Testicular hormones mediate robust sex differences in impulsive choice in rats.
decision making
delay discounting
impulsivity
intertemporal choice
neuroscience
rat
sex differences
sex hormones
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
28 09 2020
28 09 2020
Historique:
received:
05
05
2020
accepted:
09
09
2020
entrez:
28
9
2020
pubmed:
29
9
2020
medline:
18
3
2021
Statut:
epublish
Résumé
Impairments in choosing optimally between immediate and delayed rewards are associated with numerous psychiatric disorders. Such 'intertemporal' choice is influenced by genetic and experiential factors; however, the contributions of biological sex are understudied and data to date are largely inconclusive. Rats were used to determine how sex and gonadal hormones influence choices between small, immediate and large, delayed rewards. Females showed markedly greater preference than males for small, immediate over large, delayed rewards (greater impulsive choice). This difference was neither due to differences in food motivation or reward magnitude perception, nor was it affected by estrous cycle. Ovariectomies did not affect choice in females, whereas orchiectomies increased impulsive choice in males. These data show that male rats exhibit less impulsive choice than females and that this difference is at least partly maintained by testicular hormones. These differences in impulsive choice could be linked to gender differences across multiple neuropsychiatric conditions.
Identifiants
pubmed: 32985975
doi: 10.7554/eLife.58604
pii: 58604
pmc: PMC7521924
doi:
pii:
Substances chimiques
Testicular Hormones
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : RF1 AG060778
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD071866
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG029421
Pays : United States
Organisme : NIDA NIH HHS
ID : K99 DA041493
Pays : United States
Informations de copyright
© 2020, Hernandez et al.
Déclaration de conflit d'intérêts
CH, CO, AW, TT, SB, CL, NW, BS, JB No competing interests declared
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