Placental BCRP transporter reduces cadmium accumulation and toxicity in immortalized human trophoblasts.
BCRP
BeWo
Cadmium
Efflux
Metal
Toxicity
Transporter
Journal
Reproductive toxicology (Elmsford, N.Y.)
ISSN: 1873-1708
Titre abrégé: Reprod Toxicol
Pays: United States
ID NLM: 8803591
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
14
07
2023
revised:
20
08
2023
accepted:
28
08
2023
pmc-release:
01
10
2024
pubmed:
4
9
2023
medline:
4
9
2023
entrez:
3
9
2023
Statut:
ppublish
Résumé
Cadmium (Cd) is a ubiquitous environmental metal detectable in most pregnant women. Animal and human studies demonstrate that in utero exposure to Cd reduces birth weight and impairs perinatal growth due to placental toxicity. BCRP is a prominent transporter that can efflux xenobiotics from the placenta. This study sought to investigate Cd transport and toxicity in cultured human BeWo trophoblasts with reduced expression and function of the placental barrier transporter BCRP. Knockdown (KD) of BCRP protein expression and function in BeWo trophoblasts increased the intracellular accumulation of Cd by 100% following treatment with 1 μM CdCl
Identifiants
pubmed: 37660740
pii: S0890-6238(23)00140-5
doi: 10.1016/j.reprotox.2023.108466
pmc: PMC10591833
mid: NIHMS1931945
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108466Subventions
Organisme : NIEHS NIH HHS
ID : T32 ES007148
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES005022
Pays : United States
Organisme : NIEHS NIH HHS
ID : F31 ES029794
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003017
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029275
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Lauren Aleksunes reports financial support was provided by National Institute of Environmental Health Sciences. Ludwik Gorczyca reports financial support was provided by National Institute of Environmental Health Sciences. Emily Barrett reports financial support was provided by National Institute of Environmental Health Sciences. Lauren Aleksunes reports financial support was provided by National Center for Advancing Translational Sciences.
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