Imaginal disc growth factor maintains cuticle structure and controls melanization in the spot pattern formation of Bombyx mori.
Journal
PLoS genetics
ISSN: 1553-7404
Titre abrégé: PLoS Genet
Pays: United States
ID NLM: 101239074
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
28
02
2020
accepted:
06
07
2020
revised:
08
10
2020
pubmed:
29
9
2020
medline:
15
12
2020
entrez:
28
9
2020
Statut:
epublish
Résumé
The complex stripes and patterns of insects play key roles in behavior and ecology. However, the fine-scale regulation mechanisms underlying pigment formation and morphological divergence remain largely unelucidated. Here we demonstrated that imaginal disc growth factor (IDGF) maintains cuticle structure and controls melanization in spot pattern formation of Bombyx mori. Moreover, our knockout experiments showed that IDGF is suggested to impact the expression levels of the ecdysone inducible transcription factor E75A and pleiotropic factors apt-like and Toll8/spz3, to further control the melanin metabolism. Furthermore, the untargeted metabolomics analyses revealed that BmIDGF significantly affected critical metabolites involved in phenylalanine, beta-alanine, purine, and tyrosine metabolism pathways. Our findings highlighted not only the universal function of IDGF to the maintenance of normal cuticle structure but also an underexplored space in the gene function affecting melanin formation. Therefore, this study furthers our understanding of insect pigment metabolism and melanin pattern polymorphisms.
Identifiants
pubmed: 32986708
doi: 10.1371/journal.pgen.1008980
pii: PGENETICS-D-20-00311
pmc: PMC7544146
doi:
Substances chimiques
Insect Proteins
0
Melanins
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1008980Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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