Gastrointestinal Digestion of Food Proteins under the Effects of Released Bioactive Peptides on Digestive Health.


Journal

Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818

Informations de publication

Date de publication:
11 2020
Historique:
received: 24 04 2020
revised: 15 09 2020
pubmed: 26 9 2020
medline: 17 8 2021
entrez: 25 9 2020
Statut: ppublish

Résumé

The gastrointestinal tract represents a specialized interface between the organism and the external environment. Because of its direct contact with lumen substances, the modulation of digestive functions by dietary substances is supported by a growing body of evidence. Food-derived bioactive peptides have demonstrated a plethora of activities in the organism with increasing interest toward their impact over the digestive system and related physiological effects. This review updates the biological effects of food proteins, specifically milk and soybean proteins, associated to gastrointestinal health and highlights the study of digestion products and released peptides, the identification of the active form/s, and the evaluation of the mechanisms of action underlying their relationship with the digestive cells and receptors. The approach toward the modifications that food proteins and peptides undergo during gastrointestinal digestion and their bioavailability is a crucial step for current investigations on the field. The recent literature on the regulation of digestive functions by peptides has been mostly considered in terms of their influence on gastrointestinal motility and signaling, oxidative damage and inflammation, and malignant cellular proliferation. A final section regarding the actual challenges and future perspectives in this scientific topic is critically discussed.

Identifiants

pubmed: 32974997
doi: 10.1002/mnfr.202000401
doi:

Substances chimiques

Anticarcinogenic Agents 0
Dietary Proteins 0
Milk Proteins 0
Peptides 0
Receptors, Opioid 0
Soybean Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2000401

Informations de copyright

© 2020 Wiley-VCH GmbH.

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Auteurs

Samuel Fernández-Tomé (S)

Samuel Fernández-Tomé. Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria Princesa (IIS-IP), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Diego de León, 62, 28006, Madrid, Spain.

Blanca Hernández-Ledesma (B)

Blanca Hernández-Ledesma. Instituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM, CEI UAM+CSIC), Nicolás Cabrera, 9, 28049, Madrid, Spain.

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Classifications MeSH