Transcriptomic and clonal characterization of T cells in the human central nervous system.
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
18 09 2020
18 09 2020
Historique:
received:
24
03
2020
accepted:
26
08
2020
entrez:
19
9
2020
pubmed:
20
9
2020
medline:
11
1
2022
Statut:
ppublish
Résumé
T cells provide critical immune surveillance to the central nervous system (CNS), and the cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further characterization of the state of T cells in the CSF in healthy individuals is important for understanding how T cells provide protective immune surveillance without damaging the delicate environment of the CNS and providing tissue-specific context for understanding immune dysfunction in neuroinflammatory disease. Here, we have profiled T cells in the CSF of healthy human donors and have identified signatures related to cytotoxic capacity and tissue adaptation that are further exemplified in clonally expanded CSF T cells. By comparing profiles of clonally expanded T cells obtained from the CSF of patients with multiple sclerosis (MS) and healthy donors, we report that clonally expanded T cells from the CSF of patients with MS have heightened expression of genes related to T cell activation and cytotoxicity.
Identifiants
pubmed: 32948672
pii: 5/51/eabb8786
doi: 10.1126/sciimmunol.abb8786
pmc: PMC8567322
mid: NIHMS1657097
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R01 CA227473
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI039671
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA121974
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI089992
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI073748
Pays : United States
Organisme : NINDS NIH HHS
ID : R25 NS079193
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI045757
Pays : United States
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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