Function moves biomolecular condensates in phase space.
biomolecular condensates
mitochondria
nucleoid
nucleolus
nucleus
phase separation
transcription
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
ISSN: 1521-1878
Titre abrégé: Bioessays
Pays: United States
ID NLM: 8510851
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
19
02
2022
received:
03
01
2022
accepted:
22
02
2022
pubmed:
5
3
2022
medline:
26
4
2022
entrez:
4
3
2022
Statut:
ppublish
Résumé
Phase separation underlies the formation of biomolecular condensates. We hypothesize the cellular processes that occur within condensates shape their structural features. We use the example of transcription to discuss structure-function relationships in condensates. Various types of transcriptional condensates have been reported across the evolutionary spectrum in the cell nucleus as well as in mitochondrial and bacterial nucleoids. In vitro and in vivo observations suggest that transcriptional activity of condensates influences their supramolecular structure, which in turn affects their function. Condensate organization thus becomes driven by differences in miscibility among the DNA and proteins of the transcription machinery and the RNA transcripts they generate. These considerations are in line with the notion that cellular processes shape the structural properties of condensates, leading to a dynamic, mutual interplay between structure and function in the cell.
Identifiants
pubmed: 35243657
doi: 10.1002/bies.202200001
pmc: PMC9277701
mid: NIHMS1819947
doi:
Substances chimiques
Proteins
0
RNA
63231-63-0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2200001Subventions
Organisme : Intramural NIH HHS
ID : ZIA BC010309
Pays : United States
Organisme : NCI NIH HHS
ID : 1-ZIA-BC010309
Pays : United States
Informations de copyright
© 2022 Wiley Periodicals LLC.
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