Prenylated indole alkaloids and lignans from the flower buds of Tussilago farfara.
China
Flowers
/ chemistry
Free Radical Scavengers
/ isolation & purification
Glycoside Hydrolase Inhibitors
/ isolation & purification
Indole Alkaloids
/ isolation & purification
Lignans
/ isolation & purification
Molecular Structure
Phytochemicals
/ isolation & purification
Prenylation
Saccharomyces cerevisiae
/ enzymology
Tussilago
/ chemistry
alpha-Glucosidases
Antiradical
Indole alkaloid
Lignan
Tussilago farfara
α-Glucosidase
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
03
08
2020
revised:
15
09
2020
accepted:
16
09
2020
pubmed:
22
9
2020
medline:
18
3
2021
entrez:
21
9
2020
Statut:
ppublish
Résumé
Six new compounds including four prenylated indole alkaloids (1-4) and two lignans (5-6), along with eight known cometabolites (7-14), were isolated from the flower buds of Tussilago farfara. Structures of the new compounds were elucidated by comparison with structurally related known analogues and also by comprehensive spectroscopic analyses. Their absolute configurations were determined by a variety of means including Mosher's method, Marfey's analysis, electronic circular dichroism (ECD) exciton chirality method and ECD calculations. Our bioassays have established that compounds 1 and 2 showed potent α-glucosidase inhibitory activity with IC
Identifiants
pubmed: 32956711
pii: S0367-326X(20)30311-7
doi: 10.1016/j.fitote.2020.104729
pii:
doi:
Substances chimiques
Free Radical Scavengers
0
Glycoside Hydrolase Inhibitors
0
Indole Alkaloids
0
Lignans
0
Phytochemicals
0
alpha-Glucosidases
EC 3.2.1.20
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104729Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.