Marianne Schimpl

Affiliations

Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0FZ, U.K.

Publications (19)

The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-

Journal of medicinal chemistry

Avec: Frederick W Goldberg , M Raymond V Finlay , Attilla K T Ting , David Beattie , Gillian M Lamont , Charlene Fallan , Gail L Wrigley , Marianne Schimpl , Martin R Howard , Beth Williamson , Mercedes Vazquez-Chantada , Derek G Barratt , Barry R Davies , Elaine B Cadogan , Antonio Ramos-Montoya , Emma Dean

PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling.

International journal of molecular sciences

Avec: Lotte van Beek , Éilís McClay , Saleha Patel , Marianne Schimpl , Laura Spagnolo , Taiana Maia de Oliveira

Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors.

Journal of the American Chemical Society

Avec: Kirsten McAulay , Emily A Hoyt , Morgan Thomas , Marianne Schimpl , Michael S Bodnarchuk , Hilary J Lewis , Derek Barratt , Deepa Bhavsar , David M Robinson , Michael J Deery , Derek J Ogg , Gonçalo J L Bernardes , Richard A Ward , Michael J Waring , Jason G Kettle

Correction: Mapping the binding sites of antibodies utilized in programmed cell death ligand-1 predictive immunohistochemical assays for use with immuno-oncology therapies.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Avec: Nicola L Lawson , Carly I Dix , Paul W Scorer , Christopher J Stubbs , Edmond Wong , Liam Hutchinson , Eileen J McCall , Marianne Schimpl , Emma DeVries , Jill Walker , Gareth H Williams , James Hunt , Craig Barker

Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy.

Journal of medicinal chemistry

Avec: J Willem M Nissink , Sana Bazzaz , Carolyn Blackett , Matthew A Clark , Olga Collingwood , Jeremy S Disch , Diana Gikunju , Kristin Goldberg , John P Guilinger , Elizabeth Hardaker , Edward J Hennessy , Rachael Jetson , Anthony D Keefe , William McCoull , Lindsay McMurray , Allison Olszewski , Ross Overman , Alexander Pflug , Marian Preston , Philip B Rawlins , Emma Rivers , Marianne Schimpl , Paul Smith , Caroline Truman , Elizabeth Underwood , Juli Warwicker , Jon Winter-Holt , Simon Woodcock , Ying Zhang

Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design.

Journal of medicinal chemistry

Avec: Taylor R Quinn , Kathryn A Giblin , Clare Thomson , Jeffrey A Boerth , Gayathri Bommakanti , Erin Braybrooke , Christina Chan , Alex J Chinn , Erin Code , Caifeng Cui , Yukai Fan , Neil P Grimster , Keishi Kohara , Michelle L Lamb , Lina Ma , Adelphe M Mfuh , Graeme R Robb , Kevin J Robbins , Marianne Schimpl , Haoran Tang , Jamie Ware , Gail L Wrigley , Lin Xue , Yun Zhang , Huimin Zhu , Samantha J Hughes

Mapping the binding sites of antibodies utilized in programmed cell death ligand-1 predictive immunohistochemical assays for use with immuno-oncology therapies.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-

Journal of medicinal chemistry

Avec: Jeffrey W Johannes , Amber Balazs , Derek Barratt , Michal Bista , Matthew D Chuba , Sabina Cosulich , Susan E Critchlow , Sébastien L Degorce , Paolo Di Fruscia , Scott D Edmondson , Kevin Embrey , Stephen Fawell , Avipsa Ghosh , Sonja J Gill , Anders Gunnarsson , Sudhir M Hande , Tom D Heightman , Paul Hemsley , Giuditta Illuzzi , Jordan Lane , Carrie Larner , Elisabetta Leo , Lina Liu , Andrew Madin , Scott Martin , Lisa McWilliams , Mark J O'Connor , Jonathan P Orme , Fiona Pachl , Martin J Packer , Xiaohui Pei , Andrew Pike , Marianne Schimpl , Hongyao She , Anna D Staniszewska , Verity Talbot , Elizabeth Underwood , Jeffrey G Varnes , Lin Xue , Tieguang Yao , Ke Zhang , Andrew X Zhang , Xiaolan Zheng

Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro-8

ACS medicinal chemistry letters

Avec: Frederick W Goldberg , Attilla K T Ting , David Beattie , Gillian M Lamont , Charlene Fallan , M Raymond V Finlay , Beth Williamson , Marianne Schimpl , Alexander R Harmer , Oladipupo B Adeyemi , Pär Nordell , Anna S Cronin , Mercedes Vazquez-Chantada , Derek Barratt , Antonio Ramos-Montoya , Elaine B Cadogan , Barry R Davies

Combining structural and coevolution information to unveil allosteric sites.

Chemical science

Avec: Giuseppina La Sala , Christopher Pfleger , Helena Käck , Lisa Wissler , Philip Nevin , Kerstin Böhm , Jon Paul Janet , Marianne Schimpl , Christopher J Stubbs , Marco De Vivo , Christian Tyrchan , Anders Hogner , Holger Gohlke , Andrey I Frolov

Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity.

ACS medicinal chemistry letters

Avec: Jeffrey A Boerth , Alex J Chinn , Marianne Schimpl , Gayathri Bommakanti , Christina Chan , Erin L Code , Kathryn A Giblin , Andrea Gohlke , Catherine S Hansel , Meizhong Jin , Stefan L Kavanagh , Michelle L Lamb , Jordan S Lane , Carrie J B Larner , Adelphe M Mfuh , Rachel K Moore , Taranee Puri , Taylor R Quinn , Minwei Ye , Kevin J Robbins , Miguel Gancedo-Rodrigo , Haoran Tang , Jarrod Walsh , Jamie Ware , Gail L Wrigley , Iswarya Karapa Reddy , Yun Zhang , Neil P Grimster

Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.

Nucleic acids research

Avec: Tom E H Ogden , Ji-Chun Yang , Marianne Schimpl , Laura E Easton , Elizabeth Underwood , Philip B Rawlins , Michael M McCauley , Marie-France Langelier , John M Pascal , Kevin J Embrey , David Neuhaus

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice.

Open biology

Avec: Villo Muha , Ritchie Williamson , Rachel Hills , Alison D McNeilly , Thomas G McWilliams , Jana Alonso , Marianne Schimpl , Aneika C Leney , Albert J R Heck , Calum Sutherland , Kevin D Read , Rory J McCrimmon , Simon P Brooks , Daan M F van Aalten

Development of a Series of Pyrrolopyridone MAT2A Inhibitors.

Journal of medicinal chemistry

Avec: Stephen J Atkinson , Sharan K Bagal , Argyrides Argyrou , Sean Askin , Tony Cheung , Elisabetta Chiarparin , Muireann Coen , Iain T Collie , Ian L Dale , Claudia De Fusco , Keith Dillman , Laura Evans , Lyman J Feron , Alison J Foster , Michael Grondine , Vasudev Kantae , Gillian M Lamont , Scott Lamont , James T Lynch , Sten Nilsson Lill , Graeme R Robb , Jamal Saeh , Marianne Schimpl , James S Scott , James Smith , Bharath Srinivasan , Sharon Tentarelli , Mercedes Vazquez-Chantada , David Wagner , Jarrod J Walsh , David Watson , Beth Williamson

Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models.

Journal of medicinal chemistry

Avec: Jon J Winter-Holt , Catherine Bardelle , Elisabetta Chiarparin , Ian L Dale , Paul R J Davey , Nichola L Davies , Christopher Denz , Shaun M Fillery , Carine M Guérot , Fujin Han , Samantha J Hughes , Meghana Kulkarni , Zhaoqun Liu , Alexander Milbradt , Thomas A Moss , Huijun Niu , Joe Patel , Alfred A Rabow , Marianne Schimpl , Junjie Shi , Dongqing Sun , Dejian Yang , Sylvie Guichard

Optimization of an Imidazo[1,2-

Journal of medicinal chemistry

Avec: William McCoull , Scott Boyd , Martin R Brown , Muireann Coen , Olga Collingwood , Nichola L Davies , Ann Doherty , Gary Fairley , Kristin Goldberg , Elizabeth Hardaker , Guang He , Edward J Hennessy , Philip Hopcroft , George Hodgson , Anne Jackson , Xiefeng Jiang , Ankur Karmokar , Anne-Laure Lainé , Nicola Lindsay , Yumeng Mao , Roshini Markandu , Lindsay McMurray , Neville McLean , Lorraine Mooney , Helen Musgrove , J Willem M Nissink , Alexander Pflug , Venkatesh Pilla Reddy , Philip B Rawlins , Emma Rivers , Marianne Schimpl , Graham F Smith , Sharon Tentarelli , Jon Travers , Robert I Troup , Josephine Walton , Cheng Wang , Stephen Wilkinson , Beth Williamson , Jon Winter-Holt , Dejian Yang , Yuting Zheng , Qianxiu Zhu , Paul D Smith

Fragment-Based Design of a Potent MAT2a Inhibitor and

Journal of medicinal chemistry

Avec: Claudia De Fusco , Marianne Schimpl , Ulf Börjesson , Tony Cheung , Iain Collie , Laura Evans , Priyanka Narasimhan , Christopher Stubbs , Mercedes Vazquez-Chantada , David J Wagner , Michael Grondine , Matthew G Sanders , Sharon Tentarelli , Elizabeth Underwood , Argyrides Argyrou , James M Smith , James T Lynch , Elisabetta Chiarparin , Graeme Robb , Sharan K Bagal , James S Scott

A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding.

The Biochemical journal

Avec: Alexander Pflug , Marianne Schimpl , J Willem M Nissink , Ross C Overman , Philip B Rawlins , Caroline Truman , Elizabeth Underwood , Juli Warwicker , Jon Winter-Holt , William McCoull

Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.

Journal of medicinal chemistry

Avec: Adelphe M Mfuh , Jeffrey A Boerth , Gayathri Bommakanti , Christina Chan , Alex J Chinn , Erin Code , Patrick J Fricke , Kathryn A Giblin , Andrea Gohlke , Catherine Hansel , Niresh Hariparsad , Samantha J Hughes , Meizhong Jin , Vasudev Kantae , Stefan L Kavanagh , Michelle L Lamb , Jordan Lane , Rachel Moore , Taranee Puri , Taylor R Quinn , Iswarya Reddy , Graeme R Robb , Kevin J Robbins , Miguel Gancedo Rodrigo , Marianne Schimpl , Baljinder Singh , Meha Singh , Haoran Tang , Clare Thomson , Jarrod J Walsh , Jamie Ware , Iain D G Watson , Min-Wei Ye , Gail L Wrigley , Andrew X Zhang , Yun Zhang , Neil P Grimster

Réseau de co-auteurs

Elizabeth Underwood 5 collaborations

Gail L Wrigley 4 collaborations

Beth Williamson 4 collaborations

Mercedes Vazquez-Chantada 4 collaborations

Philip B Rawlins 4 collaborations

Gillian M Lamont 3 collaborations

Derek Barratt 3 collaborations

Christopher J Stubbs 3 collaborations

J Willem M Nissink 3 collaborations

William McCoull 3 collaborations

Alexander Pflug 3 collaborations

Jon Winter-Holt 3 collaborations

Taylor R Quinn 3 collaborations

Kathryn A Giblin 3 collaborations

Jeffrey A Boerth 3 collaborations

Gayathri Bommakanti 3 collaborations

Christina Chan 3 collaborations

Alex J Chinn 3 collaborations

Neil P Grimster 3 collaborations

Michelle L Lamb 3 collaborations

Adelphe M Mfuh 3 collaborations

Graeme R Robb 3 collaborations

Kevin J Robbins 3 collaborations

Haoran Tang 3 collaborations

Jamie Ware 3 collaborations

Yun Zhang 3 collaborations

Samantha J Hughes 3 collaborations

Elisabetta Chiarparin 3 collaborations

Sharon Tentarelli 3 collaborations

Frederick W Goldberg 2 collaborations

M Raymond V Finlay 2 collaborations

Attilla K T Ting 2 collaborations

David Beattie 2 collaborations

Charlene Fallan 2 collaborations

Barry R Davies 2 collaborations

Elaine B Cadogan 2 collaborations

Antonio Ramos-Montoya 2 collaborations

Nicola L Lawson 2 collaborations

Carly I Dix 2 collaborations

Paul W Scorer 2 collaborations

Edmond Wong 2 collaborations

Liam Hutchinson 2 collaborations

Eileen J McCall 2 collaborations

Emma DeVries 2 collaborations

Jill Walker 2 collaborations

Gareth H Williams 2 collaborations

James Hunt 2 collaborations

Craig Barker 2 collaborations

Olga Collingwood 2 collaborations

Kristin Goldberg 2 collaborations

Elizabeth Hardaker 2 collaborations

Edward J Hennessy 2 collaborations

Lindsay McMurray 2 collaborations

Emma Rivers 2 collaborations

Caroline Truman 2 collaborations

Juli Warwicker 2 collaborations

Clare Thomson 2 collaborations

Erin Code 2 collaborations

Lin Xue 2 collaborations

Jordan Lane 2 collaborations

Andrew X Zhang 2 collaborations

Andrea Gohlke 2 collaborations

Meizhong Jin 2 collaborations

Stefan L Kavanagh 2 collaborations

Taranee Puri 2 collaborations

Sharan K Bagal 2 collaborations

Argyrides Argyrou 2 collaborations

Tony Cheung 2 collaborations

Muireann Coen 2 collaborations

Ian L Dale 2 collaborations

Claudia De Fusco 2 collaborations

Laura Evans 2 collaborations

Michael Grondine 2 collaborations

Vasudev Kantae 2 collaborations

James T Lynch 2 collaborations

James S Scott 2 collaborations

Jarrod J Walsh 2 collaborations

Nichola L Davies 2 collaborations

Dejian Yang 2 collaborations

Martin R Howard 1 collaboration

Derek G Barratt 1 collaboration

Emma Dean 1 collaboration

Lotte van Beek 1 collaboration

Éilís McClay 1 collaboration

Saleha Patel 1 collaboration

Laura Spagnolo 1 collaboration

Taiana Maia de Oliveira 1 collaboration

Kirsten McAulay 1 collaboration

Emily A Hoyt 1 collaboration

Morgan Thomas 1 collaboration

Michael S Bodnarchuk 1 collaboration

Hilary J Lewis 1 collaboration

Deepa Bhavsar 1 collaboration

David M Robinson 1 collaboration

Michael J Deery 1 collaboration

Derek J Ogg 1 collaboration

Gonçalo J L Bernardes 1 collaboration

Richard A Ward 1 collaboration

Michael J Waring 1 collaboration

Jason G Kettle 1 collaboration

Sana Bazzaz 1 collaboration

Carolyn Blackett 1 collaboration

Matthew A Clark 1 collaboration

Jeremy S Disch 1 collaboration

Diana Gikunju 1 collaboration

John P Guilinger 1 collaboration

Rachael Jetson 1 collaboration

Anthony D Keefe 1 collaboration

Allison Olszewski 1 collaboration

Ross Overman 1 collaboration

Marian Preston 1 collaboration

Paul Smith 1 collaboration

Simon Woodcock 1 collaboration

Ying Zhang 1 collaboration

Erin Braybrooke 1 collaboration

Caifeng Cui 1 collaboration

Yukai Fan 1 collaboration

Keishi Kohara 1 collaboration

Lina Ma 1 collaboration

Huimin Zhu 1 collaboration

Jeffrey W Johannes 1 collaboration

Amber Balazs 1 collaboration

Michal Bista 1 collaboration

Matthew D Chuba 1 collaboration

Sabina Cosulich 1 collaboration

Susan E Critchlow 1 collaboration

Sébastien L Degorce 1 collaboration

Paolo Di Fruscia 1 collaboration

Scott D Edmondson 1 collaboration

Kevin Embrey 1 collaboration

Stephen Fawell 1 collaboration

Avipsa Ghosh 1 collaboration

Sonja J Gill 1 collaboration

Anders Gunnarsson 1 collaboration

Sudhir M Hande 1 collaboration

Tom D Heightman 1 collaboration

Paul Hemsley 1 collaboration

Giuditta Illuzzi 1 collaboration

Carrie Larner 1 collaboration

Elisabetta Leo 1 collaboration

Lina Liu 1 collaboration

Andrew Madin 1 collaboration

Scott Martin 1 collaboration

Lisa McWilliams 1 collaboration

Mark J O'Connor 1 collaboration

Jonathan P Orme 1 collaboration

Fiona Pachl 1 collaboration

Martin J Packer 1 collaboration

Xiaohui Pei 1 collaboration

Andrew Pike 1 collaboration

Hongyao She 1 collaboration

Anna D Staniszewska 1 collaboration

Verity Talbot 1 collaboration

Jeffrey G Varnes 1 collaboration

Tieguang Yao 1 collaboration

Ke Zhang 1 collaboration

Xiaolan Zheng 1 collaboration

Alexander R Harmer 1 collaboration

Oladipupo B Adeyemi 1 collaboration

Pär Nordell 1 collaboration

Anna S Cronin 1 collaboration

Giuseppina La Sala 1 collaboration

Christopher Pfleger 1 collaboration

Helena Käck 1 collaboration

Lisa Wissler 1 collaboration

Philip Nevin 1 collaboration

Kerstin Böhm 1 collaboration

Jon Paul Janet 1 collaboration

Marco De Vivo 1 collaboration

Christian Tyrchan 1 collaboration

Anders Hogner 1 collaboration

Holger Gohlke 1 collaboration

Andrey I Frolov 1 collaboration

Erin L Code 1 collaboration

Catherine S Hansel 1 collaboration

Jordan S Lane 1 collaboration

Carrie J B Larner 1 collaboration

Rachel K Moore 1 collaboration

Minwei Ye 1 collaboration

Miguel Gancedo-Rodrigo 1 collaboration

Jarrod Walsh 1 collaboration

Iswarya Karapa Reddy 1 collaboration

Tom E H Ogden 1 collaboration

Ji-Chun Yang 1 collaboration

Laura E Easton 1 collaboration

Michael M McCauley 1 collaboration

Marie-France Langelier 1 collaboration

John M Pascal 1 collaboration

Kevin J Embrey 1 collaboration

David Neuhaus 1 collaboration

Villo Muha 1 collaboration

Ritchie Williamson 1 collaboration

Rachel Hills 1 collaboration

Alison D McNeilly 1 collaboration

Thomas G McWilliams 1 collaboration

Jana Alonso 1 collaboration

Aneika C Leney 1 collaboration

Albert J R Heck 1 collaboration

Calum Sutherland 1 collaboration

Kevin D Read 1 collaboration

Rory J McCrimmon 1 collaboration

Simon P Brooks 1 collaboration

Daan M F van Aalten 1 collaboration

Stephen J Atkinson 1 collaboration

Sean Askin 1 collaboration

Iain T Collie 1 collaboration

Keith Dillman 1 collaboration

Lyman J Feron 1 collaboration

Alison J Foster 1 collaboration

Scott Lamont 1 collaboration

Sten Nilsson Lill 1 collaboration

Jamal Saeh 1 collaboration

James Smith 1 collaboration

Bharath Srinivasan 1 collaboration

David Wagner 1 collaboration

David Watson 1 collaboration

Jon J Winter-Holt 1 collaboration

Catherine Bardelle 1 collaboration

Paul R J Davey 1 collaboration

Christopher Denz 1 collaboration

Shaun M Fillery 1 collaboration

Carine M Guérot 1 collaboration

Fujin Han 1 collaboration

Meghana Kulkarni 1 collaboration

Zhaoqun Liu 1 collaboration

Alexander Milbradt 1 collaboration

Thomas A Moss 1 collaboration

Huijun Niu 1 collaboration

Joe Patel 1 collaboration

Alfred A Rabow 1 collaboration

Junjie Shi 1 collaboration

Dongqing Sun 1 collaboration

Sylvie Guichard 1 collaboration

Scott Boyd 1 collaboration

Martin R Brown 1 collaboration

Ann Doherty 1 collaboration

Gary Fairley 1 collaboration

Guang He 1 collaboration

Philip Hopcroft 1 collaboration

George Hodgson 1 collaboration

Anne Jackson 1 collaboration

Xiefeng Jiang 1 collaboration

Ankur Karmokar 1 collaboration

Anne-Laure Lainé 1 collaboration

Nicola Lindsay 1 collaboration

Yumeng Mao 1 collaboration

Roshini Markandu 1 collaboration

Neville McLean 1 collaboration

Lorraine Mooney 1 collaboration

Helen Musgrove 1 collaboration

Venkatesh Pilla Reddy 1 collaboration

Graham F Smith 1 collaboration

Jon Travers 1 collaboration

Robert I Troup 1 collaboration

Josephine Walton 1 collaboration

Cheng Wang 1 collaboration

Stephen Wilkinson 1 collaboration

Yuting Zheng 1 collaboration

Qianxiu Zhu 1 collaboration

Paul D Smith 1 collaboration

Ulf Börjesson 1 collaboration

Iain Collie 1 collaboration

Priyanka Narasimhan 1 collaboration

Christopher Stubbs 1 collaboration

David J Wagner 1 collaboration

Matthew G Sanders 1 collaboration

James M Smith 1 collaboration

Graeme Robb 1 collaboration

Ross C Overman 1 collaboration

Patrick J Fricke 1 collaboration

Catherine Hansel 1 collaboration

Niresh Hariparsad 1 collaboration

Rachel Moore 1 collaboration

Iswarya Reddy 1 collaboration

Miguel Gancedo Rodrigo 1 collaboration

Baljinder Singh 1 collaboration

Meha Singh 1 collaboration

Iain D G Watson 1 collaboration

Min-Wei Ye 1 collaboration