Lauren M Aleksunes

Affiliations

Department of Pharmacology and Toxicology, Rutgers University, 170 Frelinghuysen Rd, Piscataway, NJ, 08854, USA; Center for Lipid Research, New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, NJ, 08901, USA; Department of Environmental and Occupational Health, School of Public Health, Rutgers University, 170 Frelinghuysen Rd, Piscataway, NJ, 08854, USA. Electronic address: aleksunes@eohsi.rutgers.edu.

Publications (43)

Anandamide down-regulates placental transporter expression through CB2 receptor-mediated inhibition of cAMP synthesis.

Pharmacological research

Avec: John T Szilagyi , Gabriella M Composto-Wahler , Laurie B Joseph , Bingbing Wang , Todd Rosen , Jeffrey D Laskin , Lauren M Aleksunes

Regulation of Placental Efflux Transporters during Pregnancy Complications.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Danielle Kozlosky , Emily Barrett , Lauren M Aleksunes

Associations between mycoestrogen exposure and sex steroid hormone concentrations in maternal serum and cord blood in the UPSIDE pregnancy cohort.

International journal of hygiene and environmental health

Avec: Carolyn W Kinkade , Lauren M Aleksunes , Anita Brinker , Brian Buckley , Jessica Brunner , Christina Wang , Richard K Miller , Thomas G O'Connor , Zorimar Rivera-Núñez , Emily S Barrett

Protective role of the placental efflux transporter BCRP/ABCG2 in the relationship between prenatal cadmium exposure, placenta weight, and size at birth.

Environmental research

Avec: Emily S Barrett , Zorimar Rivera-Núñez , Kylie Getz , Pamela Ohman-Strickland , Ranran Zhang , Danielle Kozlosky , Cathleen L Doherty , Brian T Buckley , Jessica Brunner , Richard K Miller , Thomas G O'Connor , Lauren M Aleksunes

Optimized extraction and analysis methods using liquid chromatography-tandem mass spectrometry for zearalenone and metabolites in human placental tissue.

Heliyon

Avec: Abigail Lazofsky , Anita Brinker , Ruby Gupta , Emily Barrett , Lauren M Aleksunes , Zorimar Rivera-Núñez , Brian Buckley

Advancing computer-aided drug discovery (CADD) by big data and data-driven machine learning modeling.

Drug discovery today

Avec: Linlin Zhao , Heather L Ciallella , Lauren M Aleksunes , Hao Zhu

Mechanism-Driven Read-Across of Chemical Hepatotoxicants Based on Chemical Structures and Biological Data.

Toxicological sciences : an official journal of the Society of Toxicology

Avec: Linlin Zhao , Daniel P Russo , Wenyi Wang , Lauren M Aleksunes , Hao Zhu

Brain region-specific regulation of histone acetylation and efflux transporters in mice.

Journal of biochemical and molecular toxicology

Avec: Dahea You , Hye Min Shin , Fatimah Mosaad , Jason R Richardson , Lauren M Aleksunes

Low oxygen tension differentially regulates the expression of placental solute carriers and ABC transporters.

FEBS letters

Avec: Ludwik Gorczyca , Jianyao Du , Kristin M Bircsak , Xia Wen , Anna M Vetrano , Lauren M Aleksunes

Impact of Fusarium-Derived Mycoestrogens on Female Reproduction: A Systematic Review.

Toxins

Avec: Carolyn W Kinkade , Zorimar Rivera-Núñez , Ludwik Gorcyzca , Lauren M Aleksunes , Emily S Barrett

Renoprotective Effects of Melatonin against Vancomycin-Related Acute Kidney Injury in Hospitalized Patients: a Retrospective Cohort Study.

Antimicrobial agents and chemotherapy

Avec: Thomas S Hong , Kelsey Briscese , Marshall Yuan , Kiran Deshpande , Lauren M Aleksunes , Luigi Brunetti

Integrating Concentration-Dependent Toxicity Data and Toxicokinetics To Inform Hepatotoxicity Response Pathways.

Environmental science & technology

Avec: Daniel P Russo , Lauren M Aleksunes , Katy Goyak , Hua Qian , Hao Zhu

Engaging Students in Pharmacogenetics: Patient Case Studies Using the PharmGKB Website.

CourseSource

Avec: Andrea M Mosquera , Lauren M Aleksunes

Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Renato J Scialis , Lauren M Aleksunes , Iván L Csanaky , Curtis D Klaassen , José E Manautou

Hepatic carboxylesterases are differentially regulated in PPARα-null mice treated with perfluorooctanoic acid.

Toxicology

Avec: Xia Wen , Angela A Baker , Curtis D Klaassen , J Christopher Corton , Jason R Richardson , Lauren M Aleksunes

Nonanimal Models for Acute Toxicity Evaluations: Applying Data-Driven Profiling and Read-Across.

Environmental health perspectives

Avec: Daniel P Russo , Judy Strickland , Agnes L Karmaus , Wenyi Wang , Sunil Shende , Thomas Hartung , Lauren M Aleksunes , Hao Zhu

Increased MDR1 Transporter Expression in Human Brain Endothelial Cells Through Enhanced Histone Acetylation and Activation of Aryl Hydrocarbon Receptor Signaling.

Molecular neurobiology

Avec: Dahea You , Xia Wen , Ludwik Gorczyca , Ayeshia Morris , Jason R Richardson , Lauren M Aleksunes

Optimization of 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acids as inhibitors of Keap1-Nrf2 protein-protein interaction to suppress neuroinflammation.

Bioorganic & medicinal chemistry

Avec: Dhulfiqar Ali Abed , Sumi Lee , Xia Wen , Ahmed R Ali , Vaibhav Mangipudy , Lauren M Aleksunes , Longqin Hu

Data-Driven Quantitative Structure-Activity Relationship Modeling for Human Carcinogenicity by Chronic Oral Exposure.

Environmental science & technology

Avec: Elena Chung , Daniel P Russo , Heather L Ciallella , Yu-Tang Wang , Min Wu , Lauren M Aleksunes , Hao Zhu

Prenatal Cadmium Exposure and Maternal Sex Steroid Hormone Concentrations across Pregnancy.

Toxics

Avec: Zorimar Rivera-Núñez , Megan Hansel , Camila Capurro , Danielle Kozlosky , Christina Wang , Cathleen L Doherty , Brian Buckley , Pamela Ohman-Strickland , Richard K Miller , Thomas G O'Connor , Lauren M Aleksunes , Emily S Barrett

Gadolinium during human pregnancy following administration of gadolinium chelate before pregnancy.

Birth defects research

Avec: Rachel M Coyte , Thomas Darrah , John Olesik , Emily Barrett , Thomas G O'Connor , Jessica Brunner , Tanzy Love , Rogelio Perez-D'Gregorio , Henry Z Wang , Lauren M Aleksunes , Brian Buckley , Cathleen Doherty , Richard K Miller

Fetoplacental Disposition and Toxicity of Cadmium in Mice Lacking the Bcrp Transporter.

Toxicological sciences : an official journal of the Society of Toxicology

Avec: Danielle Kozlosky , Cathleen Doherty , Brian Buckley , Michael J Goedken , Richard K Miller , Dan Dongeun Huh , Emily S Barrett , Lauren M Aleksunes

Repurposing FDA-approved drugs to treat chemical weapon toxicities: Interactive case studies for trainees.

Pharmacology research & perspectives

Avec: Lauren M Aleksunes , Joshua P Gray , Jaclynn Meshanni , Jeffrey D Laskin , Debra L Laskin

Time-dependent changes in kidney injury biomarkers in patients receiving multiple cycles of cisplatin chemotherapy.

Toxicology reports

Avec: Blessy George , Xia Wen , Nickie Mercke , Madeleine Gomez , Cindy O'Bryant , Daniel W Bowles , Yichun Hu , Susan L Hogan , Melanie S Joy , Lauren M Aleksunes

Predictive modeling of estrogen receptor agonism, antagonism, and binding activities using machine- and deep-learning approaches.

Laboratory investigation; a journal of technical methods and pathology

Avec: Heather L Ciallella , Daniel P Russo , Lauren M Aleksunes , Fabian A Grimm , Hao Zhu

Epigenetic Regulation of Multidrug Resistance Protein 1 and Breast Cancer Resistance Protein Transporters by Histone Deacetylase Inhibition.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Dahea You , Jason R Richardson , Lauren M Aleksunes

Extravillous trophoblast migration and invasion: Impact of environmental chemicals and pharmaceuticals.

Reproductive toxicology (Elmsford, N.Y.)

Avec: Cassandra Meakin , Emily S Barrett , Lauren M Aleksunes

Revealing Adverse Outcome Pathways from Public High-Throughput Screening Data to Evaluate New Toxicants by a Knowledge-Based Deep Neural Network Approach.

Environmental science & technology

Avec: Heather L Ciallella , Daniel P Russo , Lauren M Aleksunes , Fabian A Grimm , Hao Zhu

Transporters and Toxicity: Insights From the International Transporter Consortium Workshop 4.

Clinical pharmacology and therapeutics

Avec: Michael J Hafey , Lauren M Aleksunes , Christy C Bridges , Kenneth R Brouwer , Huan-Chieh Chien , Elaine M Leslie , Shuiying Hu , Yang Li , Jinshan Shen , Alex Sparreboom , Jason Sprowl , Donald Tweedie , Yurong Lai

Mechanism-driven modeling of chemical hepatotoxicity using structural alerts and an in vitro screening assay.

Journal of hazardous materials

Avec: Xuelian Jia , Xia Wen , Daniel P Russo , Lauren M Aleksunes , Hao Zhu

Cadmium reduces growth of male fetuses by impairing development of the placental vasculature and reducing expression of nutrient transporters.

Toxicology and applied pharmacology

Avec: Danielle Kozlosky , Alexander Lu , Cathleen Doherty , Brian Buckley , Michael J Goedken , Richard K Miller , Emily S Barrett , Lauren M Aleksunes

Placental BCRP transporter reduces cadmium accumulation and toxicity in immortalized human trophoblasts.

Reproductive toxicology (Elmsford, N.Y.)

Avec: Ranran Zhang , Lauren Walker , Xia Wen , Cathleen Doherty , Ludwik Gorczyca , Brian Buckley , Emily S Barrett , Lauren M Aleksunes

Effects of Therapeutically Approved Individual Bile Acids on The Development of Metabolic Dysfunction-Associated Steatohepatitis a Low Bile Acid Mouse Model.

Toxicological sciences : an official journal of the Society of Toxicology

Avec: Rulaiha Taylor , Veronia Basaly , Bo Kong , Ill Yang , Anita M Brinker , Gina Capece , Anisha Bhattacharya , Zakiyah R Henry , Katherine Otersen , Zhenning Yang , Vik Meadows , Stephanie Mera , Laurie B Joseph , Peihong Zhou , Lauren M Aleksunes , Troy Roepke , Brian Buckley , Grace L Guo

Fetal Exosomal Platelet-activating Factor Triggers Functional Progesterone Withdrawal in Human Placenta.

Reproductive sciences (Thousand Oaks, Calif.)

Avec: Kristy T Palomares , Nataliya Parobchak , Mayra Cruz Ithier , Lauren M Aleksunes , Paula M Castaño , Melody So , Revital Faro , Debra Heller , Bingbing Wang , Todd Rosen

Placental BCRP/ABCG2 Transporter Prevents Fetal Exposure to the Estrogenic Mycotoxin Zearalenone.

Toxicological sciences : an official journal of the Society of Toxicology

Avec: John T Szilagyi , Ludwik Gorczyca , Anita Brinker , Brian Buckley , Jeffrey D Laskin , Lauren M Aleksunes

BCRP/

Drug metabolism and disposition: the biological fate of chemicals

Avec: Xia Wen , Danielle Kozlosky , Ranran Zhang , Cathleen Doherty , Brian Buckley , Emily Barrett , Lauren M Aleksunes

Regulation of renal calbindin expression during cisplatin-induced kidney injury.

Journal of biochemical and molecular toxicology

Avec: Blessy George , John T Szilagyi , Melanie S Joy , Lauren M Aleksunes

In Vitro Inhibition of Renal OCT2 and MATE1 Secretion by Antiemetic Drugs.

International journal of molecular sciences

Avec: Blessy George , Xia Wen , Edgar A Jaimes , Melanie S Joy , Lauren M Aleksunes

High-throughput screening of toxicants that modulate extravillous trophoblast migration.

Toxicology letters

Avec: Cassandra Meakin , Christine Kim , Thomas Lampert , Lauren M Aleksunes

Evaluation of Cisplatin-Induced Acute Kidney Injury in Patients Co-Prescribed Serotonin Receptor Antagonists: A Retrospective Analysis.

Kidney360

Avec: Victoria Gutgarts , Supriya Gerardine , Roman A Shingarev , Andrea Knezevic , Emily C Zabor , Sheron Latcha , Melanie S Joy , Lauren M Aleksunes , Edgar A Jaimes

Determination of unbound platinum concentrations in human plasma using ultrafiltration and precipitation methods.

Journal of pharmacological and toxicological methods

Avec: Xia Wen , Cathleen Doherty , Lauren E Thompson , Christine Kim , Brian S Buckley , Edgar A Jaimes , Melanie S Joy , Lauren M Aleksunes

Hybrid non-animal modeling: A mechanistic approach to predict chemical hepatotoxicity.

Journal of hazardous materials

Avec: Elena Chung , Xia Wen , Xuelian Jia , Heather L Ciallella , Lauren M Aleksunes , Hao Zhu

Sociodemographic and dietary predictors of maternal and placental mycoestrogen concentrations in a US pregnancy cohort.

Journal of exposure science & environmental epidemiology

Avec: Carolyn W Kinkade , Anita Brinker , Brian Buckley , Olivia Waysack , I Diana Fernandez , Amber Kautz , Ying Meng , Huishan Shi , Jessica Brunner , Pamela Ohman-Strickland , Susan W Groth , Thomas G O'Connor , Lauren M Aleksunes , Emily S Barrett , Zorimar Rivera-Núñez

Réseau de co-auteurs

Brian Buckley 11 collaborations

Xia Wen 11 collaborations

Emily S Barrett 9 collaborations

Hao Zhu 9 collaborations

Daniel P Russo 7 collaborations

Danielle Kozlosky 6 collaborations

Richard K Miller 6 collaborations

Zorimar Rivera-Núñez 6 collaborations

Cathleen Doherty 6 collaborations

Thomas G O'Connor 5 collaborations

Heather L Ciallella 5 collaborations

Melanie S Joy 5 collaborations

Emily Barrett 4 collaborations

Anita Brinker 4 collaborations

Jessica Brunner 4 collaborations

Jason R Richardson 4 collaborations

Ludwik Gorczyca 4 collaborations

John T Szilagyi 3 collaborations

Jeffrey D Laskin 3 collaborations

Carolyn W Kinkade 3 collaborations

Pamela Ohman-Strickland 3 collaborations

Ranran Zhang 3 collaborations

Dahea You 3 collaborations

Blessy George 3 collaborations

Edgar A Jaimes 3 collaborations

Laurie B Joseph 2 collaborations

Bingbing Wang 2 collaborations

Todd Rosen 2 collaborations

Christina Wang 2 collaborations

Cathleen L Doherty 2 collaborations

Linlin Zhao 2 collaborations

Wenyi Wang 2 collaborations

Curtis D Klaassen 2 collaborations

Elena Chung 2 collaborations

Michael J Goedken 2 collaborations

Fabian A Grimm 2 collaborations

Cassandra Meakin 2 collaborations

Xuelian Jia 2 collaborations

Christine Kim 2 collaborations

Gabriella M Composto-Wahler 1 collaboration

Kylie Getz 1 collaboration

Brian T Buckley 1 collaboration

Abigail Lazofsky 1 collaboration

Ruby Gupta 1 collaboration

Hye Min Shin 1 collaboration

Fatimah Mosaad 1 collaboration

Jianyao Du 1 collaboration

Kristin M Bircsak 1 collaboration

Anna M Vetrano 1 collaboration

Ludwik Gorcyzca 1 collaboration

Thomas S Hong 1 collaboration

Kelsey Briscese 1 collaboration

Marshall Yuan 1 collaboration

Kiran Deshpande 1 collaboration

Luigi Brunetti 1 collaboration

Katy Goyak 1 collaboration

Hua Qian 1 collaboration

Andrea M Mosquera 1 collaboration

Renato J Scialis 1 collaboration

Iván L Csanaky 1 collaboration

José E Manautou 1 collaboration

Angela A Baker 1 collaboration

J Christopher Corton 1 collaboration

Judy Strickland 1 collaboration

Agnes L Karmaus 1 collaboration

Sunil Shende 1 collaboration

Thomas Hartung 1 collaboration

Ayeshia Morris 1 collaboration

Dhulfiqar Ali Abed 1 collaboration

Sumi Lee 1 collaboration

Ahmed R Ali 1 collaboration

Vaibhav Mangipudy 1 collaboration

Longqin Hu 1 collaboration

Yu-Tang Wang 1 collaboration

Min Wu 1 collaboration

Megan Hansel 1 collaboration

Camila Capurro 1 collaboration

Rachel M Coyte 1 collaboration

Thomas Darrah 1 collaboration

John Olesik 1 collaboration

Tanzy Love 1 collaboration

Rogelio Perez-D'Gregorio 1 collaboration

Henry Z Wang 1 collaboration

Dan Dongeun Huh 1 collaboration

Joshua P Gray 1 collaboration

Jaclynn Meshanni 1 collaboration

Debra L Laskin 1 collaboration

Nickie Mercke 1 collaboration

Madeleine Gomez 1 collaboration

Cindy O'Bryant 1 collaboration

Daniel W Bowles 1 collaboration

Yichun Hu 1 collaboration

Susan L Hogan 1 collaboration

Michael J Hafey 1 collaboration

Christy C Bridges 1 collaboration

Kenneth R Brouwer 1 collaboration

Huan-Chieh Chien 1 collaboration

Elaine M Leslie 1 collaboration

Shuiying Hu 1 collaboration

Yang Li 1 collaboration

Jinshan Shen 1 collaboration

Alex Sparreboom 1 collaboration

Jason Sprowl 1 collaboration

Donald Tweedie 1 collaboration

Yurong Lai 1 collaboration

Alexander Lu 1 collaboration

Lauren Walker 1 collaboration

Rulaiha Taylor 1 collaboration

Veronia Basaly 1 collaboration

Bo Kong 1 collaboration

Ill Yang 1 collaboration

Anita M Brinker 1 collaboration

Gina Capece 1 collaboration

Anisha Bhattacharya 1 collaboration

Zakiyah R Henry 1 collaboration

Katherine Otersen 1 collaboration

Zhenning Yang 1 collaboration

Vik Meadows 1 collaboration

Stephanie Mera 1 collaboration

Peihong Zhou 1 collaboration

Troy Roepke 1 collaboration

Grace L Guo 1 collaboration

Kristy T Palomares 1 collaboration

Nataliya Parobchak 1 collaboration

Mayra Cruz Ithier 1 collaboration

Paula M Castaño 1 collaboration

Melody So 1 collaboration

Revital Faro 1 collaboration

Debra Heller 1 collaboration

Thomas Lampert 1 collaboration

Victoria Gutgarts 1 collaboration

Supriya Gerardine 1 collaboration

Roman A Shingarev 1 collaboration

Andrea Knezevic 1 collaboration

Emily C Zabor 1 collaboration

Sheron Latcha 1 collaboration

Lauren E Thompson 1 collaboration

Brian S Buckley 1 collaboration

Olivia Waysack 1 collaboration

I Diana Fernandez 1 collaboration

Amber Kautz 1 collaboration

Ying Meng 1 collaboration

Huishan Shi 1 collaboration

Susan W Groth 1 collaboration