The chemistry and applications of RNA 2'-OH acylation.
Journal
Nature reviews. Chemistry
ISSN: 2397-3358
Titre abrégé: Nat Rev Chem
Pays: England
ID NLM: 101703631
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
entrez:
28
9
2020
pubmed:
29
9
2020
medline:
29
9
2020
Statut:
ppublish
Résumé
RNA is a versatile biomolecule with a broad range of biological functions that go far beyond its initially described role as a simple information carrier. The development of chemical methods to control, manipulate and modify RNA has the potential to yield new insights into its many functions and properties. Traditionally, most of these methods involved the chemical modification of RNA structure using solid-state synthesis or enzymatic transformations. However, over the past 15 years, the direct functionalization of RNA by selective acylation of the 2'-hydroxyl (2'-OH) group has emerged as a powerful alternative that enables the simple modification of both synthetic and transcribed RNAs. In this Review, we discuss the chemical properties and design of effective reagents for RNA 2'-OH acylation, highlighting the unique problem of 2'-OH reactivity in the presence of water. We elaborate on how RNA 2'-OH acylation is being exploited to develop selective chemical probes that enable interrogation of RNA structure and function, and describe new developments and applications in the field.
Identifiants
pubmed: 32984545
doi: 10.1038/s41570-019-0147-6
pmc: PMC7513686
mid: NIHMS1557920
doi:
Types de publication
Journal Article
Langues
eng
Pagination
22-37Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM127295
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM130704
Pays : United States
Déclaration de conflit d'intérêts
Competing interests The authors declare no competing interests.
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