Loci identified by a genome-wide association study of carotid artery stenosis in the eMERGE network.

Carotid Stenosis Electronic Health Records Genetic Predisposition to Disease Genome-Wide Association Study Genomics Humans Lipoprotein(a) / genetics Models, Genetic Polymorphism, Single Nucleotide
carotid artery atherosclerosis electronic health records genome-wide association study

Journal

Genetic epidemiology
ISSN: 1098-2272
Titre abrégé: Genet Epidemiol
Pays: United States
ID NLM: 8411723

Informations de publication

Date de publication:
02 2021
Historique:
received: 27 04 2020
revised: 29 07 2020
accepted: 11 08 2020
pubmed: 24 9 2020
medline: 14 9 2021
entrez: 23 9 2020
Statut: ppublish

Résumé

Carotid artery atherosclerotic disease (CAAD) is a risk factor for stroke. We used a genome-wide association (GWAS) approach to discover genetic variants associated with CAAD in participants in the electronic Medical Records and Genomics (eMERGE) Network. We identified adult CAAD cases with unilateral or bilateral carotid artery stenosis and controls without evidence of stenosis from electronic health records at eight eMERGE sites. We performed GWAS with a model adjusting for age, sex, study site, and genetic principal components of ancestry. In eMERGE we found 1793 CAAD cases and 17,958 controls. Two loci reached genome-wide significance, on chr6 in LPA (rs10455872, odds ratio [OR] (95% confidence interval [CI]) = 1.50 (1.30-1.73), p = 2.1 × 10

Identifiants

DOI: 10.1002/gepi.22360 PMID: 32964493 PMC: PMC7891640
pubmed: 32964493
doi: 10.1002/gepi.22360
pmc: PMC7891640
doi:

Substances chimiques

Lipoprotein(a) 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4-15

Subventions

Organisme : NHGRI NIH HHS
ID : U01 HG006382
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG000040
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG004424
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006389
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006385
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG008676
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006375
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG004438
Pays : United States
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : U01 HG008657
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG008672
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG008684
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006828
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG008679
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006380
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG008666
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006388
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG008680
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006378
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002373
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG008673
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : U01 HG008685
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006379
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG008664
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG008701
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006830
Pays : United States

Informations de copyright

© 2020 The Authors. Genetic Epidemiology published by Wiley Periodicals LLC.

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Auteurs

Melody R Palmer (MR)

Division of Medical Genetics, School of Medicine, University of Washington, Seattle, Washington, USA.

Daniel S Kim (DS)

Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.

David R Crosslin (DR)

Department of Biomedical Informatics and Medical Education, School of Medicine, University of Washington, Seattle, Washington, USA.

Ian B Stanaway (IB)

Department of Biomedical Informatics and Medical Education, School of Medicine, University of Washington, Seattle, Washington, USA.
ORCID: 0000-0002-0783-0918

Elisabeth A Rosenthal (EA)

Division of Medical Genetics, School of Medicine, University of Washington, Seattle, Washington, USA.

David S Carrell (DS)

Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.

David J Cronkite (DJ)

Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.

Adam Gordon (A)

Center for Genetic Medicine, Northwestern University, Chicago, Illinois, USA.

Xiaomeng Du (X)

Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Yatong K Li (YK)

Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.

Marc S Williams (MS)

Genomic Medicine Institute, Geisinger, Danville, Pennsylvania, USA.

Chunhua Weng (C)

Department of Biomedical Informatics, Columbia University, New York, New York, USA.

Qiping Feng (Q)

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Rongling Li (R)

Division of Genomic Medicine, National Human Genome Research Institute, Bethesda, Maryland, USA.

Sarah A Pendergrass (SA)

Geisinger Research, Rockville, Maryland, USA.

Hakon Hakonarson (H)

Department of Pediatrics, The Center for Applied Genomics, Children's Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

David Fasel (D)

Department of Biomedical Informatics, Columbia University, New York, New York, USA.

Sunghwan Sohn (S)

Mayo Clinic, Rochester, Minnesota, USA.

Patrick Sleiman (P)

Department of Pediatrics, The Children's Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Samuel K Handelman (SK)

Division of Gastroenterology, Department of Internal Medicine and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.

Elizabeth Speliotes (E)

Division of Gastroenterology, Department of Internal Medicine and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.

Iftikhar J Kullo (IJ)

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Eric B Larson (EB)

Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.
The electronic Medical Records and GEnomics Network, NHGRI, NIH, Bethesda, Maryland, USA.

Gail P Jarvik (GP)

Division of Medical Genetics, School of Medicine, University of Washington, Seattle, Washington, USA.
ORCID: 0000-0002-6710-8708

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Classifications MeSH

questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Artériopathies carotidiennes › Sténose carotidienne › Loci identified by a genome-wide association...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Documents › Dossiers médicaux › Systèmes informatisés de dossiers médicaux › Dossiers médicaux électroniques › Loci identified by a genome-wide association...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Loci identified by a genome-wide association...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Loci identified by a genome-wide association...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Loci identified by a genome-wide association...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Loci identified by a genome-wide association...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Lipoprotéine (a) › Loci identified by a genome-wide association...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles génétiques › Loci identified by a genome-wide association...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Loci identified by a genome-wide association...