Phase separation in genome organization across evolution.
biomolecular condensates
evolution
genome organization
phase separation
transcription
Journal
Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
31
12
2020
revised:
17
02
2021
accepted:
01
03
2021
pubmed:
28
3
2021
medline:
15
12
2021
entrez:
27
3
2021
Statut:
ppublish
Résumé
Phase separation is emerging as a paradigm to explain the self-assembly and organization of membraneless bodies in the cell. Recent advances show that this principle also extends to nucleoprotein complexes, including DNA-based structures. We discuss here recent observations on the role of phase separation in genome organization across the evolutionary spectrum from bacteria to mammals. These findings suggest that molecular interactions amongst DNA-binding proteins evolved to form a variety of biomolecular condensates with distinct material properties that affect genome organization and function. We suggest that phase separation contributes to genome organization across evolution and that the resulting phase behavior of genomes may underlie regulatory mechanisms and disease.
Identifiants
pubmed: 33771451
pii: S0962-8924(21)00047-7
doi: 10.1016/j.tcb.2021.03.001
pmc: PMC8286288
mid: NIHMS1680799
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
671-685Subventions
Organisme : NIGMS NIH HHS
ID : FI2 GM128585
Pays : United States
Organisme : NIDDK NIH HHS
ID : U54 DK107980
Pays : United States
Organisme : NHGRI NIH HHS
ID : UM1 HG011593
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA BC010309
Pays : United States
Informations de copyright
Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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