Epigenetic memory of coronavirus infection in innate immune cells and their progenitors.
COVID-19
IL-6
PASC
epigenetic memory
epigenome
hematopoietic stem and progenitor cells
monocytes
peripheral blood mononuclear cell progenitor input enrichment
post-acute sequelae SARS-CoV-2 infection
single-cell
trained immunity
transcriptome
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
31 08 2023
31 08 2023
Historique:
received:
17
08
2022
revised:
20
04
2023
accepted:
12
07
2023
pmc-release:
31
08
2024
medline:
4
9
2023
pubmed:
20
8
2023
entrez:
19
8
2023
Statut:
ppublish
Résumé
Inflammation can trigger lasting phenotypes in immune and non-immune cells. Whether and how human infections and associated inflammation can form innate immune memory in hematopoietic stem and progenitor cells (HSPC) has remained unclear. We found that circulating HSPC, enriched from peripheral blood, captured the diversity of bone marrow HSPC, enabling investigation of their epigenomic reprogramming following coronavirus disease 2019 (COVID-19). Alterations in innate immune phenotypes and epigenetic programs of HSPC persisted for months to 1 year following severe COVID-19 and were associated with distinct transcription factor (TF) activities, altered regulation of inflammatory programs, and durable increases in myelopoiesis. HSPC epigenomic alterations were conveyed, through differentiation, to progeny innate immune cells. Early activity of IL-6 contributed to these persistent phenotypes in human COVID-19 and a mouse coronavirus infection model. Epigenetic reprogramming of HSPC may underlie altered immune function following infection and be broadly relevant, especially for millions of COVID-19 survivors.
Identifiants
pubmed: 37597510
pii: S0092-8674(23)00796-1
doi: 10.1016/j.cell.2023.07.019
pmc: PMC10638861
mid: NIHMS1925619
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3882-3902.e24Subventions
Organisme : NIAID NIH HHS
ID : R01 AI142086
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI161444
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI144301
Pays : United States
Organisme : NCI NIH HHS
ID : R25 CA233208
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI148416
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK121072
Pays : United States
Organisme : NIGMS NIH HHS
ID : RM1 GM139738
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI132447
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests J.D.B. holds patents related to ATAC-seq and scATAC-seq and serves on the Scientific Advisory Board of CAMP4 Therapeutics, seqWell, and CelSee. S.Z.J. and F.J.B. declare a related patent application: 10203-02-PC; EFS ID: 44924864 Enrichment and Characterization of Rare Circulating Cells, including Progenitor Cells from Peripheral Blood and Uses Thereof. F.J.B. is a co-founder and scientific advisor of IpiNovyx Bio. E.J.S. reports personal fees from NIAID through Axle Informatics for the subject matter expert program for the COVID-19 vaccine clinical trials. R.E.S. is on the scientific advisory board of Miromatrix Inc. and Lime Therapeutics and is a paid consultant and speaker for Alnylam Inc.
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