C-Reactive Protein Causes Blood Pressure Drop in Rabbits and Induces Intracellular Calcium Signaling.
Animals
Biomarkers
Blood Pressure
/ drug effects
C-Reactive Protein
/ metabolism
Calcium
/ metabolism
Calcium Signaling
/ drug effects
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Epithelial Cells
/ drug effects
Female
Humans
Intracellular Space
/ metabolism
Rabbits
Sepsis
/ blood
Systemic Inflammatory Response Syndrome
/ blood
CRP
SIRS
adrenergic receptor
calcium signaling
calcium transient
cardiovascular system
eNOS
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
05
2020
accepted:
22
07
2020
entrez:
28
9
2020
pubmed:
29
9
2020
medline:
1
5
2021
Statut:
epublish
Résumé
Systemic diseases characterized by elevated levels of C-reactive protein (CRP), such as sepsis or systemic inflammatory response syndrome, are usually associated with hardly controllable haemodynamic instability. We therefore investigated whether CRP itself influences blood pressure and heart rate. Immediately after intravenous injection of purified human CRP (3.5 mg CRP/kg body weight) into anesthetized rabbits, blood pressure dropped critically in all animals, while control animals injected with bovine serum albumin showed no response. Heart rate did not change in either group. Approaching this impact on a cellular level, we investigated the effect of CRP in cell lines expressing adrenoceptors (CHO-α1A and DU-145). CRP caused a Ca
Identifiants
pubmed: 32983135
doi: 10.3389/fimmu.2020.01978
pmc: PMC7483553
doi:
Substances chimiques
Biomarkers
0
C-Reactive Protein
9007-41-4
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1978Informations de copyright
Copyright © 2020 Bock, Vogt, Mattecka, Yapici, Brunner, Fimpel, Unger and Sheriff.
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