BCRP/

ATP Binding Cassette Transporter, Subfamily G, Member 2 / genetics Animals Apoptosis / drug effects Biological Transport, Active / genetics Cadmium / pharmacokinetics HEK293 Cells Humans Kidney / drug effects Mice Mice, Knockout Neoplasm Proteins / genetics Polymorphism, Single Nucleotide Protective Factors Renal Elimination / physiology

Journal

Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550

Informations de publication

Date de publication:
08 2021
Historique:
received: 07 03 2021
accepted: 03 05 2021
pubmed: 3 6 2021
medline: 24 3 2022
entrez: 2 6 2021
Statut: ppublish

Résumé

Exposure to the environmental pollutant cadmium is ubiquitous, as it is present in cigarette smoke and the food supply. Over time, cadmium enters and accumulates in the kidneys, where it causes tubular injury. The breast cancer resistance protein (BCRP, ATP-Binding Cassette G2

Identifiants

DOI: 10.1124/dmd.121.000446 PMID: 34074729 PMC: PMC8382159
pubmed: 34074729
pii: dmd.121.000446
doi: 10.1124/dmd.121.000446
pmc: PMC8382159
doi:

Substances chimiques

ABCG2 protein, human 0
ATP Binding Cassette Transporter, Subfamily G, Member 2 0
Abcg2 protein, mouse 0
Neoplasm Proteins 0
Cadmium 00BH33GNGH

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

629-637

Subventions

Organisme : NIEHS NIH HHS
ID : T32 ES007148
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES005022
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029275
Pays : United States
Organisme : NIEHS NIH HHS
ID : F31 ES032319
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003017
Pays : United States

Informations de copyright

Copyright © 2021 by The American Society for Pharmacology and Experimental Therapeutics.

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Auteurs

Xia Wen (X)

Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, New Jersey (X.W., D.K., L.M.A.); Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey (X.W., R.Z., C.D., B.B., E.B., L.M.A.); and Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey (R.Z., E.B.).

Danielle Kozlosky (D)

Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, New Jersey (X.W., D.K., L.M.A.); Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey (X.W., R.Z., C.D., B.B., E.B., L.M.A.); and Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey (R.Z., E.B.).

Ranran Zhang (R)

Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, New Jersey (X.W., D.K., L.M.A.); Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey (X.W., R.Z., C.D., B.B., E.B., L.M.A.); and Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey (R.Z., E.B.).

Cathleen Doherty (C)

Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, New Jersey (X.W., D.K., L.M.A.); Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey (X.W., R.Z., C.D., B.B., E.B., L.M.A.); and Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey (R.Z., E.B.).

Brian Buckley (B)

Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, New Jersey (X.W., D.K., L.M.A.); Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey (X.W., R.Z., C.D., B.B., E.B., L.M.A.); and Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey (R.Z., E.B.).

Emily Barrett (E)

Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, New Jersey (X.W., D.K., L.M.A.); Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey (X.W., R.Z., C.D., B.B., E.B., L.M.A.); and Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey (R.Z., E.B.).

Lauren M Aleksunes (LM)

Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, New Jersey (X.W., D.K., L.M.A.); Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey (X.W., R.Z., C.D., B.B., E.B., L.M.A.); and Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey (R.Z., E.B.) aleksunes@eohsi.rutgers.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs ABC › Sous-famille G des transporteurs à cassette liant l'ATP › Membre-2 de la sous-famille G des transporteurs à cassette liant l'ATP › BCRP/
questionsmedicales.fr › Eucaryotes › Animaux › BCRP/
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › BCRP/
questionsmedicales.fr › Métabolisme › Transport biologique › Transport biologique actif › BCRP/
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Cadmium › BCRP/
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › BCRP/
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › BCRP/
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › BCRP/
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › BCRP/
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › BCRP/
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › BCRP/
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › BCRP/
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de protection › BCRP/
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques des voies urinaires › Élimination rénale › BCRP/