Tissue Tropisms of Avian Influenza A Viruses Affect Their Spillovers from Wild Birds to Pigs.
Animals
Animals, Wild
/ virology
Birds
/ virology
Cell Line
Epithelial Cells
/ virology
HEK293 Cells
Hemagglutinins
Humans
Influenza A virus
/ genetics
Influenza in Birds
/ transmission
Orthomyxoviridae Infections
/ transmission
Pandemics
Phylogeny
Respiratory System
/ virology
Swine
Tropism
Virus Replication
Virus Shedding
H4N6
avian influenza virus
avian viruses
host tropism
influenza A viruses
mixing vessel
risk assessment
spillover
swine influenza virus
swine upper respiratory tract
tissue tropism
transmission
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
23 11 2020
23 11 2020
Historique:
received:
04
05
2020
accepted:
19
09
2020
pubmed:
25
9
2020
medline:
26
1
2021
entrez:
24
9
2020
Statut:
epublish
Résumé
Wild aquatic birds maintain a large, genetically diverse pool of influenza A viruses (IAVs), which can be transmitted to lower mammals and, ultimately, humans. Through phenotypic analyses of viral replication efficiency, only a small set of avian IAVs were found to replicate well in epithelial cells of the swine upper respiratory tract, and these viruses were shown to infect and cause virus shedding in pigs. Such a phenotypic trait of the viral replication efficiency appears to emerge randomly and is distributed among IAVs across multiple avian species and geographic and temporal orders. It is not determined by receptor binding preference but is determined by other markers across genomic segments, such as those in the ribonucleoprotein complex. This study demonstrates that phenotypic variants of viral replication efficiency exist among avian IAVs but that only a few of these may result in viral shedding in pigs upon infection, providing opportunities for these viruses to become adapted to pigs, thus posing a higher potential risk for creating novel variants or detrimental reassortants within pig populations.
Identifiants
pubmed: 32967956
pii: JVI.00847-20
doi: 10.1128/JVI.00847-20
pmc: PMC7925198
pii:
doi:
Substances chimiques
Hemagglutinins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R21 AI135820
Pays : United States
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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