Extravillous trophoblast migration and invasion: Impact of environmental chemicals and pharmaceuticals.
Extravillous trophoblast
Migration
Placenta
Placenta accreta spectrum
Preeclampsia
Pregnancy
Journal
Reproductive toxicology (Elmsford, N.Y.)
ISSN: 1873-1708
Titre abrégé: Reprod Toxicol
Pays: United States
ID NLM: 8803591
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
17
09
2021
revised:
09
11
2021
accepted:
22
11
2021
pubmed:
29
11
2021
medline:
15
3
2022
entrez:
28
11
2021
Statut:
ppublish
Résumé
During pregnancy, the migration and invasion of extravillous trophoblasts (EVTs) into the maternal uterus is essential for proper development of the placenta and fetus. During the first trimester, EVTs engraft and remodel maternal spiral arteries allowing for efficient blood flow and the transfer of essential nutrients and oxygen to the fetus. Aberrant migration of EVTs leading to either shallow or deep invasion into the uterus has been implicated in a number of gestational pathologies including preeclampsia, fetal growth restriction, and placenta accreta spectrum. The migration and invasion of EVTs is well-coordinated to ensure proper placentation. However, recent data point to the ability of xenobiotics to disrupt EVT migration. These xenobiotics include heavy metals, endocrine disrupting chemicals, and organic contaminants and have often been associated with adverse pregnancy outcomes. In most instances, xenobiotics appear to reduce EVT migration; however, there are select examples of enhanced motility after chemical exposure. In this review, we provide an overview of the 1) current experimental approaches used to evaluate EVT migration and invasion in vitro, 2) ability of environmental chemicals and pharmaceuticals to enhance or retard EVT motility, and 3) signaling pathways responsible for altered EVT migration that are sensitive to disruption by xenobiotics.
Identifiants
pubmed: 34838982
pii: S0890-6238(21)00175-1
doi: 10.1016/j.reprotox.2021.11.008
pmc: PMC8760155
mid: NIHMS1763945
pii:
doi:
Substances chimiques
Environmental Pollutants
0
Xenobiotics
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
60-68Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES005022
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029275
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES007148
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003017
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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