Lysophosphatidylcholine Potentiates Antibacterial Activity of Polymyxin B.
antibiotic resistance
lysophosphatidylcholine
polymyxin B
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
17 11 2020
17 11 2020
Historique:
received:
25
06
2020
accepted:
20
09
2020
pubmed:
30
9
2020
medline:
18
5
2021
entrez:
29
9
2020
Statut:
epublish
Résumé
Polymyxin B, used to treat infections caused by antibiotic-resistant Gram-negative bacteria, produces nephrotoxicity at its current dosage. We show that a combination of nonbactericidal concentration of this drug and lysophosphatidylcholine (LPC) potently inhibits growth of
Identifiants
pubmed: 32988824
pii: AAC.01337-20
doi: 10.1128/AAC.01337-20
pmc: PMC7674032
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Lysophosphatidylcholines
0
Polymyxin B
J2VZ07J96K
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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