Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19.
Adult
Aged
Betacoronavirus
/ immunology
Biomarkers
/ blood
COVID-19
Coronavirus Infections
/ blood
Cyclooxygenase 2
/ immunology
Disease Progression
Female
Host Microbial Interactions
/ immunology
Humans
Immunity, Innate
Inflammation Mediators
/ blood
Ki-67 Antigen
/ immunology
Longitudinal Studies
Male
Middle Aged
Monocytes
/ immunology
Pandemics
Pneumonia, Viral
/ blood
Prospective Studies
SARS-CoV-2
Severity of Illness Index
United Kingdom
/ epidemiology
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
17 09 2020
17 09 2020
Historique:
received:
02
07
2020
accepted:
14
09
2020
entrez:
18
9
2020
pubmed:
19
9
2020
medline:
30
9
2020
Statut:
ppublish
Résumé
COVID-19 pathogenesis is associated with an exaggerated immune response. However, the specific cellular mediators and inflammatory components driving diverse clinical disease outcomes remain poorly understood. We undertook longitudinal immune profiling on both whole blood and peripheral blood mononuclear cells (PBMCs) of hospitalized patients during the peak of the COVID-19 pandemic in the UK. Here, we report key immune signatures present shortly after hospital admission that were associated with the severity of COVID-19. Immune signatures were related to shifts in neutrophil to T cell ratio, elevated serum IL-6, MCP-1 and IP-10, and most strikingly, modulation of CD14
Identifiants
pubmed: 32943497
pii: 5/51/eabd6197
doi: 10.1126/sciimmunol.abd6197
pmc: PMC7857390
pii:
doi:
Substances chimiques
Biomarkers
0
Inflammation Mediators
0
Ki-67 Antigen
0
MKI67 protein, human
0
Cyclooxygenase 2
EC 1.14.99.1
PTGS2 protein, human
EC 1.14.99.1
Types de publication
Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/R00191X/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 20606/Z/17/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 202865/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106898/A/15/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L011840/1
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 21927
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Investigateurs
Alex Horsley
(A)
Tim Harrison
(T)
Joanna Porter
(J)
Ratko Djukanovic
(R)
Stefan Marciniak
(S)
Chris Brightling
(C)
Ling-Pei Ho
(LP)
Lorcan McGarvey
(L)
Jane Davies
(J)
Rohan Ahmed
(R)
Halima Ali Shuwa
(HA)
Miriam Avery
(M)
Katharine Birchall
(K)
Oliver Brand
(O)
Evelyn Charsley
(E)
Alistair Chenery
(A)
Christine Chew
(C)
Richard Clark
(R)
Emma Connolly
(E)
Karen Connolly
(K)
Simon Dawson
(S)
Laura Durrans
(L)
Hannah Durrington
(H)
Jasmine Egan
(J)
Claire Fox
(C)
Helen Francis
(H)
Miriam Franklin
(M)
Susannah Glasgow
(S)
Nicola Godfrey
(N)
Kathryn J Gray
(KJ)
Seamus Grundy
(S)
Jacinta Guerin
(J)
Pamela Hackney
(P)
Mudassar Iqbal
(M)
Chantelle Hayes
(C)
Emma Hardy
(E)
Jade Harris
(J)
Anu John
(A)
Bethany Jolly
(B)
Verena Kästele
(V)
Saba Khan
(S)
Gabriella Lindergard
(G)
Sylvia Lui
(S)
Lesley Lowe
(L)
Alex G Mathioudakis
(AG)
Flora A McClure
(FA)
Joanne Mitchell
(J)
Clare Moizer
(C)
Katrina Moore
(K)
David J Morgan
(DJ)
Stuart Moss
(S)
Syed Murtuza Baker
(SM)
Rob Oliver
(R)
Grace Padden
(G)
Christina Parkinson
(C)
Laurence Pearmain
(L)
Mike Phuycharoen
(M)
Ananya Saha
(A)
Barbora Salcman
(B)
Nicholas A Scott
(NA)
Seema Sharma
(S)
Jane Shaw
(J)
Joanne Shaw
(J)
Elizabeth Shepley
(E)
Lara Smith
(L)
Simon Stephan
(S)
Ruth Stephens
(R)
Gael Tavernier
(G)
Rhys Tudge
(R)
Louis Wareing
(L)
Roanna Warren
(R)
Thomas Williams
(T)
Lisa Willmore
(L)
Mehwish Younas
(M)
Informations de copyright
Copyright © 2020, American Association for the Advancement of Science.
Références
Ann Pharmacother. 2014 Jan;48(1):77-85
pubmed: 24259637
Crit Care. 2010;14(5):R167
pubmed: 20840779
J Med Virol. 2020 Oct;92(10):1733-1734
pubmed: 32242950
JCI Insight. 2017 Apr 6;2(7):e91868
pubmed: 28405622
J Immunol. 2010 Sep 15;185(6):3694-701
pubmed: 20713883
Am J Hematol. 2020 Jul;95(7):834-847
pubmed: 32282949
Nat Rev Immunol. 2020 Jun;20(6):343-344
pubmed: 32327719
Intensive Care Med. 2020 May;46(5):846-848
pubmed: 32125452
J Transl Med. 2020 May 20;18(1):206
pubmed: 32434518
Science. 2020 Sep 4;369(6508):
pubmed: 32669297
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Am J Respir Crit Care Med. 2000 Oct;162(4 Pt 1):1466-73
pubmed: 11029363
JCI Insight. 2020 Jun 4;5(11):
pubmed: 32329756
Cell Host Microbe. 2020 Jun 10;27(6):992-1000.e3
pubmed: 32320677
Nat Rev Immunol. 2020 Jun;20(6):363-374
pubmed: 32346093
J Clin Invest. 2020 May 1;130(5):2620-2629
pubmed: 32217835
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Trends Immunol. 2017 May;38(5):345-357
pubmed: 28216309
FASEB J. 2014 Jul;28(7):3183-96
pubmed: 24652950
Nat Med. 2020 Jun;26(6):842-844
pubmed: 32398875
J Infect Dis. 2014 May 1;209(9):1331-42
pubmed: 24065148
Cell. 2020 Jun 25;181(7):1489-1501.e15
pubmed: 32473127
Clin Infect Dis. 2020 Jul 28;71(15):762-768
pubmed: 32161940
J Exp Med. 1978 Mar 1;147(3):952-7
pubmed: 632752
Science. 2004 Mar 5;303(5663):1532-5
pubmed: 15001782
Thromb Res. 2020 Aug;192:3-8
pubmed: 32407937
Science. 2020 Mar 27;367(6485):1434
pubmed: 32198292
Nat Rev Immunol. 2020 Jun;20(6):355-362
pubmed: 32376901
J Intensive Care. 2020 Apr 10;8:25
pubmed: 32308985
Aging (Albany NY). 2017 Apr;9(4):1307-1325
pubmed: 28448963
Clin Infect Dis. 2010 Mar 15;50(6):850-9
pubmed: 20136415
Annu Rev Med. 2015;66:311-28
pubmed: 25587654
JCI Insight. 2020 May 21;5(10):
pubmed: 32434986
Nature. 2020 Aug;584(7821):463-469
pubmed: 32717743
EBioMedicine. 2020 May;55:102763
pubmed: 32361250
Immunity. 2018 Oct 16;49(4):595-613
pubmed: 30332628
Int J Biochem Cell Biol. 2006;38(8):1417-28
pubmed: 16546436
Cell Mol Immunol. 2020 May;17(5):541-543
pubmed: 32203186
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143
J Exp Med. 2020 Jun 1;217(6):
pubmed: 32302401
Science. 2020 Aug 7;369(6504):718-724
pubmed: 32661059
Nat Rev Drug Discov. 2020 Apr;19(4):253-275
pubmed: 31969717
Br J Haematol. 2005 Nov;131(4):508-19
pubmed: 16281943
Nature. 2020 Mar;579(7798):265-269
pubmed: 32015508