Charlene Fallan

Affiliations

Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom.

Publications (12)

Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors.

Bioorganic & medicinal chemistry

Avec: Sébastien L Degorce , Anna Aagaard , Rana Anjum , Iain A Cumming , Coura R Diène , Charlene Fallan , Tony Johnson , Karl-Johan Leuchowius , Alexandra L Orton , Stuart Pearson , Graeme R Robb , Alan Rosen , Graeme B Scarfe , James S Scott , James M Smith , Oliver R Steward , Ina Terstiege , Michael J Tucker , Paul Turner , Stephen D Wilkinson , Gail L Wrigley , Yafeng Xue

A Buchwald-Hartwig Protocol to Enable Rapid Linker Exploration of Cereblon E3-Ligase PROTACs*.

Chemistry (Weinheim an der Bergstrasse, Germany)

Avec: Thomas G Hayhow , Rachel E A Borrows , Coura R Diène , Gary Fairley , Charlene Fallan , Shaun M Fillery , James S Scott , David W Watson

Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro-8

ACS medicinal chemistry letters

Avec: Frederick W Goldberg , Attilla K T Ting , David Beattie , Gillian M Lamont , Charlene Fallan , M Raymond V Finlay , Beth Williamson , Marianne Schimpl , Alexander R Harmer , Oladipupo B Adeyemi , Pär Nordell , Anna S Cronin , Mercedes Vazquez-Chantada , Derek Barratt , Antonio Ramos-Montoya , Elaine B Cadogan , Barry R Davies

Proteolysis targeting chimeras (PROTACs) in 'beyond rule-of-five' chemical space: Recent progress and future challenges.

Bioorganic & medicinal chemistry letters

Avec: Scott D Edmondson , Bin Yang , Charlene Fallan

Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC.

Communications biology

Avec: Thomas G Hayhow , Beth Williamson , Mandy Lawson , Natalie Cureton , Erin L Braybrooke , Andrew Campbell , Rodrigo J Carbajo , Azadeh Cheraghchi-Bashi , Elisabetta Chiarparin , Coura R Diène , Charlene Fallan , David I Fisher , Frederick W Goldberg , Lorna Hopcroft , Philip Hopcroft , Anne Jackson , Jason G Kettle , Teresa Klinowska , Ulrike Künzel , Gillian Lamont , Hilary J Lewis , Gareth Maglennon , Scott Martin , Pablo Morentin Gutierrez , Christopher J Morrow , Myria Nikolaou , J Willem M Nissink , Patrick O'Shea , Radoslaw Polanski , Markus Schade , James S Scott , Aaron Smith , Judith Weber , Joanne Wilson , Bin Yang , Claire Crafter

Skipped Fluorination Motifs: Synthesis of Building Blocks and Comparison of Lipophilicity Trends with Vicinal and Isolated Fluorination Motifs.

The Journal of organic chemistry

Avec: Robert I Troup , Benjamin Jeffries , Raphael El-Bekri Saudain , Eleni Georgiou , Johanna Fish , James S Scott , Elisabetta Chiarparin , Charlene Fallan , Bruno Linclau

Current strategies for the design of PROTAC linkers: a critical review.

Exploration of targeted anti-tumor therapy

Avec: Robert I Troup , Charlene Fallan , Matthias G J Baud

The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-

Journal of medicinal chemistry

Avec: Frederick W Goldberg , M Raymond V Finlay , Attilla K T Ting , David Beattie , Gillian M Lamont , Charlene Fallan , Gail L Wrigley , Marianne Schimpl , Martin R Howard , Beth Williamson , Mercedes Vazquez-Chantada , Derek G Barratt , Barry R Davies , Elaine B Cadogan , Antonio Ramos-Montoya , Emma Dean

Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups.

Beilstein journal of organic chemistry

Avec: Benjamin Jeffries , Zhong Wang , Robert I Troup , Anaïs Goupille , Jean-Yves Le Questel , Charlene Fallan , James S Scott , Elisabetta Chiarparin , Jérôme Graton , Bruno Linclau

Visible Light-Mediated Cyclisation Reaction for the Synthesis of Highly-Substituted Tetrahydroquinolines and Quinolines.

Angewandte Chemie (International ed. in English)

Avec: Grant J Sherborne , Paul Kemmitt , Callum Prentice , Eli Zysman-Colman , Andrew D Smith , Charlene Fallan

Structural and Physicochemical Features of Oral PROTACs.

Journal of medicinal chemistry

Avec: Markus Schade , James S Scott , Thomas G Hayhow , Andy Pike , Ina Terstiege , Marie Ahlqvist , Johan R Johansson , Coura R Diene , Charlene Fallan , Amber Y S Balazs , Elisabetta Chiarparin , David Wilson

Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer.

Journal of medicinal chemistry

Avec: Sharan K Bagal , Peter C Astles , Coura Diène , Argyrides Argyrou , Claire Crafter , Doyle J Cassar , Charlene Fallan , Andreas Hock , Thomas Jones , Kevin Moreau , Gillian M Lamont , Scott Lamont , Chrysiis Michaloglou , Martin J Packer , Andy Pike , Antonio Ramos-Montoya , James S Scott , Joseph Shaw , Ziyanda Shologu

Réseau de co-auteurs

James S Scott 7 collaborations

Elisabetta Chiarparin 4 collaborations

Coura R Diène 3 collaborations

Thomas G Hayhow 3 collaborations

Frederick W Goldberg 3 collaborations

Gillian M Lamont 3 collaborations

Beth Williamson 3 collaborations

Antonio Ramos-Montoya 3 collaborations

Robert I Troup 3 collaborations

Ina Terstiege 2 collaborations

Gail L Wrigley 2 collaborations

Attilla K T Ting 2 collaborations

David Beattie 2 collaborations

M Raymond V Finlay 2 collaborations

Marianne Schimpl 2 collaborations

Mercedes Vazquez-Chantada 2 collaborations

Elaine B Cadogan 2 collaborations

Barry R Davies 2 collaborations

Bin Yang 2 collaborations

Markus Schade 2 collaborations

Claire Crafter 2 collaborations

Benjamin Jeffries 2 collaborations

Bruno Linclau 2 collaborations

Andy Pike 2 collaborations

Sébastien L Degorce 1 collaboration

Anna Aagaard 1 collaboration

Rana Anjum 1 collaboration

Iain A Cumming 1 collaboration

Tony Johnson 1 collaboration

Karl-Johan Leuchowius 1 collaboration

Alexandra L Orton 1 collaboration

Stuart Pearson 1 collaboration

Graeme R Robb 1 collaboration

Alan Rosen 1 collaboration

Graeme B Scarfe 1 collaboration

James M Smith 1 collaboration

Oliver R Steward 1 collaboration

Michael J Tucker 1 collaboration

Paul Turner 1 collaboration

Stephen D Wilkinson 1 collaboration

Yafeng Xue 1 collaboration

Rachel E A Borrows 1 collaboration

Gary Fairley 1 collaboration

Shaun M Fillery 1 collaboration

David W Watson 1 collaboration

Alexander R Harmer 1 collaboration

Oladipupo B Adeyemi 1 collaboration

Pär Nordell 1 collaboration

Anna S Cronin 1 collaboration

Derek Barratt 1 collaboration

Scott D Edmondson 1 collaboration

Mandy Lawson 1 collaboration

Natalie Cureton 1 collaboration

Erin L Braybrooke 1 collaboration

Andrew Campbell 1 collaboration

Rodrigo J Carbajo 1 collaboration

Azadeh Cheraghchi-Bashi 1 collaboration

David I Fisher 1 collaboration

Lorna Hopcroft 1 collaboration

Philip Hopcroft 1 collaboration

Anne Jackson 1 collaboration

Jason G Kettle 1 collaboration

Teresa Klinowska 1 collaboration

Ulrike Künzel 1 collaboration

Gillian Lamont 1 collaboration

Hilary J Lewis 1 collaboration

Gareth Maglennon 1 collaboration

Scott Martin 1 collaboration

Pablo Morentin Gutierrez 1 collaboration

Christopher J Morrow 1 collaboration

Myria Nikolaou 1 collaboration

J Willem M Nissink 1 collaboration

Patrick O'Shea 1 collaboration

Radoslaw Polanski 1 collaboration

Aaron Smith 1 collaboration

Judith Weber 1 collaboration

Joanne Wilson 1 collaboration

Raphael El-Bekri Saudain 1 collaboration

Eleni Georgiou 1 collaboration

Johanna Fish 1 collaboration

Matthias G J Baud 1 collaboration

Martin R Howard 1 collaboration

Derek G Barratt 1 collaboration

Emma Dean 1 collaboration

Zhong Wang 1 collaboration

Anaïs Goupille 1 collaboration

Jean-Yves Le Questel 1 collaboration

Jérôme Graton 1 collaboration

Grant J Sherborne 1 collaboration

Paul Kemmitt 1 collaboration

Callum Prentice 1 collaboration

Eli Zysman-Colman 1 collaboration

Andrew D Smith 1 collaboration

Marie Ahlqvist 1 collaboration

Johan R Johansson 1 collaboration

Coura R Diene 1 collaboration

Amber Y S Balazs 1 collaboration

David Wilson 1 collaboration

Sharan K Bagal 1 collaboration

Peter C Astles 1 collaboration

Coura Diène 1 collaboration

Argyrides Argyrou 1 collaboration

Doyle J Cassar 1 collaboration

Andreas Hock 1 collaboration

Thomas Jones 1 collaboration

Kevin Moreau 1 collaboration

Scott Lamont 1 collaboration

Chrysiis Michaloglou 1 collaboration

Martin J Packer 1 collaboration

Joseph Shaw 1 collaboration

Ziyanda Shologu 1 collaboration