Advances on Bone Substitutes through 3D Bioprinting.
3D bioprinting
biocompatible materials
bioprinting
dentistry
hydrogels
orthopedics
regenerative medicine
tissue engineering
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Sep 2020
23 Sep 2020
Historique:
received:
31
07
2020
revised:
15
09
2020
accepted:
21
09
2020
entrez:
26
9
2020
pubmed:
27
9
2020
medline:
24
2
2021
Statut:
epublish
Résumé
Reconstruction of bony defects is challenging when conventional grafting methods are used because of their intrinsic limitations (biological cost and/or biological properties). Bone regeneration techniques are rapidly evolving since the introduction of three-dimensional (3D) bioprinting. Bone tissue engineering is a branch of regenerative medicine that aims to find new solutions to treat bone defects, which can be repaired by 3D printed living tissues. Its aim is to overcome the limitations of conventional treatment options by improving osteoinduction and osteoconduction. Several techniques of bone bioprinting have been developed: inkjet, extrusion, and light-based 3D printers are nowadays available. Bioinks, i.e., the printing materials, also presented an evolution over the years. It seems that these new technologies might be extremely promising for bone regeneration. The purpose of the present review is to give a comprehensive summary of the past, the present, and future developments of bone bioprinting and bioinks, focusing the attention on crucial aspects of bone bioprinting such as selecting cell sources and attaining a viable vascularization within the newly printed bone. The main bioprinters currently available on the market and their characteristics have been taken into consideration, as well.
Identifiants
pubmed: 32977633
pii: ijms21197012
doi: 10.3390/ijms21197012
pmc: PMC7582371
pii:
doi:
Substances chimiques
Bone Substitutes
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : L.232/2016
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