Magnesium Citrate Increases Pain Threshold and Reduces TLR4 Concentration in the Brain.
Brain
Magnesium citrate
Muscle
Pain perception
Sciatic nerve
Toll-like receptor 4
Journal
Biological trace element research
ISSN: 1559-0720
Titre abrégé: Biol Trace Elem Res
Pays: United States
ID NLM: 7911509
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
25
04
2020
accepted:
09
09
2020
pubmed:
30
9
2020
medline:
22
6
2021
entrez:
29
9
2020
Statut:
ppublish
Résumé
Magnesium is being investigated in various clinical conditions and has shown to be effective in some chronic pain models. However, it is not clear if oral magnesium use affects pain perception in acute pain. TLR4's (toll-like receptor) role in pain perception has emerged through its role in immune pathways and ion channels. The aim of this study is to investigate the effect of a single oral dose of magnesium citrate on pain conduction and whether with magnesium, the expression of TLR4 changes in the acute phase. Following a single dose of 66-mg/kg magnesium citrate administration to male Balb-c mice, pain perception (via hot-plate test), motor conduction (via electrophysiological recording, forelimb grip strength, rotarod and open-field tests), and emotional state (via elevated plus maze and forced swim test) were evaluated. In behavioral experiments, the control group was compared with applied magnesium for three different time groups (4, 8, 24 h). TLR4 expression was measured in four groups: control, magnesium (Mg), hot plate (HP), and Mg + HP. Hot plate latency was prolonged in the magnesium group (p < 0.0001) and electrophysiological recordings (p < 0.001) and forelimb grip strength measurement (p < 0.001) determined motor latency. Compared with the untreated hot plate group, TLR4 levels was lower in the brain (p = 0.023) and higher in the sciatic nerve (p = 0.001) in the magnesium-treated hot plate group. Consequently, the study indicated a single dose of magnesium citrate appeared to cause weakening in the transmission and perception of nociceptive pain. TLR4 may act as a regulator in magnesium's effects on pain perception.
Identifiants
pubmed: 32989649
doi: 10.1007/s12011-020-02384-5
pii: 10.1007/s12011-020-02384-5
doi:
Substances chimiques
Organometallic Compounds
0
Tlr4 protein, mouse
0
Toll-Like Receptor 4
0
Citric Acid
2968PHW8QP
magnesium citrate
RHO26O1T9V
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1954-1966Références
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