The von Hippel-Lindau Tumor Suppressor Gene: Implications and Therapeutic Opportunities.
Journal
Cancer journal (Sudbury, Mass.)
ISSN: 1540-336X
Titre abrégé: Cancer J
Pays: United States
ID NLM: 100931981
Informations de publication
Date de publication:
Historique:
entrez:
18
9
2020
pubmed:
19
9
2020
medline:
28
9
2021
Statut:
ppublish
Résumé
The discovery of the von Hippel-Lindau (VHL) gene marked a milestone in our understanding of clear cell renal cell carcinoma (ccRCC) pathogenesis. VHL inactivation is not only a defining feature of ccRCC, but also the initiating event. Herein, we discuss canonical and noncanonical pVHL functions, as well as breakthroughs shaping our understanding of ccRCC evolution and evolutionary subtypes. We conclude by presenting evolving strategies to therapeutically exploit effector mechanisms downstream of pVHL.
Identifiants
pubmed: 32947307
doi: 10.1097/PPO.0000000000000480
pii: 00130404-202009000-00005
pmc: PMC9812266
mid: NIHMS1848441
doi:
Substances chimiques
Von Hippel-Lindau Tumor Suppressor Protein
EC 2.3.2.27
VHL protein, human
EC 6.3.2.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
390-398Subventions
Organisme : NCI NIH HHS
ID : P50 CA196516
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA211732
Pays : United States
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