Nitric Oxide Inhibitory Carbazole Alkaloids from the Folk Medicine Murraya tetramera C.C. Huang.
Alkaloids
/ chemistry
Animals
Anti-Inflammatory Agents
/ chemistry
Carbazoles
/ chemistry
Cell Line
Lipopolysaccharides
/ pharmacology
Magnetic Resonance Spectroscopy
Medicine, Traditional
Mice
Microglia
/ cytology
Molecular Conformation
Murraya
/ chemistry
Nitric Oxide
/ metabolism
Plant Leaves
/ chemistry
Plant Stems
/ chemistry
Murraya
Murraya tetramera C.C. Huang
carbazole alkaloids
nitric oxide inhibition
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
23
06
2020
accepted:
22
09
2020
pubmed:
23
9
2020
medline:
26
5
2021
entrez:
22
9
2020
Statut:
ppublish
Résumé
The phytochemical investigation of the leaves and stems of Murraya tetramera C.C. Huang, a traditional folk medicine used as an anti-inflammatory agent, yielded 19 simple carbazole alkaloids, two of which (1-ethoxy-3-methyl-9H-carbazol-2-ol (1) and 7-hydroxy-2,8-dimethoxy-6-methyl-9H-carbazole-1-carbaldehyde (2)) are new ones. The structures of the new compounds were determined by extensive spectroscopic analysis including NMR and HR-EI-MS experiments, as well as comparison with the reported data. Most of the isolates showed potent inhibitory effects on NO production in LPS-stimulated BV-2 microglial cells with IC
Identifiants
pubmed: 32960486
doi: 10.1002/cbdv.202000490
doi:
Substances chimiques
Alkaloids
0
Anti-Inflammatory Agents
0
Carbazoles
0
Lipopolysaccharides
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000490Subventions
Organisme : National Natural Science Foundation of China
ID : 81973199
Organisme : National Natural Science Foundation of China
ID : 81773864
Organisme : National Natural Science Foundation of China
ID : 81473106
Organisme : Fundamental Research Funds for the Central Public Welfare Research Institutes
ID : ZXKT19025
Organisme : The Drug Innovation Project of China
ID : 2018ZX09711001-008-003
Informations de copyright
© 2020 Wiley-VHCA AG, Zurich, Switzerland.
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