Molecular basis and biological function of variability in spatial genome organization.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
06 09 2019
06 09 2019
Historique:
accepted:
22
07
2019
received:
01
05
2019
entrez:
7
9
2019
pubmed:
7
9
2019
medline:
27
12
2019
Statut:
ppublish
Résumé
The complex three-dimensional organization of genomes in the cell nucleus arises from a wide range of architectural features including DNA loops, chromatin domains, and higher-order compartments. Although these features are universally present in most cell types and tissues, recent single-cell biochemistry and imaging approaches have demonstrated stochasticity in transcription and high variability of chromatin architecture in individual cells. We review the occurrence, mechanistic basis, and functional implications of stochasticity in genome organization. We summarize recent observations on cell- and allele-specific variability of genome architecture, discuss the nature of extrinsic and intrinsic sources of variability in genome organization, and highlight potential implications of structural heterogeneity for genome function.
Identifiants
pubmed: 31488662
pii: 365/6457/eaaw9498
doi: 10.1126/science.aaw9498
pmc: PMC7421438
mid: NIHMS1616833
pii:
doi:
Substances chimiques
Chromatin
0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : U54 DK107980
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 BC010309
Pays : United States
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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