Growth arrest-specific 6 modulates adiponectin expression and insulin resistance in adipose tissue.
Adipocyte
Adiponectin
Gas6
Journal
Journal of diabetes investigation
ISSN: 2040-1124
Titre abrégé: J Diabetes Investig
Pays: Japan
ID NLM: 101520702
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
revised:
30
07
2020
received:
17
10
2019
accepted:
13
09
2020
pubmed:
25
9
2020
medline:
1
2
2022
entrez:
24
9
2020
Statut:
ppublish
Résumé
Obesity is characterized by disturbed adipocytokine expression and insulin resistance in adipocytes. Growth arrest-specific 6 (GAS6) is a gene encoding the Gas6 protein, which is expressed in fibroblasts, and its related signaling might be associated with adipose tissue inflammation, glucose intolerance and insulin resistance. The aim of this study was to investigate the associations among Gas6, adipocytokines and insulin resistance in adipocytes. Mature Simpson Golabi Behmel Syndrome adipocytes were treated with high levels of insulin to mimic insulin resistance, and were examined for the expressions of Gas6, cytokines and adipocytokines from preadipocytes in differentiation. In an animal study, high-fat diet-induced obese mice were used to verify the Gas6 expression in vitro. During the differentiation of adipocytes, the expression of Gas6 gradually decreased, and was obviously downregulated with adipocyte inflammation and insulin resistance. Gas6 levels were found to be in proportion to the expression of adiponectin, which has been regarded as closely relevant to improved insulin sensitivity after metformin treatment. Similar results were also confirmed in the animal study. Our results suggest that Gas6 might modulate the expression of adiponectin, and might therefore be associated with insulin resistance in adipose tissues.
Identifiants
pubmed: 32969596
doi: 10.1111/jdi.13412
pmc: PMC8015836
doi:
Substances chimiques
Adiponectin
0
Hypoglycemic Agents
0
Intercellular Signaling Peptides and Proteins
0
growth arrest-specific protein 6
0
Metformin
9100L32L2N
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
485-492Subventions
Organisme : Tri-Service General Hospital
ID : TSGH-C105-005-S03
Organisme : Tri-Service General Hospital
ID : TSGH-C107-006-006-S02
Organisme : Tri-Service General Hospital
ID : TSGH-C108-005-006-006-S02
Organisme : Tri-Service General Hospital
ID : TSGH-C107-103
Organisme : Tri-Service General Hospital
ID : TSGH-C108-143
Organisme : Tri-Service General Hospital
ID : MAB-107-063
Organisme : Tri-Service General Hospital
ID : MAB-108-045
Organisme : Tri-Service General Hospital
ID : MAB-106-113
Organisme : Tri-Service General Hospital
ID : MAB-108-046
Organisme : Ministry of Science and Technology
ID : MOST 107-2314-B-016-007
Organisme : Ministry of Science and Technology
ID : MOST 105-2314-B-016-040-MY3
Organisme : Ministry of Science and Technology
ID : MOST 108-2314-B-016-033-MY2
Organisme : Ministry of Science and Technology
ID : MOST 108-2314-B-016-019-MY3
Organisme : Ministry of Science and Technology
ID : MOST 108-2314-B-016-013
Informations de copyright
© 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
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