Age-related DNA methylation in paired normal and tumour breast tissue in Chinese breast cancer patients.
Aging
Breast cancer
DNA methylation
Journal
Epigenetics
ISSN: 1559-2308
Titre abrégé: Epigenetics
Pays: United States
ID NLM: 101265293
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
pubmed:
25
9
2020
medline:
13
1
2022
entrez:
24
9
2020
Statut:
ppublish
Résumé
Age-related DNA methylation is a potential mechanism contributing to breast cancer development. Studies of primarily Caucasian women have identified many CpG sites of age-related methylation in non-diseased breast tissue possibly driving cancer development over time. There is a paucity of studies involving Asian women whose ages at breast cancer onset are usually younger than Caucasians. We identified the 181 most consistent age-related methylation events in non-diseased breast tissue across published studies. Age-related methylation events were measured in adjacent normal and breast tumour tissue in an exclusively Asian population at the previously identified age-related methylation sites. Age-related methylation was found in 118 probes in adjacent normal breast tissue. Methylation of 99% of these sites was increased with age and predominantly located on CpG islands in promoter regions. To ascertain biological relevance to breast cancer, we focused on the 37 sites with overall higher methylation in tumour compared to adjacent normal samples. Some sites positively related to age, including
Identifiants
pubmed: 32970968
doi: 10.1080/15592294.2020.1819661
pmc: PMC8143246
doi:
Substances chimiques
GPC5 protein, human
0
Glypicans
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
677-691Références
Breast Cancer Res. 2017 Mar 17;19(1):31
pubmed: 28302140
Aging (Albany NY). 2018 Apr 18;10(4):573-591
pubmed: 29676998
Mol Cell. 2013 Jan 24;49(2):359-367
pubmed: 23177740
Nature. 2012 Oct 4;490(7418):61-70
pubmed: 23000897
CA Cancer J Clin. 2019 Jan;69(1):7-34
pubmed: 30620402
J Natl Cancer Inst. 2014 Dec 04;107(1):357
pubmed: 25479802
Cancer Lett. 2013 Dec 1;341(2):265-73
pubmed: 23962560
Cancer. 2008 Jan 1;112(1):43-9
pubmed: 17999418
Clin Epigenetics. 2015 Sep 16;7:100
pubmed: 26380585
Clin Epigenetics. 2018 Aug 29;10(1):112
pubmed: 30157950
PLoS One. 2011 Jan 18;6(1):e14524
pubmed: 21267076
J Natl Cancer Inst. 2015 Apr 13;107(7):
pubmed: 25868578
Nat Rev Genet. 2018 Jun;19(6):371-384
pubmed: 29643443
Cell Cycle. 2017 Feb 16;16(4):312-318
pubmed: 28055379
Oncotarget. 2017 Nov 29;8(70):114648-114662
pubmed: 29383109
Oncology. 2017;92(3):153-160
pubmed: 27978515
Oncotarget. 2012 Apr;3(4):462-74
pubmed: 22577155
Nat Genet. 2012 Nov;44(11):1236-42
pubmed: 23064414
Oncogene. 2011 Mar 24;30(12):1390-401
pubmed: 21132003
Epigenetics. 2015;10(12):1177-87
pubmed: 26680018
Oncotarget. 2016 Jan 12;7(2):1741-53
pubmed: 26646320
Genes Cancer. 2019;10(5-6):134-149
pubmed: 31798766
Leukemia. 2019 Apr;33(4):945-956
pubmed: 30470836
Int J Epidemiol. 2019 Oct 1;48(5):1536-1544
pubmed: 30879037
J Cell Mol Med. 2010 Jun;14(6B):1468-75
pubmed: 19799643
Mol Cell Endocrinol. 2008 May 14;286(1-2):230-7
pubmed: 18359151
Ann Surg Oncol. 2014 Feb;21(2):375-83
pubmed: 24114055
Breast Cancer Res. 2017 Jul 10;19(1):81
pubmed: 28693600
Gastroenterology. 2006 Sep;131(3):797-808
pubmed: 16952549
BMC Bioinformatics. 2011 Aug 04;12:323
pubmed: 21816040
Clin Cancer Res. 2006 Nov 15;12(22):6626-36
pubmed: 17121881
Cancer Res. 2016 Jun 15;76(12):3446-50
pubmed: 27256564
Epigenetics. 2014 Feb;9(2):268-75
pubmed: 24196486
Breast Cancer Res Treat. 2020 Apr;180(2):385-395
pubmed: 32043194
Oncogenesis. 2020 Jan 2;9(1):2
pubmed: 31900384
Genome Biol. 2018 Nov 6;19(1):187
pubmed: 30400938
Breast Cancer Res. 2013;15(4):R52
pubmed: 23820017
Dig Dis Sci. 2011 Jan;56(1):125-30
pubmed: 20927589
Genome Biol. 2014 Dec 03;15(12):503
pubmed: 25599564
Neoplasia. 2014 May;16(5):422-31
pubmed: 24863845
J Natl Cancer Inst. 2019 Oct 1;111(10):1051-1058
pubmed: 30794318
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Nat Commun. 2013;4:2612
pubmed: 24113773
Genome Biol. 2013;14(10):R115
pubmed: 24138928
Clin Epigenetics. 2020 Mar 12;12(1):45
pubmed: 32164769
Cell. 2018 Feb 22;172(5):979-992.e6
pubmed: 29456084