Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.

Animals Autophagy Cell Line, Tumor Female Genes, Neoplasm / genetics Genome / genetics Genomics Humans Interferon-gamma / immunology Male Mice NF-kappa B / metabolism Neoplasms / genetics Reproducibility of Results Signal Transduction T-Lymphocytes, Cytotoxic / immunology Tumor Escape / genetics

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
10 2020
Historique:
received: 09 09 2019
accepted: 30 06 2020
pubmed: 25 9 2020
medline: 12 1 2021
entrez: 24 9 2020
Statut: ppublish

Résumé

The genetic circuits that allow cancer cells to evade destruction by the host immune system remain poorly understood

Identifiants

DOI: 10.1038/s41586-020-2746-2 PMID: 32968282 PMC: PMC9014559
pubmed: 32968282
doi: 10.1038/s41586-020-2746-2
pii: 10.1038/s41586-020-2746-2
pmc: PMC9014559
mid: NIHMS1791173
doi:

Substances chimiques

NF-kappa B 0
Interferon-gamma 82115-62-6

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

120-126

Subventions

Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM130119
Pays : United States

Commentaires et corrections

Type : CommentIn

Références

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Auteurs

Keith A Lawson (KA)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Division of Urology, Department of Surgery, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

Cristovão M Sousa (CM)

Agios Pharmaceuticals, Cambridge, MA, USA.

Xiaoyu Zhang (X)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

Eiru Kim (E)

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
ORCID: 0000-0002-1901-5670

Rummy Akthar (R)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

Joseph J Caumanns (JJ)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.

Yuxi Yao (Y)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

Nicholas Mikolajewicz (N)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
ORCID: 0000-0002-7525-0384

Catherine Ross (C)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.

Kevin R Brown (KR)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
ORCID: 0000-0002-5514-2538

Abdelrahman Abou Zid (AA)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.

Zi Peng Fan (ZP)

Agios Pharmaceuticals, Cambridge, MA, USA.

Shirley Hui (S)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.

Jordan A Krall (JA)

Agios Pharmaceuticals, Cambridge, MA, USA.

Donald M Simons (DM)

Agios Pharmaceuticals, Cambridge, MA, USA.

Chloe J Slater (CJ)

Agios Pharmaceuticals, Cambridge, MA, USA.

Victor De Jesus (V)

Agios Pharmaceuticals, Cambridge, MA, USA.

Lujia Tang (L)

Agios Pharmaceuticals, Cambridge, MA, USA.

Richa Singh (R)

Agios Pharmaceuticals, Cambridge, MA, USA.

Joshua E Goldford (JE)

Agios Pharmaceuticals, Cambridge, MA, USA.

Sarah Martin (S)

Agios Pharmaceuticals, Cambridge, MA, USA.

Qian Huang (Q)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.

Elizabeth A Francis (EA)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.

Andrea Habsid (A)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.

Ryan Climie (R)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.

David Tieu (D)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.

Jiarun Wei (J)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.

Ren Li (R)

Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.

Amy Hin Yan Tong (AHY)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.

Michael Aregger (M)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
ORCID: 0000-0001-6443-9870

Katherine S Chan (KS)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.

Hong Han (H)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.

Xiaowei Wang (X)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.

Patricia Mero (P)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.

John H Brumell (JH)

Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
ORCID: 0000-0002-5802-7789

Antonio Finelli (A)

Division of Urology, Department of Surgery, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

Laurie Ailles (L)

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
ORCID: 0000-0001-7289-8882

Gary Bader (G)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
ORCID: 0000-0003-0185-8861

Gromoslaw A Smolen (GA)

Agios Pharmaceuticals, Cambridge, MA, USA.
Celsius Therapeutics, Cambridge, MA, USA.
ORCID: 0000-0003-0136-4685

Gillian A Kingsbury (GA)

Agios Pharmaceuticals, Cambridge, MA, USA.

Traver Hart (T)

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Charles Kung (C)

Agios Pharmaceuticals, Cambridge, MA, USA.

Jason Moffat (J)

Donnelly Centre, University of Toronto, Toronto, Ontario, Canada. j.moffat@utoronto.ca.
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. j.moffat@utoronto.ca.
Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada. j.moffat@utoronto.ca.
ORCID: 0000-0002-5663-8586

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Functional genomic landscape of...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › Functional genomic landscape of...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Functional genomic landscape of...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes tumoraux › Functional genomic landscape of...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Functional genomic landscape of...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Functional genomic landscape of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Functional genomic landscape of...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › Functional genomic landscape of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Functional genomic landscape of...
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questionsmedicales.fr › Tumeurs › Functional genomic landscape of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Functional genomic landscape of...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Functional genomic landscape of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T cytotoxiques › Functional genomic landscape of...
questionsmedicales.fr › Phénomènes du système immunitaire › Échappement de la tumeur à la surveillance immunitaire › Functional genomic landscape of...