LTA, LEP, and TNF-a Gene Polymorphisms are Associated with Susceptibility and Overall Survival of Diffuse Large B-Cell lymphoma in an Arab Population: A Case-Control Study.
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ genetics
Case-Control Studies
Child
Female
Follow-Up Studies
Genetic Predisposition to Disease
Humans
Leptin
/ genetics
Lymphoma, Large B-Cell, Diffuse
/ genetics
Lymphotoxin-alpha
/ genetics
Male
Middle Aged
Polymorphism, Single Nucleotide
Prognosis
Survival Rate
Tumor Necrosis Factor-alpha
/ genetics
Young Adult
Arab population
Diffuse large B-cell lymphoma
Single nucleotide polymorphism
Journal
Asian Pacific journal of cancer prevention : APJCP
ISSN: 2476-762X
Titre abrégé: Asian Pac J Cancer Prev
Pays: Thailand
ID NLM: 101130625
Informations de publication
Date de publication:
01 Sep 2020
01 Sep 2020
Historique:
received:
25
04
2020
entrez:
28
9
2020
pubmed:
29
9
2020
medline:
12
6
2021
Statut:
epublish
Résumé
In this study, we aimed to explore the relationship between five selected proinflammatory and immune-mediated genes (TNF rs1800629G>A, rs361525G>A, rs1799964T>C, LTA rs1800683G>A, rs909253A>G, TNFAIP8 rs1042541C>T, LEPR rs1327118G>C, and LEP rs2167270G>A) and the risk and overall survival of DLBCL patients within the Jordanian Arab population. One hundred twenty-five patients (125) diagnosed with DLBCL at the King Abdullah University Hospital (KAUH) between 2013 and 2018 and 238 healthy cancer-free control subjects with similar geographic and ethnic backgrounds to the patients were included in the study. Genomic DNA was extracted from the formalin-fixed paraffin-embedded tissues of the subjects and from peripheral blood samples of the controls. The Sequenom MassARRAY® sequencer system (iPLEX GOLD) was used. The analyses included assessments of population variability and survival. Our study showed significant differences in the distribution of the studied polymorphisms of DLBCL between the patients and controls for TNF rs1800629G>A, LTA rs909253 G>A and LEP rs2167270 G>A. TNF rs1800629G>A (p = 0.01), in which the G allele harbors a higher risk of DLBCL (GG and GA genotypes when compared with AA genotype) (p = 0.044). The LTA rs909253 A>G polymorphism is associated with a higher risk of DLBCL in the allelic model (p = .004). LEP rs2167270 G>A polymorphism is associated with a decreased risk of DLBCL in the recessive mode models (p = .03). Subjects with the dominant model for TNF-a rs1799964 (TT genotype in comparison with the combined TT/TC genotype) and patients with the homozygous genotype (GG) of rs361525 have better overall survival rates. Our results confirmed the diversity and the heterogeneity of the disease. Although the study has a limitation because of its relatively small size, it clearly emphasizes the significance of ancestry and genetic composition as the determinants of DLBCL risk and behavior.<br />.
Identifiants
pubmed: 32986381
doi: 10.31557/APJCP.2020.21.9.2783
pmc: PMC7779465
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
LEP protein, human
0
LTA protein, human
0
Leptin
0
Lymphotoxin-alpha
0
TNF protein, human
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2783-2791Références
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