Mortality and risk of tuberculosis among people living with HIV in whom TB was initially ruled out.
Adult
Coinfection
/ epidemiology
Female
HIV
/ isolation & purification
HIV Infections
/ epidemiology
Humans
Incidence
Male
Middle Aged
Mozambique
/ epidemiology
Mycobacterium tuberculosis
/ isolation & purification
Prognosis
Retrospective Studies
Risk Factors
Survival Rate
Tuberculosis
/ epidemiology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 09 2020
22 09 2020
Historique:
received:
15
01
2020
accepted:
31
07
2020
entrez:
23
9
2020
pubmed:
24
9
2020
medline:
16
12
2020
Statut:
epublish
Résumé
Tuberculosis (TB) misdiagnosis remains a public health concern, especially among people living with HIV (PLHIV), given the high mortality associated with missed TB diagnoses. The main objective of this study was to describe the all-cause mortality, TB incidence rates and their associated risk factors in a cohort of PLHIV with presumptive TB in whom TB was initially ruled out. We retrospectively followed a cohort of PLHIV with presumptive TB over a 2 year-period in a rural district in Southern Mozambique. During the study period 382 PLHIV were followed-up. Mortality rate was 6.8/100 person-years (PYs) (95% CI 5.2-9.2) and TB incidence rate was 5.4/100 PYs (95% CI 3.9-7.5). Thirty-six percent of deaths and 43% of TB incident cases occurred in the first 12 months of the follow up. Mortality and TB incidence rates in the 2-year period after TB was initially ruled out was very high. The TB diagnostic work-up and linkage to HIV care should be strengthened to decrease TB burden and all-cause mortality among PLHIV with presumptive TB.
Identifiants
pubmed: 32963296
doi: 10.1038/s41598-020-71784-3
pii: 10.1038/s41598-020-71784-3
pmc: PMC7509810
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15442Références
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