Regulation of Placental Efflux Transporters during Pregnancy Complications.
ATP Binding Cassette Transporter, Subfamily B, Member 1
/ metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 2
/ metabolism
ATP-Binding Cassette Transporters
/ metabolism
Female
Humans
Membrane Transport Proteins
/ metabolism
Multidrug Resistance-Associated Proteins
/ metabolism
Neoplasm Proteins
/ metabolism
Placenta
/ metabolism
Pregnancy
Pregnancy Complications
Xenobiotics
/ metabolism
Journal
Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
09
03
2021
accepted:
29
12
2021
pubmed:
8
1
2022
medline:
24
9
2022
entrez:
7
1
2022
Statut:
ppublish
Résumé
The placenta is essential for regulating the exchange of solutes between the maternal and fetal circulations. As a result, the placenta offers support and protection to the developing fetus by delivering crucial nutrients and removing waste and xenobiotics. ATP-binding cassette transporters, including multidrug resistance protein 1, multidrug resistance-associated proteins, and breast cancer resistance protein, remove chemicals through active efflux and are considered the primary transporters within the placental barrier. Altered transporter expression at the barrier could result in fetal exposure to chemicals and/or accumulation of xenobiotics within trophoblasts. Emerging data demonstrate that expression of these transporters is changed in women with pregnancy complications, suggesting potentially compromised integrity of placental barrier function. The purpose of this review is to summarize the regulation of placental efflux transporters during medical complications of pregnancy, including 1) placental inflammation/infection and chorioamnionitis, 2) hypertensive disorders of pregnancy, 3) metabolic disorders including gestational diabetes and obesity, and 4) fetal growth restriction/altered fetal size for gestational age. For each disorder, we review the basic pathophysiology and consider impacts on the expression and function of placental efflux transporters. Mechanisms of transporter dysregulation and implications for fetal drug and toxicant exposure are discussed. Understanding how transporters are up- or downregulated during pathology is important in assessing possible exposures of the fetus to potentially harmful chemicals in the environment as well as the disposition of novel therapeutics intended to treat placental and fetal diseases. SIGNIFICANCE STATEMENT: Diseases of pregnancy are associated with reduced expression of placental barrier transporters that may impact fetal pharmacotherapy and exposure to dietary and environmental toxicants.
Identifiants
pubmed: 34992073
pii: dmd.121.000449
doi: 10.1124/dmd.121.000449
pmc: PMC9513846
doi:
Substances chimiques
ATP Binding Cassette Transporter, Subfamily B, Member 1
0
ATP Binding Cassette Transporter, Subfamily G, Member 2
0
ATP-Binding Cassette Transporters
0
Membrane Transport Proteins
0
Multidrug Resistance-Associated Proteins
0
Neoplasm Proteins
0
Xenobiotics
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1364-1375Subventions
Organisme : NIEHS NIH HHS
ID : T32 ES007148
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES005022
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029275
Pays : United States
Organisme : NIEHS NIH HHS
ID : F31 ES032319
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003017
Pays : United States
Informations de copyright
Copyright © 2022 by The American Society for Pharmacology and Experimental Therapeutics.
Références
J Soc Gynecol Investig. 2004 Sep;11(6):342-52
pubmed: 15350246
N Engl J Med. 2005 Jun 16;352(24):2477-86
pubmed: 15951574
Placenta. 2008 Aug;29(8):743-7
pubmed: 18558430
Am J Obstet Gynecol. 2004 Jul;191(1):254-8
pubmed: 15295375
Am J Obstet Gynecol. 1996 May;174(5):1433-40
pubmed: 9065108
Pharmacogenet Genomics. 2011 Mar;21(3):152-61
pubmed: 20216335
Environ Toxicol Pharmacol. 2011 Nov;32(3):465-71
pubmed: 22004967
J Cell Mol Med. 2018 Nov;22(11):5378-5393
pubmed: 30256530
N Engl J Med. 2008 May 8;358(19):1991-2002
pubmed: 18463375
Can J Physiol Pharmacol. 2006 Dec;84(12):1251-8
pubmed: 17487233
Dev Biol. 2008 Feb 15;314(2):362-75
pubmed: 18199431
Mol Pharmacol. 2008 Mar;73(3):845-54
pubmed: 18042733
Int J Gynaecol Obstet. 2009 Mar;104 Suppl 1:S25-6
pubmed: 19150058
J Reprod Immunol. 2012 Jun;94(2):151-4
pubmed: 22542907
J Immunol. 2007 Jul 1;179(1):557-65
pubmed: 17579077
Drug Metab Dispos. 2007 Apr;35(4):595-601
pubmed: 17237156
Front Pharmacol. 2018 Sep 12;9:1027
pubmed: 30258364
Reprod Toxicol. 2020 Dec;98:82-91
pubmed: 32916274
Drug Metab Dispos. 2011 Jun;39(6):1000-7
pubmed: 21430233
Placenta. 1993 Jan-Feb;14(1):63-73
pubmed: 8456090
Clin Obstet Gynecol. 1999 Sep;42(3):532-50
pubmed: 10451769
PLoS One. 2012;7(4):e35027
pubmed: 22558111
J Clin Invest. 1996 Jan 15;97(2):540-50
pubmed: 8567979
Cancer Res. 1998 Dec 1;58(23):5337-9
pubmed: 9850061
Am J Obstet Gynecol. 2009 Jul;201(1):61.e1-7
pubmed: 19371858
Drug Metab Dispos. 2005 Apr;33(4):524-9
pubmed: 15640379
Placenta. 2017 Mar;51:57-63
pubmed: 28292469
Obstet Gynecol. 1999 Aug;94(2):267-73
pubmed: 10432141
J Clin Invest. 2018 Oct 1;128(10):4224-4235
pubmed: 30272581
Clin Chim Acta. 2017 Feb;465:53-71
pubmed: 27988319
J Pharmacol Exp Ther. 2005 Jan;312(1):44-52
pubmed: 15448171
Obstet Gynecol. 1996 Feb;87(2):163-8
pubmed: 8559516
Aust N Z J Obstet Gynaecol. 1996 Aug;36(3):286-90
pubmed: 8883752
J Cell Biochem. 2012 Jul;113(7):2383-96
pubmed: 22573555
Placenta. 2013 Jan;34(1):67-74
pubmed: 23122699
Placenta. 2006 Jun-Jul;27(6-7):699-706
pubmed: 16165208
Early Hum Dev. 2012 May;88 Suppl 2:S69-74
pubmed: 22633519
J Matern Fetal Neonatal Med. 2013 Sep;26(13):1332-6
pubmed: 23489073
J Perinat Med. 2015 Jan;43(1):19-36
pubmed: 25720095
Eur J Pharm Sci. 2017 May 1;102:94-102
pubmed: 28274777
Toxicol Appl Pharmacol. 2014 May 15;277(1):77-85
pubmed: 24631341
Endocrinology. 2007 Feb;148(2):559-65
pubmed: 17095594
IUBMB Life. 2010 May;62(5):315-33
pubmed: 20209635
PLoS One. 2015 Mar 23;10(3):e0121029
pubmed: 25799433
Reprod Toxicol. 2016 Jun;61:58-67
pubmed: 26965993
Inflamm Res. 2001 Jul;50(7):362-70
pubmed: 11506391
Am J Obstet Gynecol. 2000 Apr;182(4):938-42
pubmed: 10764477
Int Immunopharmacol. 2015 Jun;26(2):349-56
pubmed: 25912346
Arch Toxicol. 2020 Nov;94(11):3799-3817
pubmed: 32915249
Pharmacol Res. 2019 Mar;141:331-342
pubmed: 30610963
Front Pharmacol. 2014 Jun 24;5:149
pubmed: 25009498
J Cell Mol Med. 2020 Sep;24(18):10636-10647
pubmed: 32779889
Placenta. 2015 Oct;36(10):1138-47
pubmed: 26311557
Am J Obstet Gynecol. 2015 Oct;213(4 Suppl):S29-52
pubmed: 26428501
Respir Physiol Neurobiol. 2011 Aug 31;178(1):51-8
pubmed: 21621012
Diabetes Care. 2002 Oct;25(10):1862-8
pubmed: 12351492
Am J Obstet Gynecol. 2017 Aug;217(2):200.e1-200.e17
pubmed: 28347715
Toxicol Sci. 2013 Dec;136(2):382-91
pubmed: 24014645
J Cell Sci. 1999 Feb;112 ( Pt 3):415-22
pubmed: 9885294
Front Immunol. 2021 May 21;12:680246
pubmed: 34093581
Int J Dev Biol. 2010;54(2-3):341-54
pubmed: 19876834
Am J Obstet Gynecol. 1998 Jan;178(1 Pt 1):161-5
pubmed: 9465822
Am J Reprod Immunol. 2014 Apr;71(4):330-58
pubmed: 24417618
Placenta. 2010 Mar;31 Suppl:S60-5
pubmed: 20096455
Int J Dev Biol. 2010;54(2-3):377-90
pubmed: 19876836
J Matern Fetal Neonatal Med. 2015 Sep;28(13):1500-9
pubmed: 25184305
Diabetes Care. 2007 Jul;30 Suppl 2:S169-74
pubmed: 17596467
Placenta. 2003 Nov;24(10):951-8
pubmed: 14580377
Placenta. 1981 Oct-Dec;2(4):303-16
pubmed: 7301778
Endocrine. 2002 Oct;19(1):13-22
pubmed: 12583599
PLoS One. 2013 Jun 10;8(6):e65728
pubmed: 23762418
Diabetes Care. 2015 Jan;38 Suppl:S8-S16
pubmed: 25537714
Cells. 2019 Sep 26;8(10):
pubmed: 31561453
Pflugers Arch. 1986 Jan;406(1):60-4
pubmed: 3951969
Biochim Biophys Acta. 2015 Jan;1852(1):131-6
pubmed: 25446997
Exp Toxicol Pathol. 2006 Aug;58(1):39-47
pubmed: 16806864
J Pharmacol Toxicol Methods. 2006 Jul-Aug;54(1):78-89
pubmed: 16545584
J Obstet Gynaecol Can. 2013 Aug;35(8):741-748
pubmed: 24007710
Lancet. 2009 May 23;373(9677):1773-9
pubmed: 19465232
Am J Physiol Regul Integr Comp Physiol. 2000 Mar;278(3):R677-83
pubmed: 10712288
Toxicology. 2005 Aug 1;211(3):242-52
pubmed: 15869837
Drug Metab Dispos. 2005 Jul;33(7):896-904
pubmed: 15821043
Placenta. 2005 Feb-Mar;26(2-3):268-70
pubmed: 15708129
Obstet Gynecol. 2003 Jul;102(1):181-92
pubmed: 12850627
Drug Metab Dispos. 2014 Apr;42(4):603-10
pubmed: 24281836
Obstet Gynecol. 2009 May;113(5):1001-1007
pubmed: 19384114
Am J Pathol. 2015 Jun;185(6):1666-75
pubmed: 25963552
Chemosphere. 2022 Jan;287(Pt 3):132244
pubmed: 34537452
Int Immunopharmacol. 2001 Feb;1(2):189-99
pubmed: 11360920
Environ Toxicol. 2009 Feb;24(1):33-42
pubmed: 18442069
Pediatr Res. 1990 Oct;28(4):383-7
pubmed: 2235138
Pediatr Neonatol. 2013 Aug;54(4):267-74
pubmed: 23639744
Am J Obstet Gynecol. 2013 Apr;208(4):290.e1-6
pubmed: 23531326
Acta Pharmacol Sin. 2005 Nov;26(11):1387-94
pubmed: 16225763
Placenta. 2013 Mar;34 Suppl:S34-9
pubmed: 23153501
FASEB J. 2007 Nov;21(13):3592-605
pubmed: 17595345
Diabetologia. 2016 Jul;59(7):1403-1411
pubmed: 27073002
Semin Reprod Med. 2011 May;29(3):257-65
pubmed: 21769765
J Clin Hypertens (Greenwich). 2001 Mar-Apr;3(2):75-88
pubmed: 11416689
Am J Physiol Regul Integr Comp Physiol. 2005 Oct;289(4):R963-9
pubmed: 15961534
Acta Obstet Gynecol Scand. 2008;87(4):403-7
pubmed: 18382864
Adv Drug Deliv Rev. 2009 Jan 31;61(1):3-13
pubmed: 19135109
JAMA. 1997 Jul 16;278(3):207-11
pubmed: 9218666
J Biol Chem. 2003 May 16;278(20):17664-71
pubmed: 12637526
Drug Metab Dispos. 2018 May;46(5):619-627
pubmed: 29386232
N Engl J Med. 1988 Oct 13;319(15):972-8
pubmed: 3262199
Cancer Metastasis Rev. 2007 Mar;26(1):15-37
pubmed: 17295059
Pediatr Dev Pathol. 2003 Sep-Oct;6(5):435-48
pubmed: 14708737
Placenta. 2006 Nov-Dec;27(11-12):1096-102
pubmed: 16460798
Toxicology. 2016 Jan 18;340:34-42
pubmed: 26740192
Am J Physiol Endocrinol Metab. 2006 May;290(5):E798-807
pubmed: 16352672
Eur J Biochem. 1998 Aug 15;256(1):170-8
pubmed: 9746361
Placenta. 2000 Jan;21(1):14-22
pubmed: 10692246
Cell Calcium. 2005 Jan;37(1):1-8
pubmed: 15541458
Placenta. 2008 Jan;29(1):39-43
pubmed: 17923155
J Pediatr. 2019 May;208:81-88.e2
pubmed: 30732998
Best Pract Res Clin Obstet Gynaecol. 2011 Jun;25(3):273-85
pubmed: 21212025
Mol Pharmacol. 2008 Mar;73(3):949-59
pubmed: 18079276
Cytokine. 2014 Dec;70(2):134-40
pubmed: 25082648
Placenta. 2018 Sep;69:32-39
pubmed: 30213482
Drug Metab Dispos. 2015 Jul;43(7):951-7
pubmed: 25887454
AMA J Dis Child. 1960 Jun;99:714-21
pubmed: 13798887
Vaccine. 2003 Jul 28;21(24):3365-9
pubmed: 12850341
Semin Perinatol. 2008 Jun;32(3):161-5
pubmed: 18482615
Placenta. 2007 May-Jun;28(5-6):487-97
pubmed: 16860862
Am J Physiol Regul Integr Comp Physiol. 2000 Oct;279(4):R1495-503
pubmed: 11004020
Drug Metab Dispos. 2008 Sep;36(9):1944-50
pubmed: 18505788
Rom J Morphol Embryol. 2016;57(2):507-12
pubmed: 27516026
PLoS One. 2013 Jun 13;8(6):e65498
pubmed: 23785430
Clin Chim Acta. 2017 May;468:60-70
pubmed: 28213010
AAPS J. 2015 Jan;17(1):65-82
pubmed: 25236865
J Clin Invest. 2004 Sep;114(6):744-54
pubmed: 15372095
J Perinat Med. 2008;36(4):277-81
pubmed: 18598115
Am J Reprod Immunol. 2003 Jul;50(1):66-76
pubmed: 14506930
Hypertension. 2008 Apr;51(4):970-5
pubmed: 18259009
Am J Obstet Gynecol. 2011 Mar;204(3):193-201
pubmed: 21094932
Immunol Rev. 2000 Oct;177:195-203
pubmed: 11138776
AAPS J. 2020 Oct 25;22(6):138
pubmed: 33099683
Dtsch Arztebl Int. 2017 Jul 16;114(24):412-418
pubmed: 28669379
Front Endocrinol (Lausanne). 2020 Apr 15;11:205
pubmed: 32351451
J Perinatol. 2013 Jun;33(6):441-5
pubmed: 23238570
J Perinat Med. 2017 Oct 26;45(7):887-893
pubmed: 28675750
Placenta. 2005 Sep-Oct;26(8-9):672-7
pubmed: 16085046
J Reprod Immunol. 2003 Aug;59(2):245-51
pubmed: 12896826
N Engl J Med. 1998 Mar 12;338(11):701-5
pubmed: 9494145
J Clin Pharmacol. 2019 Sep;59 Suppl 1:S70-S81
pubmed: 31502693
JAMA. 2004 Nov 17;292(19):2357-65
pubmed: 15547163
Clin Chim Acta. 2015 Dec 7;451(Pt B):117-20
pubmed: 26525965
Front Immunol. 2019 Dec 10;10:2896
pubmed: 31921157
Am J Obstet Gynecol. 2010 Apr;202(4):383.e1-7
pubmed: 20350646
Placenta. 2010 Nov;31(11):951-7
pubmed: 20869770
Reprod Sci. 2014 Oct;21(10):1215-27
pubmed: 24840939
Obstet Gynecol. 2014 Jun;123(6):1177-1184
pubmed: 24807336
Clin Transl Sci. 2020 May;13(3):580-588
pubmed: 31917511
Am J Pathol. 2005 Jan;166(1):39-48
pubmed: 15631998
Eur J Clin Microbiol Infect Dis. 1997 Jun;16(6):417-23
pubmed: 9248744
Front Microbiol. 2021 Jul 30;12:706499
pubmed: 34394055
Dev Biol. 2014 Mar 15;387(2):131-41
pubmed: 24485853
Infect Dis Obstet Gynecol. 1997;5(4):273-9
pubmed: 18476151
J Nucl Med. 2005 Sep;46(9):1537-45
pubmed: 16157538
Am Heart J. 2019 Nov;217:84-93
pubmed: 31520898
Aust N Z J Obstet Gynaecol. 2000 May;40(2):133-8
pubmed: 10925899
Cell Physiol Biochem. 2018;45(2):591-604
pubmed: 29402780
Biochem Biophys Res Commun. 1997 Jun 27;235(3):849-53
pubmed: 9207250
Gene. 1988 Nov 30;71(2):401-11
pubmed: 2906314
J Reprod Dev. 2012;58(3):283-7
pubmed: 22790871
J Clin Invest. 2000 Mar;105(5):577-87
pubmed: 10712429
Lancet. 2001 Jan 20;357(9251):209-15
pubmed: 11213110
J Cell Mol Med. 2011 Oct;15(10):2164-75
pubmed: 21070600
Drug Metab Dispos. 2020 Sep;48(9):735-741
pubmed: 32591415
J Clin Invest. 1999 Nov;104(10):1441-7
pubmed: 10562306
Pathology. 2008 Jun;40(4):372-6
pubmed: 18446627
Am J Obstet Gynecol. 2008 Oct;199(4):375.e1-5
pubmed: 18928978
Toxicol Sci. 2019 Apr 1;168(2):394-404
pubmed: 30576553
Placenta. 2014 Feb;35 Suppl:S81-5
pubmed: 24220516
Obstet Gynecol. 1985 Nov;66(5):657-60
pubmed: 4058824
Biochim Biophys Acta Mol Basis Dis. 2020 Feb 1;1866(2):165359
pubmed: 30593896
Clin Chem. 2013 Sep;59(9):1310-21
pubmed: 23536513
Sci Rep. 2019 Aug 7;9(1):11488
pubmed: 31391498
Clin Pharmacol Ther. 2005 Aug;78(2):123-31
pubmed: 16084847
Drug Metab Dispos. 2011 Oct;39(10):1850-9
pubmed: 21742899
Drug Metab Dispos. 2010 Oct;38(10):1760-6
pubmed: 20610559
J Clin Invest. 2010 Apr;120(4):1016-25
pubmed: 20364099
F1000Prime Rep. 2015 Feb 03;7:14
pubmed: 25750732
BJOG. 2017 Jan;124(1):132-140
pubmed: 27297096
Hypertension. 2007 Mar;49(3):604-11
pubmed: 17261642
Int J Mol Sci. 2020 Mar 10;21(5):
pubmed: 32164226
Biochemistry. 2014 Feb 18;53(6):991-1000
pubmed: 24506763
J Biol Chem. 2000 Feb 11;275(6):4507-12
pubmed: 10660625
Diabetol Metab Syndr. 2011 Aug 10;3(1):19
pubmed: 21831283
Am J Reprod Immunol. 2011 Jun;65(6):549-56
pubmed: 21214658
Obstet Gynecol. 1973 Jul;42(1):112-7
pubmed: 4720190
Annu Rev Cell Dev Biol. 2015;31:523-52
pubmed: 26443191
J Perinatol. 2000 Jul-Aug;20(5):335-7
pubmed: 10920796
Biochem Pharmacol. 2018 Oct;156:467-478
pubmed: 30217571
Placenta. 2009 Mar;30 Suppl A:S43-8
pubmed: 19081132
J Biol Chem. 2000 Sep 29;275(39):30069-74
pubmed: 10893247
Int J Dev Biol. 2010;54(2-3):367-75
pubmed: 19876831
Biochem J. 2003 May 1;371(Pt 3):897-905
pubmed: 12568656
Placenta. 2006 Jun-Jul;27(6-7):602-9
pubmed: 16143395
Placenta. 2009 Jan;30(1):15-24
pubmed: 19027158