Tom Misteli

Affiliations

Cell Biology of Genomes Group, National Cancer Institute, National Institutes of Health, 41 Library Drive, Bethesda, MD 20892, USA. Electronic address: mistelit@mail.nih.gov.

Publications (41)

Single molecule analysis of lamin dynamics.

Methods (San Diego, Calif.)

Avec: Leonid A Serebryannyy , David A Ball , Tatiana S Karpova , Tom Misteli

High-Throughput RNA-HCR-FISH Detection of Endogenous Pre-mRNA Splice Variants.

Methods in molecular biology (Clifton, N.J.)

Avec: Asaf Shilo , Gianluca Pegoraro , Tom Misteli

A Scalable Random Access Micro-traps Array for Formation, Selective Retrieval and Capturing of Individual Droplets.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Avec: H Babahosseini , S Padmanabhan , T Misteli , D L DeVoe

Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells.

EMBO molecular medicine

Avec: Magda R Hamczyk , Ricardo Villa-Bellosta , Víctor Quesada , Pilar Gonzalo , Sandra Vidak , Rosa M Nevado , María J Andrés-Manzano , Tom Misteli , Carlos López-Otín , Vicente Andrés

Microfluidic on-demand droplet generation, storage, retrieval, and merging for single-cell pairing.

Lab on a chip

Avec: Hesam Babahosseini , Tom Misteli , Don L DeVoe

The stochastic nature of genome organization and function.

Current opinion in genetics & development

Avec: Varun Sood , Tom Misteli

Deterministic assembly of chromosome ensembles in a programmable membrane trap array.

Biofabrication

Avec: Hesam Babahosseini , Darawalee Wangsa , Mani Pabba , Thomas Ried , Tom Misteli , Don L DeVoe

Nuclear position modulates long-range chromatin interactions.

PLoS genetics

Avec: Elizabeth H Finn , Tom Misteli

Mesoscale structure-function relationships in mitochondrial transcriptional condensates.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Marina Feric , Azadeh Sarfallah , Furqan Dar , Dmitry Temiakov , Rohit V Pappu , Tom Misteli

Computational methods for analysing multiscale 3D genome organization.

Nature reviews. Genetics

Avec: Yang Zhang , Lorenzo Boninsegna , Muyu Yang , Tom Misteli , Frank Alber , Jian Ma

High-throughput image processing software for the study of nuclear architecture and gene expression.

Scientific reports

Avec: Adib Keikhosravi , Faisal Almansour , Christopher H Bohrer , Nadezda A Fursova , Krishnendu Guin , Varun Sood , Tom Misteli , Daniel R Larson , Gianluca Pegoraro

Assessment of the Utility of Gene Positioning Biomarkers in the Stratification of Prostate Cancers.

Frontiers in genetics

Avec: Karen J Meaburn , Tom Misteli

Interplay of primary sequence, position and secondary RNA structure determines alternative splicing of LMNA in a pre-mature aging syndrome.

Nucleic acids research

Avec: Asaf Shilo , Frances Anne Tosto , Jason W Rausch , Stuart F J Le Grice , Tom Misteli

Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization.

Cell

Avec: Elizabeth H Finn , Gianluca Pegoraro , Hugo B Brandão , Anne-Laure Valton , Marlies E Oomen , Job Dekker , Leonid Mirny , Tom Misteli

HiPLA: High-throughput imaging proximity ligation assay.

Methods (San Diego, Calif.)

Avec: Leonid A Serebryannyy , Tom Misteli

A programmable microfluidic platform for multisample injection, discretization, and droplet manipulation.

Biomicrofluidics

Avec: Hesam Babahosseini , Supriya Padmanabhan , Tom Misteli , Don L DeVoe

Systematic screening identifies therapeutic antisense oligonucleotides for Hutchinson-Gilford progeria syndrome.

Nature medicine

Avec: Madaiah Puttaraju , Michaela Jackson , Stephanie Klein , Asaf Shilo , C Frank Bennett , Leslie Gordon , Frank Rigo , Tom Misteli

Self-assembly of multi-component mitochondrial nucleoids via phase separation.

The EMBO journal

Avec: Marina Feric , Tyler G Demarest , Jane Tian , Deborah L Croteau , Vilhelm A Bohr , Tom Misteli

Spatiotemporal higher-order chromatin landscape of human histone gene clusters at histone locus bodies during the cell cycle in breast cancer progression.

Gene

Avec: Prachi N Ghule , Joseph R Boyd , Fleur Kabala , Andrew J Fritz , Nicole A Bouffard , Cong Gao , Kathleen Bright , Jill Macfarlane , David J Seward , Gianluca Pegoraro , Tom Misteli , Jane B Lian , Seth Frietze , Janet L Stein , Andre J van Wijnen , Gary S Stein

Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2.

Cell reports

Avec: Sandra Vidak , Leonid A Serebryannyy , Gianluca Pegoraro , Tom Misteli

Phase separation in genome organization across evolution.

Trends in cell biology

Avec: Marina Feric , Tom Misteli

The Self-Organizing Genome: Principles of Genome Architecture and Function.

Cell

Avec: Tom Misteli

Impairment of nuclear F-actin formation and its relevance to cellular phenotypes in Hutchinson-Gilford progeria syndrome.

Nucleus (Austin, Tex.)

Avec: Yuto Takahashi , Shogo Hiratsuka , Nanako Machida , Daisuke Takahashi , Junpei Matsushita , Pavel Hozak , Tom Misteli , Kei Miyamoto , Masahiko Harata

A high-throughput DNA FISH protocol to visualize genome regions in human cells.

STAR protocols

Avec: Elizabeth H Finn , Tom Misteli

Function moves biomolecular condensates in phase space.

BioEssays : news and reviews in molecular, cellular and developmental biology

Avec: Marina Feric , Tom Misteli

Large-scale mapping of positional changes of hypoxia-responsive genes upon activation.

Molecular biology of the cell

Avec: Koh Nakayama , Sigal Shachar , Elizabeth H Finn , Hiroyuki Sato , Akihiro Hirakawa , Tom Misteli

Allele-level visualization of transcription and chromatin by high-throughput imaging.

Research square

Avec: Faisal Almansour , Adib Keikhosravi , Gianluca Pegoraro , Tom Misteli

High-Throughput DNA FISH (hiFISH).

Methods in molecular biology (Clifton, N.J.)

Avec: Elizabeth Finn , Tom Misteli , Gianluca Pegoraro

HiFENS: high-throughput FISH detection of endogenous pre-mRNA splicing isoforms.

Nucleic acids research

Avec: Asaf Shilo , Gianluca Pegoraro , Tom Misteli

The nucleoporin ELYS regulates nuclear size by controlling NPC number and nuclear import capacity.

EMBO reports

Avec: Predrag Jevtić , Andria C Schibler , Chase C Wesley , Gianluca Pegoraro , Tom Misteli , Daniel L Levy

Molecular basis and biological function of variability in spatial genome organization.

Science (New York, N.Y.)

Avec: Elizabeth H Finn , Tom Misteli

A Deep Learning Pipeline for Nucleus Segmentation.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Avec: George Zaki , Prabhakar R Gudla , Kyunghun Lee , Justin Kim , Laurent Ozbun , Sigal Shachar , Manasi Gadkari , Jing Sun , Iain D C Fraser , Luis M Franco , Tom Misteli , Gianluca Pegoraro

Farnesyltransferase inhibition in HGPS.

Cell

Avec: Tom Misteli

Visualizing Cancer.

Cancer cell

Avec: Matthew Krummel , Kenneth Hu , Elisabeth G E de Vries , Jacky G Goetz , Diana Passaro , Sriram Subramaniam , Tom Misteli , Melissa Skala , Jose Javier Bravo-Cordero , Julie L Sutcliffe

HiIDDD: a high-throughput imaging pipeline for the quantitative detection of DNA damage in primary human immune cells.

Scientific reports

Avec: Kelsey Gallant , Arsun Bektas , Mary Kaileh , Ana Lustig , Luigi Ferrucci , Gianluca Pegoraro , Tom Misteli

Identification of epigenetic modulators as determinants of nuclear size and shape.

eLife

Avec: Andria C Schibler , Predrag Jevtic , Gianluca Pegoraro , Daniel L Levy , Tom Misteli

HiTIPS: High-Throughput Image Processing Software for the Study of Nuclear Architecture and Gene Expression.

bioRxiv : the preprint server for biology

Avec: Adib Keikhosravi , Faisal Almansour , Christopher H Bohrer , Nadezda A Fursova , Krishnendu Guin , Varun Sood , Tom Misteli , Daniel R Larson , Gianluca Pegoraro

Allele-level visualization of transcription and chromatin by high-throughput imaging.

bioRxiv : the preprint server for biology

Avec: Faisal Almansour , Adib Keikhosravi , Gianluca Pegoraro , Tom Misteli

Identification of molecular determinants of gene-specific bursting patterns by high-throughput imaging screens.

bioRxiv : the preprint server for biology

Avec: Varun Sood , Ronald Holewinski , Thorkell Andresson , Daniel R Larson , Tom Misteli

Cell type- and transcription-independent spatial proximity between enhancers and promoters.

Molecular biology of the cell

Avec: Yasmine Mian , Li Wang , Adib Keikhosravi , Konnie Guo , Tom Misteli , H Efsun Arda , Elizabeth H Finn

Allele-level visualization of transcription and chromatin by high-throughput imaging.

Histochemistry and cell biology

Avec: Faisal Almansour , Adib Keikhosravi , Gianluca Pegoraro , Tom Misteli

Réseau de co-auteurs

Gianluca Pegoraro 15 collaborations

Elizabeth H Finn 6 collaborations

Adib Keikhosravi 6 collaborations

Faisal Almansour 5 collaborations

Asaf Shilo 4 collaborations

Varun Sood 4 collaborations

Marina Feric 4 collaborations

Leonid A Serebryannyy 3 collaborations

Hesam Babahosseini 3 collaborations

Don L DeVoe 3 collaborations

Daniel R Larson 3 collaborations

Sandra Vidak 2 collaborations

Christopher H Bohrer 2 collaborations

Nadezda A Fursova 2 collaborations

Krishnendu Guin 2 collaborations

Sigal Shachar 2 collaborations

Andria C Schibler 2 collaborations

Daniel L Levy 2 collaborations

David A Ball 1 collaboration

Tatiana S Karpova 1 collaboration

H Babahosseini 1 collaboration

S Padmanabhan 1 collaboration

T Misteli 1 collaboration

D L DeVoe 1 collaboration

Magda R Hamczyk 1 collaboration

Ricardo Villa-Bellosta 1 collaboration

Víctor Quesada 1 collaboration

Pilar Gonzalo 1 collaboration

Rosa M Nevado 1 collaboration

María J Andrés-Manzano 1 collaboration

Carlos López-Otín 1 collaboration

Vicente Andrés 1 collaboration

Darawalee Wangsa 1 collaboration

Mani Pabba 1 collaboration

Thomas Ried 1 collaboration

Azadeh Sarfallah 1 collaboration

Furqan Dar 1 collaboration

Dmitry Temiakov 1 collaboration

Rohit V Pappu 1 collaboration

Yang Zhang 1 collaboration

Lorenzo Boninsegna 1 collaboration

Muyu Yang 1 collaboration

Frank Alber 1 collaboration

Jian Ma 1 collaboration

Karen J Meaburn 1 collaboration

Frances Anne Tosto 1 collaboration

Jason W Rausch 1 collaboration

Stuart F J Le Grice 1 collaboration

Hugo B Brandão 1 collaboration

Anne-Laure Valton 1 collaboration

Marlies E Oomen 1 collaboration

Job Dekker 1 collaboration

Leonid Mirny 1 collaboration

Supriya Padmanabhan 1 collaboration

Madaiah Puttaraju 1 collaboration

Michaela Jackson 1 collaboration

Stephanie Klein 1 collaboration

C Frank Bennett 1 collaboration

Leslie Gordon 1 collaboration

Frank Rigo 1 collaboration

Tyler G Demarest 1 collaboration

Jane Tian 1 collaboration

Deborah L Croteau 1 collaboration

Vilhelm A Bohr 1 collaboration

Prachi N Ghule 1 collaboration

Joseph R Boyd 1 collaboration

Fleur Kabala 1 collaboration

Andrew J Fritz 1 collaboration

Nicole A Bouffard 1 collaboration

Cong Gao 1 collaboration

Kathleen Bright 1 collaboration

Jill Macfarlane 1 collaboration

David J Seward 1 collaboration

Jane B Lian 1 collaboration

Seth Frietze 1 collaboration

Janet L Stein 1 collaboration

Andre J van Wijnen 1 collaboration

Gary S Stein 1 collaboration

Yuto Takahashi 1 collaboration

Shogo Hiratsuka 1 collaboration

Nanako Machida 1 collaboration

Daisuke Takahashi 1 collaboration

Junpei Matsushita 1 collaboration

Pavel Hozak 1 collaboration

Kei Miyamoto 1 collaboration

Masahiko Harata 1 collaboration

Koh Nakayama 1 collaboration

Hiroyuki Sato 1 collaboration

Akihiro Hirakawa 1 collaboration

Elizabeth Finn 1 collaboration

Predrag Jevtić 1 collaboration

Chase C Wesley 1 collaboration

George Zaki 1 collaboration

Prabhakar R Gudla 1 collaboration

Kyunghun Lee 1 collaboration

Justin Kim 1 collaboration

Laurent Ozbun 1 collaboration

Manasi Gadkari 1 collaboration

Jing Sun 1 collaboration

Iain D C Fraser 1 collaboration

Luis M Franco 1 collaboration

Matthew Krummel 1 collaboration

Kenneth Hu 1 collaboration

Elisabeth G E de Vries 1 collaboration

Jacky G Goetz 1 collaboration

Diana Passaro 1 collaboration

Sriram Subramaniam 1 collaboration

Melissa Skala 1 collaboration

Jose Javier Bravo-Cordero 1 collaboration

Julie L Sutcliffe 1 collaboration

Kelsey Gallant 1 collaboration

Arsun Bektas 1 collaboration

Mary Kaileh 1 collaboration

Ana Lustig 1 collaboration

Luigi Ferrucci 1 collaboration

Predrag Jevtic 1 collaboration

Ronald Holewinski 1 collaboration

Thorkell Andresson 1 collaboration

Yasmine Mian 1 collaboration

Li Wang 1 collaboration

Konnie Guo 1 collaboration

H Efsun Arda 1 collaboration