The impact of preoperative MRI-based apparent diffusion coefficients on local recurrence and outcome in patients with cerebral metastases.
ADC values
Cerebral metastases
MRI
imaging
overall survival
predictors
progression free survival recurrence
Journal
British journal of neurosurgery
ISSN: 1360-046X
Titre abrégé: Br J Neurosurg
Pays: England
ID NLM: 8800054
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
pubmed:
30
9
2020
medline:
22
2
2023
entrez:
29
9
2020
Statut:
ppublish
Résumé
Surgery of single cerebral metastases is standard but frequently fails to achieve local tumour control. Reliable predictors for local tumour progression and overall survival are unknown. MRI-based apparent diffusion coefficients (ADC) correlate with tumour cellularity and invasion. The present study analysed a potential relation between the MRI based apparent diffusion coefficients local recurrence and outcome in patients with brain metastases. A retrospective analysis was performed for patients with cerebral metastases and complete surgical resection evaluated by an early postoperative MRI < 72h. Minimal ADC and mean ADC were assessed in preoperative 1,5T-MRI scans by placing regions of interests in the tumour and the peritumoural tissue. Analysis of the relation between ADC values, local progression and outcome was performed in 86 patients with a mean age of 59 years (range 33-83 years). Primary site was NSCLC in 37.2% of all cases. Despite complete resection 33.7% of all patients suffered from local in-brain-progression. There were no significant differences in ADC values in groups based on histology. In the present cohort, the mean ADCmin and the mean ADCmean within the metastasis did not differ significantly between patients with and without a later local in-brain progression (634 × 10 In the present study analysed ADC values had no significant impact on local in brain progression and survival parameters.
Sections du résumé
BACKGROUND
UNASSIGNED
Surgery of single cerebral metastases is standard but frequently fails to achieve local tumour control. Reliable predictors for local tumour progression and overall survival are unknown. MRI-based apparent diffusion coefficients (ADC) correlate with tumour cellularity and invasion. The present study analysed a potential relation between the MRI based apparent diffusion coefficients local recurrence and outcome in patients with brain metastases.
METHODS
UNASSIGNED
A retrospective analysis was performed for patients with cerebral metastases and complete surgical resection evaluated by an early postoperative MRI < 72h. Minimal ADC and mean ADC were assessed in preoperative 1,5T-MRI scans by placing regions of interests in the tumour and the peritumoural tissue.
RESULTS
UNASSIGNED
Analysis of the relation between ADC values, local progression and outcome was performed in 86 patients with a mean age of 59 years (range 33-83 years). Primary site was NSCLC in 37.2% of all cases. Despite complete resection 33.7% of all patients suffered from local in-brain-progression. There were no significant differences in ADC values in groups based on histology. In the present cohort, the mean ADCmin and the mean ADCmean within the metastasis did not differ significantly between patients with and without a later local in-brain progression (634 × 10
CONCLUSION
UNASSIGNED
In the present study analysed ADC values had no significant impact on local in brain progression and survival parameters.
Identifiants
pubmed: 32990044
doi: 10.1080/02688697.2020.1817856
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM