Retro-inverso D-peptides as a novel targeted immunotherapy for Type 1 diabetes.
Animals
Antigen Presentation
/ drug effects
B-Lymphocytes
/ immunology
CD4-Positive T-Lymphocytes
/ drug effects
Cell Line
Diabetes Mellitus, Type 1
/ drug therapy
Female
HLA-DQ Antigens
/ immunology
Humans
Insulin-Secreting Cells
/ immunology
Lymphocyte Activation
/ drug effects
Male
Mice
Mice, Transgenic
Molecular Dynamics Simulation
Peptides
/ antagonists & inhibitors
Recombinant Proteins
/ immunology
HLA-DQ8
InsB:9-23
RI-D-peptides
Type 1 diabetes
Journal
Journal of autoimmunity
ISSN: 1095-9157
Titre abrégé: J Autoimmun
Pays: England
ID NLM: 8812164
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
24
05
2020
revised:
29
08
2020
accepted:
30
08
2020
pubmed:
22
9
2020
medline:
12
10
2021
entrez:
21
9
2020
Statut:
ppublish
Résumé
Over the past four decades, the number of people with Type 1 Diabetes (T1D) has increased by 4% per year, making it an important public health challenge. Currently, no curative therapy exists for T1D and the only available treatment is insulin replacement. HLA-DQ8 has been shown to present antigenic islet peptides driving the activation of CD4
Identifiants
pubmed: 32951964
pii: S0896-8411(20)30169-4
doi: 10.1016/j.jaut.2020.102543
pmc: PMC7683378
mid: NIHMS1629953
pii:
doi:
Substances chimiques
HLA-DQ Antigens
0
HLA-DQ8 antigen
0
InsB9-23 peptide
0
Peptides
0
Recombinant Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102543Subventions
Organisme : NCATS NIH HHS
ID : KL2 TR002558
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020541
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK067555
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002556
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Références
J Exp Med. 2012 Jan 16;209(1):51-60
pubmed: 22213807
Autoimmun Rev. 2002 May;1(3):139-45
pubmed: 12849007
Clin Exp Immunol. 2007 Apr;148(1):1-16
pubmed: 17349009
Lancet Diabetes Endocrinol. 2020 Mar;8(3):226-238
pubmed: 31999944
Nat Rev Immunol. 2013 Apr;13(4):243-56
pubmed: 23524461
Diabetes. 2001 May;50(5):1200-5
pubmed: 11334427
J Exp Med. 1993 Jan 1;177(1):119-25
pubmed: 8380294
J Clin Invest. 2010 May;120(5):1578-90
pubmed: 20407212
Semin Immunol. 2011 Jun;23(3):214-9
pubmed: 21852151
J Biol Chem. 2018 Oct 12;293(41):15748-15764
pubmed: 30131337
N Engl J Med. 2019 Aug 15;381(7):603-613
pubmed: 31180194
Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2656-61
pubmed: 24550292
J Clin Invest. 2007 Nov;117(11):3164-6
pubmed: 17975658
ACS Chem Biol. 2016 Apr 15;11(4):1058-65
pubmed: 26745345
Nanomedicine. 2017 Feb;13(2):723-732
pubmed: 27769888
Methods Mol Biol. 2018;1808:143-150
pubmed: 29956180
Endocrinology. 2008 Jul;149(7):3461-9
pubmed: 18388197
Diabetes. 2017 Mar;66(3):722-734
pubmed: 27920090
Lancet. 2018 Jan 20;391(10117):195
pubmed: 30277879
Lancet. 2014 Jan 4;383(9911):69-82
pubmed: 23890997
Ann N Y Acad Sci. 2006 Oct;1079:289-99
pubmed: 17130568
Neoplasia. 2011 Feb;13(2):120-30
pubmed: 21403838
Endocrinol Metab Clin North Am. 2013 Dec;42(4):747-87
pubmed: 24286949
Diabetes Care. 2010 May;33(5):1004-8
pubmed: 20200306
Drug Discov Today. 2010 Jan;15(1-2):40-56
pubmed: 19879957
Curr Opin Immunol. 2001 Dec;13(6):650-6
pubmed: 11677085
Curr Opin Pediatr. 2010 Aug;22(4):405-11
pubmed: 20489639
Sci Rep. 2017 Nov 20;7(1):15823
pubmed: 29158477
Drug Discov Today. 2015 Jan;20(1):122-8
pubmed: 25450771
Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14321-6
pubmed: 20660730
Hum Immunol. 2002 Nov;63(11):987-99
pubmed: 12392851
Mol Ther. 2018 Apr 04;26(4):996-1007
pubmed: 29503203
Chem Biol Drug Des. 2013 Jan;81(1):136-47
pubmed: 23253135
J Immunol. 2001 Jul 1;167(1):578-85
pubmed: 11418697
Circulation. 2019 Feb 5;139(6):730-743
pubmed: 30586738
Virol J. 2017 Dec 20;14(1):237
pubmed: 29258547
Nat Immunol. 2001 Jun;2(6):501-7
pubmed: 11376336
Tissue Antigens. 1994 Apr;43(4):242-8
pubmed: 7916168
Diabetes. 2008 Dec;57(12):3169-76
pubmed: 19033403
Clin J Am Soc Nephrol. 2017 Dec 7;12(12):2032-2045
pubmed: 28522654
FASEB J. 2001 Jan;15(1):31-33
pubmed: 11099487
Cell. 2019 May 30;177(6):1583-1599.e16
pubmed: 31150624
J Autoimmun. 2012 Dec;39(4):347-53
pubmed: 22647732
Endocrinol Metab Clin North Am. 2010 Sep;39(3):481-97
pubmed: 20723815
Nature. 2005 May 12;435(7039):220-3
pubmed: 15889095
J Clin Invest. 2018 May 1;128(5):1888-1902
pubmed: 29438107
J Clin Invest. 2007 Jul;117(7):1835-43
pubmed: 17607359
JAMA. 2014 May 7;311(17):1778-86
pubmed: 24794371
Chem Rec. 2016 Aug;16(4):1772-86
pubmed: 27255896
N Engl J Med. 2009 Nov 26;361(22):2143-52
pubmed: 19940299
Diabetes. 2002 May;51(5):1346-55
pubmed: 11978629
N Engl J Med. 2012 May 17;366(20):1870-80
pubmed: 22591293
J Immunol. 2013 Nov 15;191(10):5074-84
pubmed: 24123687
Front Immunol. 2019 Mar 08;10:365
pubmed: 30906293
N Engl J Med. 2002 May 30;346(22):1692-8
pubmed: 12037148
Eur J Immunol. 2000 Sep;30(9):2497-506
pubmed: 11009082
N Engl J Med. 2007 Oct 25;357(17):1731-43
pubmed: 17960014
HLA. 2018 Feb;91(2):88-101
pubmed: 29171935
J Autoimmun. 2005;25 Suppl:34-9
pubmed: 16263245
J Clin Invest. 2001 Jan;107(2):173-80
pubmed: 11160133
J Comput Chem. 2010 Nov 15;31(14):2658-68
pubmed: 20740566
Endocrinology. 2017 Feb 1;158(2):410-418
pubmed: 27929668
Immunity. 2012 Oct 19;37(4):611-21
pubmed: 23063329
J Autoimmun. 2018 Nov;94:7-15
pubmed: 30115527
Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):10954-10959
pubmed: 28874533
J Clin Invest. 2019 Jul 2;129(8):3045-3047
pubmed: 31264970
Nat Rev Dis Primers. 2016 Mar 17;2:16012
pubmed: 27159554
J Clin Invest. 2004 Aug;114(4):589-97
pubmed: 15314696
Diabetologia. 2000 Feb;43(2):210-7
pubmed: 10753043
PLoS One. 2010 Nov 10;5(11):e13863
pubmed: 21085664