Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups.

aliphatic fluorination cyclopropane isopropyl isostere lipophilicity oxetane

Journal

Beilstein journal of organic chemistry
ISSN: 1860-5397
Titre abrégé: Beilstein J Org Chem
Pays: Germany
ID NLM: 101250746

Informations de publication

Date de publication:
2020
Historique:
received: 19 07 2020
accepted: 20 08 2020
entrez: 21 9 2020
pubmed: 22 9 2020
medline: 22 9 2020
Statut: epublish

Résumé

A systematic comparison of lipophilicity modulations upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl substituents, at a single carbon atom, is provided using directly comparable, and easily accessible model compounds. In addition, comparison with relevant linear chain derivatives is provided, as well as lipophilicity changes occurring upon chain extension of acyclic precursors to give cyclopropyl containing compounds. For the compounds investigated, fluorination of the isopropyl substituent led to larger lipophilicity modulation compared to fluorination of the cyclopropyl substituent.

Identifiants

pubmed: 32952731
doi: 10.3762/bjoc.16.182
pmc: PMC7476584
doi:

Types de publication

Journal Article

Langues

eng

Pagination

2141-2150

Informations de copyright

Copyright © 2020, Jeffries et al.; licensee Beilstein-Institut.

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Auteurs

Benjamin Jeffries (B)

School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK.

Zhong Wang (Z)

School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK.

Robert I Troup (RI)

School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK.

Anaïs Goupille (A)

Université de Nantes, CNRS, CEISAM UMR 6230, F-44000 Nantes, France.

Jean-Yves Le Questel (JY)

Université de Nantes, CNRS, CEISAM UMR 6230, F-44000 Nantes, France.

Charlene Fallan (C)

Medicinal Chemistry, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK.

James S Scott (JS)

Medicinal Chemistry, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK.

Elisabetta Chiarparin (E)

Medicinal Chemistry, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, UK.

Jérôme Graton (J)

Université de Nantes, CNRS, CEISAM UMR 6230, F-44000 Nantes, France.

Bruno Linclau (B)

School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK.

Classifications MeSH