TG6 Auto-Antibodies in Dermatitis Herpetiformis.
TG2
TG3
TG6
celiac disease
dermatitis herpetiformis
gluten ataxia
gluten encephalopathy
gluten neuropathy
transglutaminase antibodies
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
21 Sep 2020
21 Sep 2020
Historique:
received:
24
07
2020
revised:
31
08
2020
accepted:
15
09
2020
entrez:
24
9
2020
pubmed:
25
9
2020
medline:
10
4
2021
Statut:
epublish
Résumé
Dermatitis herpetiformis (DH) is an extraintestinal manifestation of gluten sensitivity, in which an autoimmune response is directed against transglutaminase 3 (TG3), an epidermal transglutaminase. TG2 is the autoantigen in celiac disease (CD), defined by the presence of enteropathy, and TG6 is the autoantigen in neurological manifestations of gluten sensitivity. The interplay between B cell responses to these 3 transglutaminases in developing the clinical spectrum of disease manifestations is not completely understood. Also, the individual or combined diagnostic and predictive value of the respective autoantibodies is not fully explored. We examined the prevalence of TG6 antibodies in a cohort of patients with DH. TG6 positivity was found in 13/33 (39%), with IgA detected in 11 patients, IgG in 3, and both in 1. This was significantly higher compared to what is seen in the classic CD cases (14%) in a Finnish population. TG6 positive baseline samples constituted 60% of DH patients with no enteropathy (
Identifiants
pubmed: 32967363
pii: nu12092884
doi: 10.3390/nu12092884
pmc: PMC7551372
pii:
doi:
Substances chimiques
Autoantibodies
0
Immunoglobulin A
0
Immunoglobulin G
0
TGM6 protein, human
EC 2.3.2.13
Transglutaminases
EC 2.3.2.13
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Scand J Gastroenterol. 2015 Apr;50(4):387-92
pubmed: 25639558
Neurology. 2013 May 7;80(19):1740-5
pubmed: 23576621
Clin Gastroenterol Hepatol. 2019 Dec;17(13):2678-2686.e2
pubmed: 30885888
Clin Gastroenterol Hepatol. 2005 Apr;3(4):335-41
pubmed: 15822038
Amino Acids. 2010 Nov;39(5):1183-91
pubmed: 20300788
Nutrients. 2020 Feb 13;12(2):
pubmed: 32069794
Clin Chem. 2010 Apr;56(4):661-5
pubmed: 20022983
Lancet Neurol. 2010 Mar;9(3):318-30
pubmed: 20170845
J Pediatr Gastroenterol Nutr. 2018 Jan;66(1):64-68
pubmed: 28542044
Am J Gastroenterol. 2016 Apr;111(4):561-7
pubmed: 26832652
Mol Immunol. 2008 Mar;45(6):1782-91
pubmed: 17996305
J Immunol. 2013 Jun 15;190(12):5981-91
pubmed: 23690478
Nature. 2020 Feb;578(7796):600-604
pubmed: 32051586
Gastroenterology. 2012 Sep;143(3):698-707.e4
pubmed: 22750506
J Pediatr Gastroenterol Nutr. 2008 Oct;47(4):500-3
pubmed: 18852644
J Invest Dermatol. 2015 Feb;135(2):623-625
pubmed: 25178107
J Pediatr Gastroenterol Nutr. 2012 Jan;54(1):136-60
pubmed: 22197856
Neurology. 2001 Feb 13;56(3):385-8
pubmed: 11171906
J Immunol. 2011 Apr 1;186(7):4474-80
pubmed: 21335491
J Invest Dermatol. 2009 Nov;129(11):2728-30
pubmed: 19516268
J Exp Med. 2002 Mar 18;195(6):747-57
pubmed: 11901200
Br J Dermatol. 2015 Apr;172(4):1139-41
pubmed: 25196300
Ann Neurol. 2008 Sep;64(3):332-43
pubmed: 18825674
Nat Med. 1997 Jul;3(7):797-801
pubmed: 9212111
Autoimmune Dis. 2014;2014:237107
pubmed: 24804082
Nat Med. 2012 Feb 26;18(3):441-5
pubmed: 22366952
BMC Med. 2012 Feb 07;10:13
pubmed: 22313950