Evaluation of Trends and Prognosis Over Time in Patients with AML Relapsing After Allogeneic Hematopoietic Cell Transplant Reveals Improved Survival for Young Patients in Recent Years.
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Female
Follow-Up Studies
Hematopoietic Stem Cell Transplantation
/ mortality
Humans
Leukemia, Myeloid, Acute
/ mortality
Male
Middle Aged
Mortality
/ trends
Neoplasm Recurrence, Local
/ mortality
Prognosis
Remission Induction
Retrospective Studies
Salvage Therapy
Survival Rate
Transplantation, Homologous
Young Adult
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 12 2020
15 12 2020
Historique:
received:
18
08
2020
revised:
10
09
2020
accepted:
22
09
2020
pubmed:
30
9
2020
medline:
15
12
2021
entrez:
29
9
2020
Statut:
ppublish
Résumé
Relapsed acute myeloid leukemia (AML) post allogeneic hematopoietic cell transplantation (allo-HCT) has a dismal prognosis. To assess prognosis of patients with recurrent AML post allo-HCT over time, we analyzed European Society for Blood and Marrow Transplantation registry data of 8,162 adult patients with AML who relapsed between 2000 and 2018 after allo-HCT performed in first complete remission from matched sibling, unrelated, or haploidentical donors. The 2-year overall survival (OS) rate from relapse was 17%. For 3,630 patients, <50 years of age, the 2-year OS continuously increased from 16% between 2000 and 2004 to 18% for 2005-2009, to 21% for 2010-2014, and to 26% for 2015-2018 ( Outcome after posttransplant relapse among younger patients has improved significantly in recent years, likely reflecting, among other factors, the efficacy of posttransplant salvage including second allo-HCT.
Identifiants
pubmed: 32988970
pii: 1078-0432.CCR-20-3134
doi: 10.1158/1078-0432.CCR-20-3134
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
6475-6482Informations de copyright
©2020 American Association for Cancer Research.
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