The Self-Organizing Genome: Principles of Genome Architecture and Function.
chromatin
dynamics
gene expression
genome organization
nuclear architecture
phase separation
self-organization
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
01 10 2020
01 10 2020
Historique:
received:
10
05
2020
revised:
03
08
2020
accepted:
02
09
2020
pubmed:
26
9
2020
medline:
18
5
2021
entrez:
25
9
2020
Statut:
ppublish
Résumé
Genomes have complex three-dimensional architectures. The recent convergence of genetic, biochemical, biophysical, and cell biological methods has uncovered several fundamental principles of genome organization. They highlight that genome function is a major driver of genome architecture and that structural features of chromatin act as modulators, rather than binary determinants, of genome activity. The interplay of these principles in the context of self-organization can account for the emergence of structural chromatin features, the diversity and single-cell heterogeneity of nuclear architecture in cell types and tissues, and explains evolutionarily conserved functional features of genomes, including plasticity and robustness.
Identifiants
pubmed: 32976797
pii: S0092-8674(20)31155-7
doi: 10.1016/j.cell.2020.09.014
pmc: PMC7541718
mid: NIHMS1628495
pii:
doi:
Substances chimiques
Chromatin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
28-45Subventions
Organisme : Intramural NIH HHS
ID : Z01 BC010309
Pays : United States
Informations de copyright
Published by Elsevier Inc.
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