Sporadic pregnancy loss and recurrent miscarriage.

Abortion, Habitual / etiology Abortion, Spontaneous / prevention & control Abortion, Threatened / drug therapy Female Humans Pregnancy Progesterone Progestins / therapeutic use Vagina
Natural progesterone Pregnancy loss Recurrent miscarriage Spontaneous abortion Threatened miscarriage Vaginal bleeding

Journal

Best practice & research. Clinical obstetrics & gynaecology
ISSN: 1532-1932
Titre abrégé: Best Pract Res Clin Obstet Gynaecol
Pays: Netherlands
ID NLM: 101121582

Informations de publication

Date de publication:
Nov 2020
Historique:
received: 09 07 2020
revised: 16 08 2020
accepted: 01 09 2020
pubmed: 27 9 2020
medline: 25 11 2020
entrez: 26 9 2020
Statut: ppublish

Résumé

Progesterone is essential for the maintenance of pregnancy, and progesterone deficiency is associated with miscarriage. The subject of whether progesterone supplementation in early pregnancy can prevent miscarriage has been a long-standing research question and has been investigated and debated in the medical literature for over 70 years. During this time, several different progestogens have been synthesised and tested for the prevention of miscarriage. In this chapter, we describe the prior evidence alongside the latest research using micronized natural progesterone as well as synthetic progestogens, which were used to treat both recurrent and threatened miscarriage. The totality of evidence indicates that women with a past history of miscarriage who present with bleeding in early pregnancy may benefit from the use of vaginal micronized progesterone. The clinical implications of the findings are discussed.

Identifiants

DOI: 10.1016/j.bpobgyn.2020.09.002 PMID: 32978069
pubmed: 32978069
pii: S1521-6934(20)30141-3
doi: 10.1016/j.bpobgyn.2020.09.002
pii:
doi:

Substances chimiques

Progestins 0
Progesterone 4G7DS2Q64Y

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

30-39

Informations de copyright

Copyright © 2020. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of competing interest There are no conflicts of interest to report.

Auteurs

Adam J Devall (AJ)

Tommy's National Centre for Miscarriage Research, College of Medical and Dental Sciences, University of Birmingham, UK.

Arri Coomarasamy (A)

Tommy's National Centre for Miscarriage Research, College of Medical and Dental Sciences, University of Birmingham, UK. Electronic address: a.coomarasamy@bham.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Avortements à répétition › Sporadic pregnancy loss and recurrent miscarriage.
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Issue de la grossesse › Avortement spontané › Sporadic pregnancy loss and recurrent miscarriage.
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Menace d'avortement › Sporadic pregnancy loss and recurrent miscarriage.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sporadic pregnancy loss and recurrent miscarriage.
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Sporadic pregnancy loss and recurrent miscarriage.
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la progestérone › Progestérone › Sporadic pregnancy loss and recurrent miscarriage.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Progestines › Sporadic pregnancy loss and recurrent miscarriage.
questionsmedicales.fr › Appareil urogénital › Système génital › Système génital de la femme › Vagin › Sporadic pregnancy loss and recurrent miscarriage.