Low oxygen tension differentially regulates the expression of placental solute carriers and ABC transporters.
ABC transporters
breast cancer resistance protein
hypoxia
multidrug resistance-associated proteins
placenta
solute carrier transporters
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
revised:
27
07
2020
received:
25
05
2020
accepted:
03
09
2020
pubmed:
27
9
2020
medline:
21
7
2021
entrez:
26
9
2020
Statut:
ppublish
Résumé
Low oxygen concentration, or hypoxia, is an important physiological regulator of placental function including chemical disposition. Here, we compared the ability of low oxygen tension to alter the expression of solute carriers (SLC) and ABC transporters in two human placental models, namely BeWo cells and term placental explants. We found that exposure to low oxygen concentration differentially regulates transporter expression in BeWo cells, including downregulation of ENT1, OATP4A1, OCTN2, BCRP, and MRP2/3/5, and upregulation of CNT1, OAT4, OATP2B1, SERT, SOAT, and MRP1. Similar upregulation of MRP1 and downregulation of MRP5 and BCRP were observed in explants, whereas uptake transporters were decreased or unchanged. Furthermore, a screening of transcriptional regulators of transporters revealed that hypoxia leads to a decrease in the mRNA levels of aryl hydrocarbon receptor, nuclear factor erythroid 2-related factor 2, and retinoid x receptor alpha in both human placental models. These data suggest that transporter expression is differentially regulated by oxygen concentration across experimental human placental models.
Identifiants
pubmed: 32978975
doi: 10.1002/1873-3468.13937
pmc: PMC7987846
mid: NIHMS1631598
doi:
Substances chimiques
ATP-Binding Cassette Transporters
0
Pregnancy Proteins
0
Solute Carrier Proteins
0
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
811-827Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES020522
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES007148
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES005022
Pays : United States
Organisme : NIEHS NIH HHS
ID : F31 ES029794
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003017
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029275
Pays : United States
Informations de copyright
© 2020 Federation of European Biochemical Societies.
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