The effect of different anaesthetics on echocardiographic evaluation of diastolic dysfunction in a heart failure with preserved ejection fraction model.
Anesthetics
/ administration & dosage
Animals
Diastole
/ drug effects
Echocardiography
Heart Failure
/ physiopathology
Heart Rate
/ drug effects
Isoflurane
/ administration & dosage
Ketamine
/ administration & dosage
Male
Obesity
/ physiopathology
Rats
Ventricular Dysfunction, Left
/ physiopathology
Xylazine
/ administration & dosage
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 09 2020
24 09 2020
Historique:
received:
26
03
2020
accepted:
03
09
2020
entrez:
25
9
2020
pubmed:
26
9
2020
medline:
19
12
2020
Statut:
epublish
Résumé
Heart failure with preserved ejection fraction (HFpEF) is currently untreated. Therapeutics development demands effective diagnosis of diastolic dysfunction in animal models mimicking human pathology, which requires appropriate anaesthetics. Here, we investigated which anaesthetic, ketamine/xylazine or isoflurane, could be used to reveal diastolic dysfunction in HFpEF-diseased obese ZSF1 rats by echocardiography. First, diastolic dysfunction was confirmed by pressure-volume loops in obese compared to lean control ZSF1 rats. In echocardiography, ketamine/xylazine, unlike isoflurane, was able to demonstrate impaired relaxation in obese ZSF1 rats, as reflected by impaired early (E) and late (A) filling peak velocities, decreased E/A ratio, and a prolonged deceleration and isovolumic relaxation time. Interestingly, ketamine/xylazine induced a wider separation of both tissue and pulsed wave Doppler-derived echocardiographic waves required for diastolic dysfunction diagnosis, potentially by reducing the heart rate (HR), while isoflurane resulted in merged waves. To assess whether HR-lowering alone explained the differences between the anaesthetics, echocardiography measurements under isoflurane with and without the HR-lowering drug ivabradine were compared. However, diastolic dysfunction could not be diagnosed in ivabradine-treated obese ZSF1 rats. In summary, ketamine/xylazine compared to isoflurane is the anaesthetic of choice to detect diastolic dysfunction by echocardiography in rodent HFpEF, which was only partly mediated by HR-lowering.
Identifiants
pubmed: 32973263
doi: 10.1038/s41598-020-72924-5
pii: 10.1038/s41598-020-72924-5
pmc: PMC7518268
doi:
Substances chimiques
Anesthetics
0
Xylazine
2KFG9TP5V8
Ketamine
690G0D6V8H
Isoflurane
CYS9AKD70P
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15701Références
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