Elevated inflammatory proteins in cerebrospinal fluid from patients with painful knee osteoarthritis are associated with reduced symptom severity.
Cerebrospinal fluid
Chemokines
Cytokines
Knee pain
Neuroinflammation
Osteoarthritis (OA)
Proximity extension assay (PEA)
Serum
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 12 2020
15 12 2020
Historique:
received:
28
01
2020
revised:
08
09
2020
accepted:
08
09
2020
pubmed:
29
9
2020
medline:
17
12
2020
entrez:
28
9
2020
Statut:
ppublish
Résumé
Neuroinflammation and periphery-to-CNS neuroimmune cross-talk in patients with painful knee osteoarthritis (OA) are poorly understood. We utilized proximity extension assay to measure the level of 91 inflammatory proteins in CSF and serum from OA patients and controls. The patients had elevated levels of 48 proteins in CSF indicating neuroinflammation. Ten proteins were correlated between CSF and serum and potentially involved in periphery-to-CNS neuroimmune cross-talk. Seven CSF proteins, all with previously reported neuroprotective effects, were associated with lower pain intensity and milder knee-related symptoms. Our findings indicate that neuroinflammation in OA could be protective and associated with less severe symptoms.
Identifiants
pubmed: 32987275
pii: S0165-5728(20)30056-4
doi: 10.1016/j.jneuroim.2020.577391
pii:
doi:
Substances chimiques
Biomarkers
0
Inflammation Mediators
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
577391Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.