Serine-Selective Bioconjugation.
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
14 10 2020
14 10 2020
Historique:
pubmed:
24
9
2020
medline:
22
4
2021
entrez:
23
9
2020
Statut:
ppublish
Résumé
This Communication reports the first general method for rapid, chemoselective, and modular functionalization of serine residues in native polypeptides, which uses a reagent platform based on the P(V) oxidation state. This redox-economical approach can be used to append nearly any kind of cargo onto serine, generating a stable, benign, and hydrophilic phosphorothioate linkage. The method tolerates all other known nucleophilic functional groups of naturally occurring proteinogenic amino acids. A variety of applications can be envisaged by this expansion of the toolbox of site-selective bioconjugation methods.
Identifiants
pubmed: 32965106
doi: 10.1021/jacs.0c05595
pmc: PMC8350984
mid: NIHMS1730205
doi:
Substances chimiques
Amino Acids
0
Peptides
0
Phosphorothioate Oligonucleotides
0
Ubiquitin
0
Serine
452VLY9402
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17236-17242Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM118176
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR002551
Pays : United States
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