Additional considerations for studying brain metabolite levels across pain conditions using proton magnetic resonance spectroscopy.

Brain / diagnostic imaging Glutamic Acid Humans Pain Proton Magnetic Resonance Spectroscopy gamma-Aminobutyric Acid

Journal

NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515

Informations de publication

Date de publication:
01 01 2021
Historique:
received: 12 06 2020
revised: 17 09 2020
accepted: 17 09 2020
pubmed: 25 9 2020
medline: 22 1 2021
entrez: 24 9 2020
Statut: ppublish

Résumé

Advances in proton magnetic resonance spectroscopy (MRS) allow for the non-invasive examination of neuroinhibitory and neuroexcitatory processes in humans. In particular, these methods have been used to understand changes across chronic pain conditions. While a recent meta-analysis supports the idea that underlying brain metabolite levels may be unique to different pain conditions and may serve as biomarkers for specific pain conditions, the lack of consideration of differential brain aging processes across heterogenous pain conditions introduces a significant source of bias. Future studies need to address the interactions between pain and brain aging across different MRS metabolite measures.

Identifiants

DOI: 10.1016/j.neuroimage.2020.117392 PMID: 32971265
pubmed: 32971265
pii: S1053-8119(20)30877-6
doi: 10.1016/j.neuroimage.2020.117392
pii:
doi:

Substances chimiques

Glutamic Acid 3KX376GY7L
gamma-Aminobutyric Acid 56-12-2

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

117392

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2020. Published by Elsevier Inc.

Auteurs

Yenisel Cruz-Almeida (Y)

Pain Research & Intervention Center of Excellence, University of Florida, Gainesville, Florida; Department of Community Dentistry & Behavioral Science, College of Dentistry, University of Florida, PO BOX 112610, Gainesville, FL 326010, Florida; Center for Cognitive Aging and Memory, McKnight Brain Foundation, University of Florida, Gainesville, Florida; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida. Electronic address: cryeni@ufl.edu.

Eric Porges (E)

Center for Cognitive Aging and Memory, McKnight Brain Foundation, University of Florida, Gainesville, Florida; Department of Clinical & Health Psychology, College of Health Professions, University of Florida, Gainesville, Florida.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Additional considerations for studying brain...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide glutamique › Additional considerations for studying brain...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Additional considerations for studying brain...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Douleur › Additional considerations for studying brain...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Spectroscopie par résonance magnétique du proton › Additional considerations for studying brain...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › Additional considerations for studying brain...