1 collaboration

Andrew W Daman 1 collaboration

Alexia Martinez de Paz 1 collaboration

Dughan Ahimovic 1 collaboration

Victor Ramos 1 collaboration

Erik Nielsen 1 collaboration

Sergio Alvarez-Mulett 1 collaboration

Ling Zheng 1 collaboration

Andrew Earl 1 collaboration

Alisha Yallowitz 1 collaboration

Lexi Robbins 1 collaboration

Elyse LaFond 1 collaboration

Karissa L Weidman 1 collaboration

Sabrina Racine-Brzostek 1 collaboration

He S Yang 1 collaboration

David R Price 1 collaboration

Louise Leyre 1 collaboration

Hiranmayi Ravichandran 1 collaboration

Junbum Kim 1 collaboration

Alain C Borczuk 1 collaboration

R Brad Jones 1 collaboration

Edward J Schenck 1 collaboration

Robert J Kaner 1 collaboration

Amy Chadburn 1 collaboration

Zhen Zhao 1 collaboration

Virginia Pascual 1 collaboration

Olivier Elemento 1 collaboration

Robert E Schwartz 1 collaboration

Jason D Buenrostro 1 collaboration

Rachel E Niec 1 collaboration

Franck J Barrat 1 collaboration

Lindsay Lief 1 collaboration

Joseph C Sun 1 collaboration

Duygu Ucar 1 collaboration

Tyler Lewy 1 collaboration

Thomas Krausgruber 1 collaboration

Nikolaus Fortelny 1 collaboration

Victoria Fife-Gernedl 1 collaboration

Linda C Schuster 1 collaboration

Amelie Nemc 1 collaboration

Christian Schmidl 1 collaboration

Ana Korosec 1 collaboration

Marlene Pühringer 1 collaboration

Alexander Hajto 1 collaboration

Lucia Quemada Garrido 1 collaboration

Mario Kuttke 1 collaboration

Ildiko Mesteri 1 collaboration

Maria W Górna 1 collaboration

Marta Kulik 1 collaboration

Paulina M Dominiak 1 collaboration

Amanda E Brandon 1 collaboration

Emma Estevez 1 collaboration

Casey L Egan 1 collaboration

Florian Gruber 1 collaboration

Mark A Febbraio 1 collaboration

Michael D Nicholson 1 collaboration

Daniela Schmid 1 collaboration

Henrique Colaço 1 collaboration

Michael Schuster 1 collaboration

Miguel L Grau 1 collaboration

Francisco Martínez-Jiménez 1 collaboration

Oriol Pich 1 collaboration

Wegene Borena 1 collaboration

Zsofia Keszei 1 collaboration

Jan Laine 1 collaboration

Monika Redlberger-Fritz 1 collaboration

Mario Karolyi 1 collaboration

Sabine Maritschnik 1 collaboration

Martin Borkovec 1 collaboration

Peter Hufnagl 1 collaboration

Manfred Nairz 1 collaboration

Günter Weiss 1 collaboration

Michael T Wolfinger 1 collaboration

Dorothee von Laer 1 collaboration

Giulio Superti-Furga 1 collaboration

Nuria Lopez-Bigas 1 collaboration

Franziska Michor 1 collaboration

Duygu Demiroz 1 collaboration

Ekaterini Platanitis 1 collaboration

Michael Bryant 1 collaboration

Philipp Fischer 1 collaboration

Michaela Prchal-Murphy 1 collaboration

Caroline Lassnig 1 collaboration

Manuela Baccarini 1 collaboration

Mathias Müller 1 collaboration

Veronika Sexl 1 collaboration

Marlies Dolezal 1 collaboration

Thomas Decker 1 collaboration