First Structure-Activity Relationship Study of Potent BLT2 Agonists as Potential Wound-Healing Promoters.

Animals CHO Cells Cell Survival / drug effects Cricetulus Drug Development / methods HaCaT Cells Hep G2 Cells Humans Keratinocytes / drug effects Molecular Structure Receptors, Leukotriene B4 / agonists Structure-Activity Relationship Wound Healing / drug effects

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
22 10 2020
Historique:
pubmed: 19 9 2020
medline: 29 12 2020
entrez: 18 9 2020
Statut: ppublish

Résumé

The first potent leukotriene B4 (LTB4) receptor type 2 (BLT2) agonists, endogenous 12(

Identifiants

DOI: 10.1021/acs.jmedchem.0c00588 PMID: 32946232
pubmed: 32946232
doi: 10.1021/acs.jmedchem.0c00588
doi:

Substances chimiques

LTB4R2 protein, human 0
Receptors, Leukotriene B4 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

11548-11572

Auteurs

Victor Hernandez-Olmos (V)

Branch for Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.

Jan Heering (J)

Branch for Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.

Viktoria Planz (V)

Institute of Pharmaceutical Technology and Buchmann Institute for Molecular Life Sciences, Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.

Ting Liu (T)

Branch for Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.

Alexander Kaps (A)

Branch for Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.

Rinusha Rajkumar (R)

Branch for Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.

Matthias Gramzow (M)

Branch for Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.

Astrid Kaiser (A)

Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.

Manfred Schubert-Zsilavecz (M)

Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.

Michael J Parnham (MJ)

Branch for Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.

Maike Windbergs (M)

Institute of Pharmaceutical Technology and Buchmann Institute for Molecular Life Sciences, Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.

Dieter Steinhilber (D)

Branch for Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.

Ewgenij Proschak (E)

Branch for Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
ORCID: 0000-0003-1961-1859

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › First Structure-Activity Relationship Study of...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules CHO › First Structure-Activity Relationship Study of...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › First Structure-Activity Relationship Study of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Cricetulus › First Structure-Activity Relationship Study of...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › First Structure-Activity Relationship Study of...
questionsmedicales.fr › Cellules › Cellules épithéliales › Kératinocytes › Cellules HaCaT › First Structure-Activity Relationship Study of...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Cellules HepG2 › First Structure-Activity Relationship Study of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › First Structure-Activity Relationship Study of...
questionsmedicales.fr › Cellules › Cellules épithéliales › Kératinocytes › First Structure-Activity Relationship Study of...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › First Structure-Activity Relationship Study of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs aux éicosanoïdes › Récepteurs aux leucotriènes › Récepteurs aux leucotriènes B4 › First Structure-Activity Relationship Study of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › First Structure-Activity Relationship Study of...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Cicatrisation de plaie › First Structure-Activity Relationship Study of...