Invasive group B Streptococcus among non-pregnant adults in Brussels-Capital Region, 2005-2019.
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents
/ pharmacology
Belgium
/ epidemiology
Drug Resistance, Bacterial
Female
Hospital Mortality
Humans
Incidence
Male
Middle Aged
Retrospective Studies
Risk Factors
Serogroup
Streptococcal Infections
/ epidemiology
Streptococcus agalactiae
/ classification
Tertiary Care Centers
Diabetes
Group B Streptococcus
Incidence
Invasive infections
Non-pregnant adults
Obesity
Serotypes
Vaccine
Journal
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
ISSN: 1435-4373
Titre abrégé: Eur J Clin Microbiol Infect Dis
Pays: Germany
ID NLM: 8804297
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
03
07
2020
accepted:
10
09
2020
pubmed:
19
9
2020
medline:
5
8
2021
entrez:
18
9
2020
Statut:
ppublish
Résumé
To assess the incidence, clinical, microbiological features and outcome of invasive Streptococcus agalactiae (GBS) infections in non-pregnant adults in three tertiary hospitals of the Brussels-Capital Region. All bacterial cultures positive for GBS, from 2005 to 2019 from 3 hospitals of the Brussels-Capital Region, were extracted, and only cases of invasive diseases were included. Medical files were retrospectively retrieved for risk factors, clinical manifestations and outcome and also antibiotic-susceptibility testing and GBS serotypes. Incidence rates were calculated based on the hospitals catchment populations. A total of 337 cases of GBS-invasive infections were included. The incidence of invasive GBS for the 3 hospitals increased from 3.7 to 8.2 cases per 100.000 inhabitants between 2009 and 2018 (p = 0.04). The most frequently identified risk factors were diabetes (36.8%), obesity (35.0%), cancer (21.7%), renal disease (20.8%), and advanced age (≥ 65 years; 47.2%). Isolated bacteremia (22%), osteoarticular infection (21.4%), abscesses (13.9%), and skin and soft tissue infections (18.4%) were the most frequent manifestations. Intensive care unit admission was required in 21.7% and overall mortality was 9.4%. All strains remained susceptible to penicillin over the years. Up to 20% of strains were resistant to clindamycin. Serotypes Ia, Ib, II, III, IV, and V represented 96.8% of the available serotypes (60/62). As reported in several countries, invasive GBS disease in non-pregnant adults represents an increasing burden, particularly among diabetic, obese, and elderly patients. Almost all serotypes identified are included in the upcoming hexavalent GBS conjugate vaccine.
Identifiants
pubmed: 32944894
doi: 10.1007/s10096-020-04041-0
pii: 10.1007/s10096-020-04041-0
pmc: PMC7498195
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
515-523Références
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